Formulation of a poorly soluble drug using hot melt extrusion. The amorphous state as an alternative

American Pharmaceutical Review

Volumn 7, Issue 4, 2004, Pages 88-92

  Alvarez Núñez, Fernando A ^a   Leonard, Mark R ^a,b  

^a PFIZER INC   (United States)

^b PLIVA Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; POLYMER;

CHEMICAL ANALYSIS; CHEMICAL PROCEDURES; CONCENTRATION (PARAMETERS); DISPERSION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG SOLUBILITY; DRUG STABILITY; REVIEW; TABLET; TEMPERATURE DEPENDENCE; THERMOSTABILITY;

EID: 4544352052     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (10)

1. Venkatesh, S. and Lipper, R.A. The Role of the Development Scientist in Compound Lead Selection and Optimization. J. Pharm. Sci. 89, (2000) 145.
2. Hörter D. and Dressman, J.B. Influence of Physicochemical Properties on Dissolution of Drugs in the Gastrointestinal Tract. Adv. Drug Delivery Revs. 46 (2001) 75.
3. Yu, L. Amorphous Pharmaceutical Solids: Preparation, Characterization, and Stabilization. Adv. Drug Delivery Revs. 48 (2001) 27.
4. Levin, H. Ed. Amorphous Food and Pharmaceutical Systems RSC, Cambridge 2002.
5. Serajuddin, A. T. Solid Dispersion of Poorly Water-Soluble Drugs: Early Promises, Subsequent Problems, Recent Breakthroughs. J. Pharm. Sci. 88 (1999) 1058.
6. Leuner, C. and Dressman, J.B. Improving Drug Solubility for Oral Delivery Using Solid Dispersions. Eur. J. Pharm. Biopharm. 50 (2000) 47.
7. Ghebre-Sellassie, I. and Martin, C. Pharmaceutical Extrusion Technology. Marcel Dekker, Inc. 2003.
8. Greenhalgh, D.J, Williams, A.C, Timmins, P., and York, P. Solubility Parameters as Predictors of Miscibility in Solid Dispe
9. Forster A., Hempenstall, J., Tucker, I., and Rades, T. Selection of Excipients for Melt Extrusion with Two Poorly Water-Soluble Drugs by Solubility Parameter Calculation and Thermal Analysis. Int. J. Pharm. 226 (2001) 147.
10. Alvarez-Nunez, F.A, Leonard, M. R., and Crawford, L.F. Glass Transition Temperature Measurements as Predictors of the Physical Stability of a Poorly Soluble Pharmaceutical Agent Formulated as a Solid Dispersion. AAPS 2002, Toronto, ON.