In vivo imaging of MLC2v-luciferase, a cardiac-specific reporter gene expression in mice

Academic Radiology

Volumn 11, Issue 9, 2004, Pages 1022-1028

  Gruber, Peter J ^b   Li, Zijun ^a   Li, Hui ^a   Worrad, Diane ^b   Huang, Bin ^a   Abdullah, Ibrahim ^b   Wang, Wenge ^a   El Deiry, Wafik ^a   Ferrari, Victor A ^a   Zhou, Rong ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c Department of Radiology   (United States)

Author keywords

bioluminescence; cardiac; Cardiac ventricular myosin light chain 2 (MLC2v); luciferase; reporter gene

Indexed keywords

LUCIFERASE; PHOSPHATE; PLASMID DNA; PLASMID VECTOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG; VENTRICULAR MYOSIN; VENTRICULAR MYOSIN LIGHT CHAIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; AUTOPSY; BIOLUMINESCENCE; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION; HEART MUSCLE; IMAGING SYSTEM; MARKER GENE; MOLECULAR CLONING; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; STERNOTOMY;

ANIMALS; CARDIAC MYOSINS; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; GENETIC VECTORS; HEART; LUCIFERASES; MICE; MICE, INBRED C57BL; MYOSIN LIGHT CHAINS; PLASMIDS; PROMOTER REGIONS (GENETICS);

EID: 4544353817     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acra.2004.05.022     Document Type: Article

References (21)

1. V. Ponomarev, M. Doubrovin, I. Serganova Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging Neoplasia 5 2003 245 254
2. P. Ray, A. De, J.J. Min, R.Y. Tsien, S.S. Gambhir Imaging tri-fusion multimodality reporter gene expression in living subjects Cancer Res 64 2004 1323 1330
3. P.R. Contag, I.N. Olomu, D.K. Stevenson, C.H. Contag Bioluminescent indicators in living mammals Nat Med 4 1998 245 247
4. S.S. Gambhir, E. Bauer, M.E. Black A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography Proc Natl Acad Sci U S A 97 2000 2785 2790
5. J.G. Tjuvajev, A. Joshi, J. Callegari A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase Neoplasia 1 1999 315 320
6. R. Weissleder, A. Moore, U. Mahmood, R. Bhorade, H. Benveniste, E.A. Chiocca, J.P. Basilion In vivo magnetic resonance imaging of transgene expression Nat Med 6 2000 351 355
7. A. Auricchio, R. Zhou, J.M. Wilson, J.D. Glickson In vivo detection of gene expression in liver by 31P nuclear magnetic resonance spectroscopy employing creatine kinase as a marker gene Proc Natl Acad Sci U S A 98 2001 5205 5210
8. P. Stanely L. Kricka Bioluminescence and Chemiluninescence Current Status 1991 John Wiley and Sons Chichester, NY
9. R. von Harsdorf, R.J. Schott, Y.T. Shen, S.F. Vatner, V. Mahdavi, B. Nadal-Ginard Gene injection into canine myocardium as a useful model for studying gene expression in the heart of large mammals Circ Res 72 1993 688 695
10. D. Gal, L. Weir, G. Leclerc, J.G. Pickering, J. Hogan, J.M. Isner Direct myocardial transfection in two animal models. Evaluation of parameters affecting gene expression and percutaneous gene delivery Lab Invest 68 1993 18 25
11. K. Li, R.E. Welikson, K.L. Vikstrom, L.A. Leinwand Direct gene transfer into the mouse heart J Mol Cell Cardiol 29 1997 1499 1504
12. P.M. Buttrick, A. Kass, R.N. Kitsis, M.L. Kaplan, L.A. Leinwand Behavior of genes directly injected into the rat heart in vivo Circ Res 70 1992 193 198
13. J.C. Wu, M. Inubushi, G. Sundaresan, H.R. Schelbert, S.S. Gambhir Optical imaging of cardiac reporter gene expression in living rats Circulation 105 2002 1631 1634
14. T.X. OBrien, K.J. Lee, K.R. Chien Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube Proc Natl Acad Sci U S A 90 1993 5157 5161
15. K.J. Lee, R.S. Ross, H.A. Rockman Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene J Biol Chem 267 1992 15875 15885
16. S.A. Henderson, M. Spencer, A. Sen, C. Kumar, M.A. Siddiqui, K.R. Chien Structure, organization, and expression of the rat cardiac myosin light chain-2 gene. Identification of a 250-base pair fragment which confers cardiac-specific expression J Biol Chem 264 1989 18142 18148
17. J.C. Wu, G. Sundaresan, M. Iyer, S.S. Gambhir Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice Mol Ther 4 2001 297 306
18. W.M. Franz, T. Rothmann, N. Frey, H.A. Katus Analysis of tissue-specific gene delivery by recombinant adenoviruses containing cardiac-specific promoters Cardiovasc Res 35 1997 560 566
19. W.M. Franz, D. Breves, K. Klingel, G. Brem, P.H. Hofschneider, R. Kandolf Heart-specific targeting of firefly luciferase by the myosin light chain-2 promoter and developmental regulation in transgenic mice Circ Res 73 1993 629 638
20. M.I. Phillips, Y. Tang, K. Schmidt-Ott, K. Qian, S. Kagiyama Vigilant vector Heart-specific promoter in an adeno-associated virus vector for cardioprotection Hypertension 39 2002 651 655
21. N. Meyer, M. Jaconi, A. Landopoulou, P. Fort, M. Puceat A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells FEBS Lett 478 2000 151 158