메뉴 건너뛰기




Volumn 4, Issue 9, 2004, Pages 1473-1481

Allergy vaccines - New approaches to an old concept

Author keywords

Allergy vaccines; Alum; Blocking antibody; CpG; IFN ; IgE; IgG; IL 4; IL 5; ISS; Monophosphoryl lipid A; Notch receptors; T reg; Th1; Th2; Toll like receptors; Tyrosine

Indexed keywords

ADJUVANT; ALLERGEN; ALLERGY VACCINE; ALUMINUM HYDROXIDE; ALUMINUM POTASSIUM SULFATE; BACTERIAL DNA; CYTOKINE; DIPHTHERIA TOXOID; GAMMA INTERFERON; GLUTARALDEHYDE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G4; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; LIPOSOME; MICROSPHERE; MONOPHENOL MONOOXYGENASE; MPL; MUTEIN; NOTCH RECEPTOR; PHOSPHORYL LIPID A; POLLEN ANTIGEN; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 4544313426     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.4.9.1473     Document Type: Review
Times cited : (31)

References (41)
  • 1
    • 0035546144 scopus 로고    scopus 로고
    • Why are allergies increasing?
    • RING J, KRÄMER U, SCHÄFER T et al.: Why are allergies increasing? Curr. Opin. Immunol. (2001) 13(6):701-708. An objective discussion of the various hypotheses and forms of evidence as explanations for the present worldwide explosion in allergy.
    • (2001) Curr. Opin. Immunol. , vol.13 , Issue.6 , pp. 701-708
    • Ring, J.1    Krämer, U.2    Schäfer, T.3
  • 2
    • 0036232099 scopus 로고    scopus 로고
    • Low prevalence of atopy in young Danish farmers and farming students born and raised on a farm
    • PORTENGEN L, SIGSGAARD T, OMLAND O, HJORT C, HEEDERIK D, DOEKES G: Low prevalence of atopy in young Danish farmers and farming students born and raised on a farm. Clin. Exp. Allergy (2002) 32(2):247-253. This paper endorses earlier studies regarding the 'protective effect' of a farm environment for the development of allergies.
    • (2002) Clin. Exp. Allergy , vol.32 , Issue.2 , pp. 247-253
    • Portengen, L.1    Sigsgaard, T.2    Omland, O.3    Hjort, C.4    Heederik, D.5    Doekes, G.6
  • 3
    • 0035495430 scopus 로고    scopus 로고
    • Are infections protecting from atopy?
    • MATRICARDI PM, RONCHETTI R: Are infections protecting from atopy? Curr. Opin. Allergy Clin. Immunol. (2001) 1(5):413-419. Provides additional support for the hygiene hypothesis of allergy.
    • (2001) Curr. Opin. Allergy Clin. Immunol. , vol.1 , Issue.5 , pp. 413-419
    • Matricardi, P.M.1    Ronchetti, R.2
  • 4
    • 0002123367 scopus 로고
    • The immunising cure of hay fever
    • New York, USA
    • CURTIS HH: The immunising cure of hay fever. Medical News. New York, USA (1900) 77:16.
    • (1900) Medical News , vol.77 , pp. 16
    • Curtis, H.H.1
  • 5
    • 50249230114 scopus 로고
    • Prophylactic inoculation against hay fever
    • NOON L: Prophylactic inoculation against hay fever. Lancet (1911) 1:1572.
    • (1911) Lancet , vol.1 , pp. 1572
    • Noon, L.1
  • 6
    • 0001815978 scopus 로고
    • The antigenic value of toxoid precipitated by potassium alum
    • GLENNY AT, POPE CG, WADDINGTON H et al.: The antigenic value of toxoid precipitated by potassium alum. J. Path. Bact. (1926) 29:38.
    • (1926) J. Path. Bact. , vol.29 , pp. 38
    • Glenny, A.T.1    Pope, C.G.2    Waddington, H.3
  • 7
    • 0006870518 scopus 로고
    • Treatment of hay-fever with alum-precipitated pollen
    • SLEDGE RF: Treatment of hay-fever with alum-precipitated pollen. US Naval Med. Bull. (1938) 36:18. The first use of an adjuvant for AV.
    • (1938) US Naval Med. Bull. , vol.36 , pp. 18
    • Sledge, R.F.1
  • 8
    • 0035194832 scopus 로고    scopus 로고
    • Immunological adjuvants in allergy vaccines: Past, present and future
    • WHEELER AW, WORONIECKI SR: Immunological adjuvants in allergy vaccines: past, present and future. Allergol. Int. (2001) 50:295-301.
    • (2001) Allergol. Int. , vol.50 , pp. 295-301
    • Wheeler, A.W.1    Woroniecki, S.R.2
  • 9
    • 0035144140 scopus 로고    scopus 로고
    • The common vaccine adjuvant aluminium hydroxide upregulates accessory properties of human monocytes via an interleukin-4-dependent mechanism
