Pivotal role of CCL25 (TECK)-CCR9 in the formation of gut cryptopatches and consequent appearance of intestinal intraepithelial T lymphocytes

International Immunology

Volumn 14, Issue 7, 2002, Pages 687-694

  Onai, Nobuyuki ^a   Kitabatake, Masahiro ^b   Zhang, Yan Yun ^a   Ishikawa, Hiromichi ^c   Ishikawa, Sho ^a   Matsushima, Kouji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

CCL25; CCR9; Cryptopatches; Intracellular chemokine; Intraepithelial T lymphocytes

Indexed keywords

BETA CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR9; GLYCOPROTEIN P 15095; MESSENGER RNA; UNCLASSIFIED DRUG; ALPHA CHEMOKINE; CCL25 PROTEIN, MOUSE; GPR 9 6 RECEPTOR; GPR-9-6 RECEPTOR; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL COUNT; CHEMOTAXIS; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION; INTESTINE CRYPT; INTESTINE EPITHELIUM CELL; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE; SPLEEN CELL; STEM CELL; STROMA CELL; T LYMPHOCYTE; THYMOCYTE; ANIMAL; BONE MARROW; C57BL MOUSE; COMPARATIVE STUDY; GENETIC TRANSFORMATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNE SYSTEM; IMMUNOLOGY; INTESTINE MUCOSA; NEUTROPHIL CHEMOTAXIS; PHYSIOLOGY;

ANIMALS; BONE MARROW; CHEMOKINES, CC; CHEMOKINES, CXC; CHEMOTAXIS, LEUKOCYTE; IMMUNE SYSTEM; INTESTINAL MUCOSA; INTESTINE, SMALL; MICE; MICE, INBRED C57BL; RECEPTORS, CHEMOKINE; T-LYMPHOCYTES; TRANSFORMATION, GENETIC;

EID: 0036312122     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxf035     Document Type: Article

References (30)

1. Overview of the mucosal immune system
2. + lympho-hemopoietic progenitors develop
3. The anatomical basis of intestinal immunity
4. Thymus independent T cell development and selection in the intestinal epithelium
5. Extrathymic T cell differentiation
6. An opposite pattern of selection of a single T cell antigen receptor in the thymus and among intraepithelial lymphocytes
7. Generation of intestinal T cells from progenitors residing in gut cryptopatches
8. Gut cryptopatches: Direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis
9. Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells
10. TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development
11. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an regional immunity
12. Cutting edge: Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK
13. TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor
14. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9
15. Chemokines define distinct microenvironments in the developing thymus
16. Expression of CCR9 beta-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8(+) T cells from secondary lymphoid organs
17. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis
18. Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy
19. Phenotypic knockout of HIV type 1 chemokine coreceptor CCR-5 by intrakines as potential therapeutic approach for HIV-1 infection
20. Impairment of lymphopoiesis and myelopoiesis in mice reconstituted with bone marrow-hematopoietic progenitor cells expressing SDF-1-intrakine
21. Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes
22. Three distinctive steps in Peyer's patch formation of murine embryo
23. Essential role of IL-7 receptor α in the formation of Peyer's patch anlage
24. + CD3-cells in the embryonic intestine induces the organizing center of Peyer's patches
25. Development of intestinal intraepithelial T lymphocytes is independent of Peyer's patches and lymph nodes in aly mutant mice
26. Development and maturation of secondary lymphoid tissues
27. Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis
28. A chemokine-driven positive feedback loop organizes lymphoid follicles
29. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
30. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs