Simulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca2+ release mechanism

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 294, Issue 5, 2008, Pages

  Colleran, Patrick N ^a   Behnke, Bradley J ^a,b   Wilkerson, M Keith ^a   Donato, Anthony J ^a   Delp, Michael D ^a,c  

^a TEXAS A AND M UNIVERSITY   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

Hindlimb unloading; Vasoconstrictor responsiveness

Indexed keywords

CALCIUM ION; MESSENGER RNA; RYANODINE RECEPTOR 2; RYANODINE RECEPTOR 3; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2; UNCLASSIFIED DRUG; CAFFEINE; CENTRAL STIMULANT AGENT; NORADRENALIN; POTASSIUM CHLORIDE; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DYNAMICS; MALE; MESENTERIC ARTERY; MESENTERY BLOOD FLOW; MICROGRAVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESISTANCE BLOOD VESSEL; VASOCONSTRICTION; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; CALCIUM SIGNALING; CAPILLARY; DRUG EFFECT; GENETICS; HISTOLOGY; IMMOBILIZATION; PHYSIOLOGY; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT; WEIGHTLESSNESS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; CAFFEINE; CALCIUM SIGNALING; CAPILLARIES; CENTRAL NERVOUS SYSTEM STIMULANTS; HINDLIMB SUSPENSION; MALE; MESENTERIC ARTERIES; MUSCLE, SKELETAL; NOREPINEPHRINE; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; WEIGHTLESSNESS SIMULATION;

EID: 45549097330     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00084.2008     Document Type: Article

References (59)

