Kidney Function and Risk Factors for Left Ventricular Hypertrophy in Untreated Uncomplicated Essential Hypertension

American Journal of Kidney Diseases

Volumn 52, Issue 1, 2008, Pages 74-84

  Perticone, Francesco ^a   Maio, Raffaele ^a   Ruberto, Carmen ^a   Cassano, Susanna ^a   Tripepi, Giovanni ^b   Perticone, Maria ^a   Sesti, Giorgio ^a   Zoccali, Carmine ^b  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b CNR   (Italy)

Author keywords

Acetylcholine; C reactive protein; creatinine; decreased kidney function; endothelial dysfunction; Homeostatic Model Assessment for insulin resistance (HOMA R) index; left ventricular hypertrophy

Indexed keywords

ACETYLCHOLINE; C REACTIVE PROTEIN; CREATININE; URIC ACID;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CAUSAL ATTRIBUTION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; ESSENTIAL HYPERTENSION; FEMALE; FOREARM BLOOD FLOW; GLOMERULUS FILTRATION RATE; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; KIDNEY FUNCTION; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; STATISTICAL SIGNIFICANCE; URIC ACID BLOOD LEVEL;

ADULT; AGE DISTRIBUTION; BLOOD PRESSURE DETERMINATION; C-REACTIVE PROTEIN; CHOLESTEROL, LDL; COMORBIDITY; CREATININE; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; INCIDENCE; ITALY; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROBABILITY; PROGNOSIS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; SURVIVAL RATE;

EID: 45449105363     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2008.02.302     Document Type: Article

References (46)

