Porphyromonas gingivalis lipopolysaccharide induces tumor necrosis factor-α and interleukin-6 secretion, and CCL25 gene expression, in mouse primary gingival cell lines: Interleukin-6-driven activation of CCL2

Journal of Periodontal Research

Volumn 43, Issue 4, 2008, Pages 431-439

  Ekhlassi, S ^a   Scruggs, L Y ^a   Garza, T ^a   Montufar Solis, D ^a   Moretti, A J ^a   Klein, J R ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Inflammation; Mucosa; Oral; Periodontium; Porphyromonas gingivalis

Indexed keywords

BETA CHEMOKINE; CCL2 PROTEIN, MOUSE; CCL25 PROTEIN, MOUSE; CYTOKINE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; C57BL MOUSE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM CELL; ESCHERICHIA COLI; FEMALE; FIBROBLAST; GINGIVA; HUMAN; HYBRIDOMA; IMMUNOLOGY; MOUSE; MOUSE STRAIN; PATHOLOGY; PORPHYROMONAS GINGIVALIS; SECRETION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CHEMOKINE CCL2; CHEMOKINES, CC; CYTOKINE RECEPTOR GP130; CYTOKINES; EPITHELIAL CELLS; ESCHERICHIA COLI; FEMALE; FIBROBLASTS; GINGIVA; HUMANS; HYBRIDOMAS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; PORPHYROMONAS GINGIVALIS; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 45549096261     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2008.01090.x     Document Type: Article

References (36)