1. Arbeille P, Achaibou F, Fomina G, Pottier JM, Porcher M. Regional blood flow in microgravity: adaptation and deconditioning. Med Sci Sports Exerc 28: S70-S79, 1996.
2. Arbeille P, Fomina G, Archaibou J, Potter JM, Kotovskaya A. Cardiac and vascular adaptation to 0g with and withouth thigh cuffs (Antares 14 and Altair 21 day Mir spaceflights). Acta Astronautica 36: 6-10, 1996.
3. Armstrong RB, Delp MD, Goljan EF, Laughlin MH. Distribution of blood flow in muscles of miniature swine during exercise. J Appl Physiol 62: 1285-1298, 1987.
4. Behnke BJ, Kindig CA, Musch TI, Koga S, Poole DC. Dynamics of microvascular oxygen pressure across the rest-exercise transition in rat skeletal muscle. Respir Physiol 126: 53-63, 2001.
5. Behnke BJ, Zawieja DC, Gashev AA, Ray CA, Delp MD. Diminished mesenteric vaso- and venoconstriction and elevated plasma ANP and BNP with simulated microgravity. J Appl Physiol (January 24, 2008).
6. Blomqvist CG, Stone HL. Cardiovascular adjustments to gravitational stress. In Handbook of Physiology The Cardiovascular System pp. 1027-1063. American Physiological Society, Bethesda, MD, 1983.
7. Boittin FX, Macrez N, Halet G, Mironneau J. Norepinephrine-induced Ca(2+) waves depend on InsP(3) and ryanodine receptor activation in vascular myocytes. Am J Physiol Cell Physiol 277: C139-C151, 1999.
8. Buckey JC Jr, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE, Gaffney FA, Blomqvist CG. Orthostatic intolerance after spaceflight. J Appl Physiol 81: 7-18, 1996.
9. Callera GE, Bendhack LM. Contribution of sarcoplasmic reticulum calcium uptake and L-type calcium channels to altered vascular responsiveness in the aorta of renal hypertensive rats. Gen Pharmacol 33: 457-466, 1999.
10. Coussin F, Macrez N, Morel JL, Mironneau J. Requirement of ryanodine receptor subtypes 1 and 2 for Ca(2+)-induced Ca(2+) release in vascular myocytes. J Biol Chem 275: 9596-9603, 2000.
11. Davis MJ, Donovitz JA, Hood JD. Stretch-activated single-channel and whole cell currents in vascular smooth muscle cells. Am J Physiol Cell Physiol 262: C1083-C1088, 1992.
12. Davis MJ, Hill MA. Signaling mechanisms underlying the vascular myogenic response. Physiol Rev 79: 387-423, 1999.
13. Delp MD. Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloading. J Appl Physiol 86: 1178-1184, 1999.
14. Delp MD, Brown M, Laughlin MH, Hasser EM. Rat aortic vasoreactivity is altered by old age and hindlimb unloading. J Appl Physiol 78: 2079-2086, 1995.
15. Delp MD, Colleran PN, Wilkerson MK, McCurdy MR, Muller-Delp J. Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravity. Am J Physiol Heart Circ Physiol 278: H1866-H1873, 2000.
16. Delp MD, Holder-Binkley T, Laughlin MH, Hasser EM. Vasoconstrictor properties of rat aorta are diminished by hindlimb unweighting. J Appl Physiol 75: 2620-2628, 1993.
17. Desplanches D, Mayet MH, Sempore B, Frutoso J, Flandrois R. Effect of spontaneous recovery or retraining after hindlimb suspension on aerobic capacity. J Appl Physiol 63: 1739-1743, 1987.
18. Donato AJ, Lesniewski LA, Delp MD. The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles. Cardiovasc Res 66: 393-401, 2005.
19. Duling BR, Gore RW, Dacey RG Jr, Damon DN. Methods for isolation, cannulation, and in vitro study of single microvessels. Am J Physiol Heart Circ Physiol 241: H108-H116, 1981.
20. Dunbar SL, Berkowitz DE, Brooks-Asplund EM, Shoukas AA. The effects of hindlimb unweighting on the capacitance of rat small mesenteric veins. J Appl Physiol 89: 2073-2077, 2000.
21. Fenger-Gron J, Mulvany MJ, Christensen KL. Mesenteric blood pressure profile of conscious, freely moving rats. J Physiol 488: 753-760, 1995.
22. Hatton DC, Yue Q, Chapman J, Xue H, Dierickx J, Roullet C, Coste S, Roullet JB, McCarron DA. Blood pressure and mesenteric resistance arterial function after spaceflight. J Appl Physiol 92: 13-17, 2002.
23. Hwang S, Shelkovnikov S, Purdy RE. Simulated microgravity effects on the rat carotid and femoral arteries: role of contractile protein expression and mechanical properties of the vessel wall. J Appl Physiol 102: 1595-1603, 2007.
24. Jaggar JH, Porter VA, Lederer WJ, Nelson MT. Calcium sparks in smooth muscle. Am J Physiol Cell Physiol 278: C235-C256, 2000.
25. 2+ uncaging in smooth muscle. J Gen Physiol 127: 225-235, 2006.
26. + channels. J Physiol 508: 211-221, 1998.
27. Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Diedrich A, Biaggioni I, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC, Cooke WH, Baisch FJ, Robertson D, Eckberg DL, Blomqvist CG. Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight. J Physiol 538: 331-340, 2002.
28. Looft-Wilson RC, Gisolfi CV. Rat small mesenteric artery function after hindlimb suspension. J Appl Physiol 88: 1199-1206, 2000.
29. Martel E, Champeroux P, Lacolley P, Richard S, Safar M, Cuche JL. Central hypervolemia in the conscious rat: a model of cardiovascular deconditioning. J Appl Physiol 80: 1390-1396, 1996.
30. Maurel D, Ixart G, Barbanel G, Mekaouche M, Assenmacher I. Effects of acute tilt from orthostatic to head-down antiorthostatic restraint and of sustained restraint on the intra-cerebroventricular pressure in rats. Brain Res 736: 165-173, 1996.