1. Devereux R.B., Okin P.M., and Roman M.J. Left ventricular hypertrophy as a surrogate end-point in hypertension. Clin Exp Hypertens 21 (1999) 583-593
2. Levy D., Garrison R.J., Savage D.D., Kannel W.B., and Castelli W.P. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 322 (1990) 1561-1566
3. Muiesan M.L., Salvetti M., Rizzoni D., Monteduro C., Castellano M., and Agabiti-Rosei E. Persistence of left ventricular hypertrophy is a stronger indicator of cardiovascular events than baseline left ventricular mass or systolic performance: 10 Years of follow-up. J Hypertens Suppl 14 (1996) S43-S49
4. Verdecchia P., Angeli F., Pittavini L., Gattobigio R., Benemio G., and Porcellati C. Regression of left ventricular hypertrophy and cardiovascular risk changes in hypertensive patients. Ital Heart J 5 (2004) 505-510
5. Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). 2007 Guidelines for the management of arterial hypertension. J Hypertens 25 (2007) 1105-1187
6. Schillaci G., Reboldi G., and Verdecchia P. High-normal serum creatinine concentration is a predictor of cardiovascular risk in essential hypertension. Arch Intern Med 161 (2001) 886-891
7. Fesler P., Du Cailar G., Ribstein J., and Mimran A. Left ventricular remodeling and renal function in never-treated essential hypertension. J Am Soc Nephrol 14 (2003) 881-887
8. Schmieder R.E., Messerli F.H., Garavaglia G., and Nunez B. Glomerular hyperfiltration indicates early target organ damage in essential hypertension. JAMA 264 (1990) 2775-2780
9. Perticone F., Maio R., Ceravolo R., Cosco C., Cloro C., and Mattioli P.L. Relationship between left ventricular mass and endothelium-dependent vasodilation in never-treated hypertensive patients. Circulation 99 (1999) 1991-1996
10. Lind L., Andersson P.E., Andren B., Hanni A., and Lithell H.O. Left ventricular hypertrophy in hypertension is associated with the insulin resistance metabolic syndrome. J Hypertens 13 (1995) 433-438
11. Pedrinelli R., Dell'Omo G., Di Bello V., et al. Low-grade inflammation and microalbuminuria in hypertension. Arterioscler Thromb Vasc Biol 24 (2004) 2414-2419
12. Viazzi F., Parodi D., Leoncini G., et al. Serum uric acid and target organ damage in primary hypertension. Hypertension 45 (2005) 991-996
13. Levey A.S., Bosch J.P., Lewis J.B., Greene T., Rogers N., and Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130 (1999) 461-470
14. Bonora E., Kiechl S., Willeit J., et al. Prevalence of insulin resistance in metabolic disorders: The Bruneck Study. Diabetes 47 (1998) 1643-1649
15. de Simone G., Devereux R.B., Daniels S.R., Koren M.J., Meyer R.A., and Laragh J.H. Effect of growth on variability of left ventricular mass: Assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk. J Am Coll Cardiol 25 (1995) 1056-1062
16. Panza J.A., Quyyumi A.A., Brush Jr. J.E., and Epstein S.E. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 323 (1990) 22-27
17. Altman D.G. Practical Statistics for Medical Research (1998), Chapman & Hall, London, UK 349-351
18. Levin A., Ethier J., Carlisle E.J., et al. Left ventricular mass index increase in early renal disease: Impact of decline in hemoglobin. Am J Kidney Dis 34 (1999) 125-134
19. Zoccali C., Benedetto F.A., Mallamaci F., et al. Prognostic impact of the indexation of left ventricular mass in patients undergoing dialysis. J Am Soc Nephrol 12 (2001) 2768-2774
20. Astor B.C., Arnett D.K., Brown A., and Coresh J. Association of kidney function and hemoglobin with left ventricular morphology among African Americans: The Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis 43 (2004) 836-845
21. Henry R.M., Kamp O., Kostense P.J., et al. Mild renal insufficiency is associated with increased left ventricular mass in men, but not in women: An arterial stiffness-related phenomenon-The Hoorn Study. Kidney Int 68 (2005) 673-679
22. Smilde T.D., Asselbergs F.W., Hillege H.L., et al. Mild renal dysfunction is associated with electrocardiographic left ventricular hypertrophy. Am J Hypertens 18 (2005) 342-347
23. Palmieri V., Okin P.M., de Simone G., et al. Electrocardiographic characteristics and metabolic risk factors associated with inappropriately high left ventricular mass in patients with electrocardiographic left ventricular hypertrophy: The LIFE Study. J Hypertens 25 (2007) 1079-1085
24. Devereux R.B. Hypertensive cardiac hypertrophy: Pathophysiologic and clinical characteristics. In: Laragh J.H.B.B. (Ed). Hypertension: Pathophysiology, Diagnosis and Management. (ed 2) (1995), Raven, New York, NY 409-424
25. Vasan R.S., Larson M.G., Levy D., Evans J.C., and Benjamin E.J. Distribution and categorization of echocardiographic measurements in relation to reference limits: The Framingham Heart Study: Formulation of a height- and sex-specific classification and its prospective validation. Circulation 96 (1997) 1863-1873
26. Schmieder R.E., Messerli F.H., Ruddel H., et al. Sodium intake modulates left ventricular hypertrophy in essential hypertension. J Hypertens Suppl 6 (1988) S148-S150
27. Greenwood J.P., Scott E.M., Stoker J.B., and Mary D.A. Hypertensive left ventricular hypertrophy: Relation to peripheral sympathetic drive. J Am Coll Cardiol 38 (2001) 1711-1717
28. Devereux R.B., Dahlof B., Gerdts E., et al. Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) Trial. Circulation 110 (2004) 1456-1462
29. Perticone F., Ceravolo F., Cosco C., et al. Deletion polymorphism of angiotensin-converting enzyme gene and left ventricular hypertrophy in southern Italian patients. J Am Coll Cardiol 29 (1997) 365-369
30. Pitt B., Zannad F., Phillips R.A., et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4E-Left Ventricular Hypertrophy Study. Circulation 108 (2003) 1831-1838
31. Verdecchia P., Reboldi G., Schillaci G., et al. Circulating insulin and insulin growth factor-1 are independent determinants of left ventricular mass and geometry in essential hypertension. Circulation 100 (1999) 1802-1807
32. Ceravolo R., Maio R., Cuda G., et al. Relation of fasting insulin related to insertion/deletion polymorphism of angiotensin-converting enzyme-gene and cardiac mass in never-treated patients with systemic hypertension. Am J Cardiol 92 (2003) 1234-1237
33. Sesti G., Sciacqua A., Scozzafava A., et al. Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients. J Hypertens 25 (2007) 471-477
34. Gonzalez A., Lopez B., Martin-Raymondi D., et al. Usefulness of plasma cardiotrophin-1 in assessment of left ventricular hypertrophy regression in hypertensive patients. J Hypertens 23 (2005) 2297-2304
35. Sciacqua A., Scozzafava A., Pujia A., et al. Interaction between vascular dysfunction and cardiac mass increases the risk of cardiovascular outcomes in essential hypertension. Eur Heart J 26 (2005) 921-927
36. Sciacqua A., Borrello F., Vatrano M., Grembiale R.D., and Perticone F. Effect of interaction between left ventricular dysfunction and endothelial function in hypertension. Curr Hypertens Rep 8 (2006) 212-218
37. Arnett D.K., de las F.L., and Broeckel U. Genes for left ventricular hypertrophy. Curr Hypertens Rep 6 (2004) 36-41
38. Perticone F., Maio R., Di Paola R., et al. Role of PC-1 and ACE genes on insulin resistance and cardiac mass in never-treated hypertensive patients. Suggestive evidence for a digenic additive modulation. Nutr Metab Cardiovasc Dis 17 (2007) 181-186
39. Dell'Omo G., Penno G., Giorgi D., Di Bello V., Mariani M., and Pedrinelli R. Association between high-normal albuminuria and risk factors for cardiovascular and renal disease in essential hypertensive men. Am J Kidney Dis 40 (2002) 1-8
40. Watanabe S., Okura T., Liu J., et al. Serum cystatin C level is a marker of end-organ damage in patients with essential hypertension. Hypertens Res 26 (2003) 895-899
41. Leoncini G., Viazzi F., Parodi D., et al. Mild renal dysfunction and cardiovascular risk in hypertensive patients. J Am Soc Nephrol 15 suppl 1 (2004) S88-S90
42. Zoccali C. Traditional and emerging cardiovascular and renal risk factors: An epidemiologic perspective. Kidney Int 70 (2006) 26-33
43. Fliser D., Pacini G., Engelleiter R., et al. Insulin resistance and hyperinsulinemia are already present in patients with incipient renal disease. Kidney Int 53 (1998) 1343-1347
44. Salles G.F., Fiszman R., Cardoso C.R., and Muxfeldt E.S. Relation of left ventricular hypertrophy with systemic inflammation and endothelial damage in resistant hypertension. Hypertension 50 (2007) 723-728
45. Perticone F., Maio R., Tripepi G., and Zoccali C. Endothelial dysfunction and mild renal insufficiency in essential hypertension. Circulation 110 (2004) 821-825
46. Zoccali C., Maio R., Tripepi G., Mallamaci F., and Perticone F. Inflammation as a mediator of the link between mild to moderate renal insufficiency and endothelial dysfunction in essential hypertension. J Am Soc Nephrol 17 suppl 2 (2006) S64-S68