A new DNA analogue with expanded size and scope

ChemBioChem

Volumn 5, Issue 6, 2004, Pages 765-767

  Heckel, Alexander ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

DNA analogues; Nucleic acids; Nucleobases; Nucleotides

Indexed keywords

ADENINE; BENZENE; DNA; DOUBLE STRANDED DNA; NUCLEIC ACID BASE; NUCLEOSIDE; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; THYMINE;

CIRCULAR DICHROISM; DNA BINDING; DNA DENATURATION; DNA SEQUENCE; DNA STRUCTURE; DNA SYNTHESIS; HYDROGEN BOND; MELTING POINT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SHORT SURVEY;

BASE PAIRING; BASE SEQUENCE; DNA; DNA REPEAT EXPANSION; HYDROGEN BONDING; MODELS, MOLECULAR;

EID: 4544377419     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200400001     Document Type: Short Survey

References (21)

1. J. D. Watson, F. H. C. Crick, Nature 1953, 171, 737-738.
2. J. D. Watson, F. H. C. Crick, Nature 1953, 171, 964-967.
3. E. T. Kool, Chem. Rev. 1997, 97, 1473-1487.
4. S. A. Benner, T. R. Battersby, B. Eschgfäller, D. Mutter, J. T. Kodra, S. Lutz, T. Arslan, D. K. Bäschlin, M. Blättler, M. Egli, C. Hammer, H. A. Held, J. Horlacher, Z. Huang, B. Hydrup, T. F. Jenny, S. C. Jurczyk, M. König, U. v. Krosigk, M. J. Lutz, L. J. MacPherson, S. E. Moroney, E. Müller, K. P. Nambiar, J. A. Piccirilli, C. Y. Switzer, J. J. Vögel, C. Richert, A. L. Roughton, J. Schmidt, K. C. Schneider, J. Stackhouse, Pure Appl. Chem. 1998, 70, 263-266.
5. J. D. Bain, C. Switzer, A. R. Chamberlin, S. A. Benner, Nature 1992, 356, 537-539.
6. O. Thum, S. Jäger, M. Famulok, Angew. Chem. 2001, 113, 4112-4115; Angew. Chem. Int. Ed. 2001, 40, 3990-3993.
7. O. Thum, S. Jäger, M. Famulok, Angew. Chem. 2001, 113, 4112-4115; Angew. Chem. Int. Ed. 2001, 40, 3990-3993.
8. K. Groebke, J. Hunziker, W. Fraser, L. Peng, U. Diederichsen, K. Zimmermann, A. Holzner, C. Leumann, A. Eschenmoser, Helv. Chim. Acta 1998, 81, 375-474.
9. S. Verma, F. Eckstein, Annu. Rev. Biochem. 1998, 67, 99-134.
10. P. E. Nielsen, Acc. Chem. Res. 1999, 32, 624-630.
11. E. Uhlmann, A. Peyman, G. Breipohl, D. W. Will, Angew. Chem. 1998, 110, 2954-2983; Angew. Chem. Int. Ed. 1998, 37, 2796-2823.
12. E. Uhlmann, A. Peyman, G. Breipohl, D. W. Will, Angew. Chem. 1998, 110, 2954-2983; Angew. Chem. Int. Ed. 1998, 37, 2796-2823.
13. J. Heasman, Dev. Biol. (San Diego CA U.S.) 2002, 243, 209-214.
14. A. A. Koshkin, S. K. Singh, P. Nielsen, V. K. Rajwanshi, R. Kumar, M. Meldgaard, C. E. Olsen, J. Wengel, Tetrahedron 1998, 54, 3607-3630.
15. D.-R. Ahn, A. Egger, C. Lehmann, S. Pitsch, C. J. Leumann, Chem. Eur. J. 2002, 8, 5312-5322.
16. E. Uhlmann, A. Peyman, Chem. Rev. 1990, 90, 544-584.
17. H. Liu, J. Gao, S. R. Lynch, Y. D. Saito, L. Maynard, E. T. Kool, Science 2003, 302, 868-871. For a more detailed description of the synthesis and properties of the single nucleobases xA and xT see also; H. Liu, J. Gao, L. Maynard, Y. D. Saito, E. T. Kool, J. Am. Chem. Soc. 2004, 126, 1102-1109.
18. H. Liu, J. Gao, S. R. Lynch, Y. D. Saito, L. Maynard, E. T. Kool, Science 2003, 302, 868-871. For a more detailed description of the synthesis and properties of the single nucleobases xA and xT see also; H. Liu, J. Gao, L. Maynard, Y. D. Saito, E. T. Kool, J. Am. Chem. Soc. 2004, 126, 1102-1109.
19. G. Prakash, E. T. Kool, J. Am. Chem. Soc. 1992, 114, 3523-3527.
20. Both representations of the duplexes show a Conolly surface with a probe radius of 1.4 Å. The images were generated with VMD 1.8.2 (http://www.ks.uiuc.edu/Research/vmd).
21. P. B. Dervan, Bioorg. Med. Chem. 2001, 9, 2215-2235.