31. McDonald KS, Delp MD, Fitts RH. Effect of hindlimb unweighting on tissue blood flow in the rat. J Appl Physiol 72: 2210-2218, 1992.
32. Meininger GA, Davis MJ. Cellular mechanisms involved in the vascular myogenic response. Am J Physiol Heart Circ Physiol 263: H647-H659, 1992.
33. 2+ transients in smooth muscle of pressurized rat resistance arteries during myogenic and agonist stimulation. J Physiol 518: 815-824, 1999.
34. 2+ concentration in rat portal vein myocytes. Am J Physiol Heart Circ Physiol 273: H2867-H2875, 1997.
35. Muller-Delp JM, Spier SA, Ramsey MW, Lesniewski LA, Papadopoulos A, Humphrey JD, Delp MD. Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles. Am J Physiol Heart Circ Physiol 282: H1843-H1854, 2002.
36. Mulvagh SL, Charles JB, Riddle JM, Rehbein TL, Bungo MW. Echocardiographic evaluation of the cardiovascular effects of short-duration spaceflight. J Clin Pharmacol 31: 1024-1026, 1991.
37. Nakayama K, Suzuki S, Sugi H. Physiological and ultrastructural studies on the mechanism of stretch-induced contractile activation in rabbit cerebral artery smooth muscle. Jpn J Physiol 36: 745-760, 1986.
38. Overton JM, Tipton CM. Effect of hindlimb suspension on cardiovascular responses to sympathomimetics and lower body negative pressure. J Appl Physiol 68: 355-362, 1990.
39. 2 max and regional blood flow responses to exercise. J Appl Physiol 66: 653-659, 1989.
40. Papadopoulos A, Delp MD. Effects of hindlimb unweighting on the mechanical and structure properties of the rat abdominal aorta. J Appl Physiol 94: 439-445, 2003.
41. Purdy RE, Duckles SP, Krause DN, Rubera KM, Sara D. Effect of simulated microgravity on vascular contractility. J Appl Physiol 85: 1307-1315, 1998.
42. Rowell LB. Human Cardiovascular Control. New York: Oxford University Press, 1993.
43. Sangha DS, Vaziri ND, Ding Y, Purdy RE. Vascular hyporesponsiveness in simulated microgravity: role of nitric oxide-dependent mechanisms. J Appl Physiol 88: 507-517, 2000.
44. Schmid M, McNally PG, Piemme TE, Shaver JA. Effects of bed rest on forearm vascular responses to tyramine and norepinephrine. In: Hypogravic and Hypodynamic Environments (2nd ed.), edited by Murray RH and McCally M. Washington, DC: NASA, 1971, p. 211-223.
45. Schulte LM, Navarro J, Kandarian SC. Regulation of sarcoplasmic reticulum calcium pump gene expression by hindlimb unweighting. Am J Physiol Cell Physiol 264: C1308-C1315, 1993.
46. Shoemaker JK, Hogeman CS, Silber DH, Gray K, Herr M, Sinoway LI. Head-down-tilt bed rest alters forearm vasodilator and vasoconstrictor responses. J Appl Physiol 84: 1756-1762, 1998.
47. Spier SA, Delp MD, Meininger CJ, Donato AJ, Ramsey MW, Muller-Delp JM. Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles. J Physiol (London) 556: 947-958, 2004.
48. Steenbergen JM, Fay FS. The quantal nature of calcium release to caffeine in single smooth muscle cells results from activation of the sarcoplasmic reticulum Ca(2+)-ATPase. J Biol Chem 271: 1821-1824, 1996.
49. Uchida E, Bohr DF. Myogenic tone in isolated perfused resistance vessels from rats. Am J Physiol 216: 1343-1350, 1969.
50. Watanabe J, Horiguchi S, Karibe A, Keitoku M, Takeuchi M, Satoh S, Takishima T, Shirato K. Effects of ryanodine on development of myogenic response in rat small skeletal muscle arteries. Cardiovasc Res 28: 480-484, 1994.
51. Watanabe J, Karibe A, Horiguchi S, Keitoku M, Satoh S, Takishima T, Shirato K. Modification of myogenic intrinsic tone and [Ca2+]i of rat isolated arterioles by ryanodine and cyclopiazonic acid. Circ Res 73: 465-472, 1993.
52. Watenpaugh DE, Hargens AR. The cardiovascular system in microgravity. In: Handbook of Physiology, Bethesda, MD: American Physiological Society, 1996, p. 631-674.
53. Waters WW, Ziegler MG, Meck JV. Postspaceflight orthostatic hypotension occurs mostly in women and is predicted by low vascular resistance. J Appl Physiol 92: 586-594, 2002.
54. Whitson PA, Charles JB, Williams WJ, Cintron NM. Changes in sympathoadrenal response to standing in humans after spaceflight. J Appl Physiol 79: 428-433, 1995.
55. Wilkerson MK, Lesniewski LA, Golding EM, Bryan RM, Amin A, Wilson E, Delp MD. Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through an endothelial nitric oxide mechanism. Am J Physiol Heart Circ Physiol 288: H1652-H1661, 2005.
56. Wilkerson MK, Muller-Delp J, Colleran PN, Delp MD. Effects of hindlimb unloading on rat cerebral, splenic, and mesenteric resistance artery morphology. J Appl Physiol 87: 2115-2121, 1999.
57. Woodman CR, Sebastian LA, Tipton CM. Influence of simulated microgravity on cardiac output and blood flow distribution during exercise. J Appl Physiol 79: 1762-1768, 1995.
58. Wronski TJ, Morey-Holton ER. Skeletal response to simulated weightlessness: a comparison of suspension techniques. Aviat Space Environ Med 58: 63-68, 1987.
59. Zhang LF, Mao QW, Ma J, Yu ZB. Effects of simulated weightlessness on arterial vasculature (an experimental study of vascular deconditioning). J Grav Physiol 3: 5-8, 1996.