1. Kent LW, Rahemtulla F, Michalek SM. Interleukin (IL)-1 and Porphyromonas gingivalis lipopolysaccharide stimulation of IL-6 production by fibroblasts derived from healthy or periodontally diseased human gingival tissue. J Periodontol 1999 70 : 274 282.
2. Wang PL, Ohura K. Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors. Crit Rev Oral Biol Med 2002 13 : 132 142.
3. Wang PL, Oido-Mori M, Fujii T et al. Heterogeneous expression of Toll-like receptor 4 and downregulation of Toll-like receptor 4 expression on human gingival fibroblasts by Porphyromonas gingivalis lipopolysaccharide. Biochem Biophys Res Commun 2001 288 : 863 867.
4. Muthukuru M, Jotwani R, Cutler CW. Oral mucosal endotoxin tolerance induction in chronic periodontitis. Infect Immun 2005 73 : 687 694.
5. Wang PL, Azuma Y, Shinohara M, Ohura K. Toll-like receptor 4-mediated signal pathway induced by Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts. Biochem Biophys Res Commun 2000 273 : 1161 1167.
6. Steffen MJ, Holt SC, Ebersole JL. Porphyromonas gingivalis induction of mediator and cytokine secretion by human gingival fibroblasts. Oral Microbiol Immunol 2000 15 : 172 180.
7. Andrian E, Grenier D, Rouabhia M. In vitro models of tissue penetration and destruction by Porphyromonas gingivalis. Infect Immun 2004 72 : 4689 4698.
8. Hosokawa Y, Hosokawa I, Ozaki K et al. CXCL12 and CXCR4 expression by human gingival fibroblasts in periodontal disease. Clin Exp Immunol 2005 141 : 467 474.
9. Wang PL, Shirasu S, Shinohar M et al. IL-10 inhibits Porphyromonas gingivalis LPS-stimulated human gingival fibroblasts production of IL-6. Biochem Biophys Res Commun 1999 263 : 372 377.
10. Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 1994 83 : 113 118.
11. Hurst SM, Wilkinson TS, McLoughlin RM et al. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 2001 14 : 705 714.
12. Schindler R, Mancilla J, Endres S, Ghorbani R, Clark SC, Dinarello CA. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 1990 75 : 40 47.
13. Jones SA. Directing transition from innate to acquired immunity: defining a role for IL-6. J Immunol 2005 175 : 3463 3468.
14. Kamimura D, Ishihara K, Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 2003 149 : 1 38.
15. Otten K, Dragoo J, Wang HC, Klein JR. Antigen-induced chemokine activation in mouse buccal epithelium. Biochem Biophys Res Commun 2003 304 : 36 40.
16. Kunkel EJ, Campbell DJ, Butcher EC. Chemokines in lymphocyte trafficking and intestinal immunity. Microcirculation 2003 10 : 313 323.
17. Kabelitz D, Wesch D. Features and functions of γδ T lymphocytes: focus on chemokines and their receptors. Crit Rev Immunol 2003 23 : 339 370.
18. Onai N, Kitabatake M, Zhang YY, Ishikawa H, Ishikawa S, Matsushima K. Pivotal role of CCL25 (TECK)-CCR9 in the formation of gut cryptopatches and consequent appearance of intestinal intraepithelial T lymphocytes. Int Immunol 2002 14 : 687 694.
19. Farr AG, Hosier S, Braddy SC et al. Medullary epithelial cell lines from murine thymus constitutively secrete IL-1 and hematopoietic growth factors and express class II antigens in response to recombinant interferon-gamma. Cell Immunol 1989 119 : 427 444.
20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔ Ct) Method. Methods 2001 25 : 402 408.
21. McGrory K, Flaitz CM, Klein JR. Chemokine changes during oral wound healing. Biochem Biophys Res Commun 2004 324 : 317 320.
22. Kallen KJ. The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases. Biochim Biophys Acta 2002 1592 : 323 343.
23. Nowell MA, Richards PJ, Horiuchi S et al. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J Immunol 2003 171 : 3202 3209.
24. Gaillard JP, Mani JC, Liautard J, Klein B, Brochier J. Interleukin-6 receptor signaling. I. gp80 and gp130 receptor interaction in the absence of interleukin-6. Eur Cytokine Netw 1999 10 : 43 48.
25. Wurbel MA, Philippe JM, Nguyen C et al. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur J Immunol 2000 30 : 262 271.
26. Kunkel EJ, Campbell JJ, Haraldsen G et al. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J Exp Med 2000 192 : 761 768.
27. Zabel BA, Agace WW, Campbell JJ et al. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. J Exp Med 1999 190 : 1241 1256.
28. Jameson J, Ugarte K, Chen N et al. A role for skin γδ T cells in wound repair. Science 2002 296 : 747 749.
29. Boismenu R, Havran WL. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 1994 266 : 1253 1255.
30. Boismenu R, Feng L, Xia YY, Chang JC, Havran WL. Chemokine expression by intraepithelial γδ T cells. Implications for the recruitment of inflammatory cells to damaged epithelia. J Immunol 1996 157 : 985 992.
31. Pepin LF, Roger T, Morisset J, Seman M. Preferential Vδ1 expression among TcR γ/δ-bearing T cells in human oral epithelium. Scand J Immunol 1993 37 : 289 294.
32. Lundqvist C, Baranov V, Teglund S, Hammarstrom S, Hammarstrom ML. Cytokine profile and ultrastructure of intraepithelial γδ T cells in chronically inflamed human gingiva suggest a cytotoxic effector function. J Immunol 1994 153 : 2302 2312.
33. Otten K, Wang HC, Wyde PR, Klein JR. Modulation of γδ T cells in mouse buccal epithelium following antigen priming. Biochem Biophys Res Commun 2002 294 : 626 629.
34. Lundqvist C, Hammarstrom ML. T-cell receptor γδ-expressing intraepithelial lymphocytes are present in normal and chronically inflamed human gingiva. Immunology 1993 79 : 38 45.
35. Kawahara K, Fukunaga M, Takata T, Kawamura M, Morishita M, Iwamoto Y. Immunohistochemical study of gamma delta T cells in human gingival tissues. J Periodontol 1995 66 : 775 779.
36. Havran WL, Grell S, Duwe G et al. Limited diversity of T-cell receptor gamma-chain expression of murine Thy-1+ dendritic epidermal cells revealed by Vγ 3-specific monoclonal antibody. Proc Natl Acad Sci U S A 1989 86 : 4185 4189.