    • ULANOVA M, TARKOWSKI A, HAHN-ZORIC M et al.: The common vaccine adjuvant aluminium hydroxide upregulates accessory properties of human monocytes via an interleukin-4-dependent mechanism. Infect. Immun. (2001) 69(2):1151-1159.
    • (2001) Infect. Immun. , vol.69 , Issue.2 , pp. 1151-1159
    • Ulanova, M.1    Tarkowski, A.2    Hahn-Zoric, M.3
  • 10
    • 0031784380 scopus 로고    scopus 로고
    • Immunologic changes associated with allergen immunotherapy
    • DURHAM SR, TILL SJ: Immunologic changes associated with allergen immunotherapy. J. Allergy Clin. Immunol. (1998) 102:157-164. This paper illustrated the importance of the Th2 to Th1 switch in AV.
    • (1998) J. Allergy Clin. Immunol. , vol.102 , pp. 157-164
    • Durham, S.R.1    Till, S.J.2
  • 11
    • 0034110867 scopus 로고    scopus 로고
    • Mechanisms of allergen-specific immunotherapy
    • AKDIS CA, BLASER K: Mechanisms of allergen-specific immunotherapy. Allergy (2000) 55:522-530.
    • (2000) Allergy , vol.55 , pp. 522-530
    • Akdis, C.A.1    Blaser, K.2
  • 12
    • 0043264799 scopus 로고    scopus 로고
    • Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: Reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies
    • MOTHES N, HEINZKILL M, DRACHENBERG KJ et al.: Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin. Exp. Allergy (2003) 33:1198-1208. Resurrection of the blocking antibody theory.
    • (2003) Clin. Exp. Allergy , vol.33 , pp. 1198-1208
    • Mothes, N.1    Heinzkill, M.2    Drachenberg, K.J.3
  • 13
    • 0041735323 scopus 로고    scopus 로고
    • Induction of 'blocking' IgG antibodies during immunotherapy
    • WACHHOLZ PA, DURHAM SR: Induction of 'blocking' IgG antibodies during immunotherapy. Clin. Exp. Allergy (2003) 33:1171-1174.
    • (2003) Clin. Exp. Allergy , vol.33 , pp. 1171-1174
    • Wachholz, P.A.1    Durham, S.R.2
  • 14
    • 0037435928 scopus 로고    scopus 로고
    • Liposomes and ISCOMS
    • KERSTEN GF, CROMMELIN DJ: Liposomes and ISCOMS. Vaccine (2003) 21 (9-10):915-920.
    • (2003) Vaccine , vol.21 , Issue.9-10 , pp. 915-920
    • Kersten, G.F.1    Crommelin, D.J.2
  • 15
    • 0036436280 scopus 로고    scopus 로고
    • Liposome-entrapped D. pteronyssinus vaccination in mild asthma patients: Effect of 1-year double-blind, placebo-controlled trial on inflammation, bronchial hyper responsiveness and immediate and late bronchial responses to the allergen
    • ALVAREZ MJ, ECHECHIPIA S, GARCIA B et al.: Liposome-entrapped D. pteronyssinus vaccination in mild asthma patients: effect of 1-year double-blind, placebo-controlled trial on inflammation, bronchial hyper responsiveness and immediate and late bronchial responses to the allergen. Clin. Exp. Allergy (2002) 32(11):1574-1582.
    • (2002) Clin. Exp. Allergy , vol.32 , Issue.11 , pp. 1574-1582
    • Alvarez, M.J.1    Echechipia, S.2    Garcia, B.3
  • 16
    • 0028926175 scopus 로고
    • Biodegradable microparticles as a delivery system for the allergens of Dermatophagoides pteronysssinus (house dust mite): 1. Preparation and characterization of microparticles
    • SHARIF S, WHEELER AW, O'HAGAN DT: Biodegradable microparticles as a delivery system for the allergens of Dermatophagoides pteronysssinus (house dust mite): 1. Preparation and characterization of microparticles. Int. J. Pharm. (1995) 119:239-246.
    • (1995) Int. J. Pharm. , vol.119 , pp. 239-246
    • Sharif, S.1    Wheeler, A.W.2    O'Hagan, D.T.3
  • 17
    • 0014988001 scopus 로고
    • Preparation and properties of 'allergoids' derived from native pollen allergens by mild formalin treatment
    • MARSH DG: Preparation and properties of 'allergoids' derived from native pollen allergens by mild formalin treatment. Int. Arch. Allergy Appl. Immunol. (1971) 4(1):199-215. The first attempt to produce newer and safer forms of allergens, termed allergoids, by chemical modification.
    • (1971) Int. Arch. Allergy Appl. Immunol. , vol.4 , Issue.1 , pp. 199-215
    • Marsh, D.G.1
  • 20
    • 1842527238 scopus 로고    scopus 로고
    • Can we genetically engineer safer and more effective immunotherapy reagents?
    • WESTRITSCHNIG K, VALENTA R: Can we genetically engineer safer and more effective immunotherapy reagents? Curr. Opin. Allergy Clin. Immunol. (2003) 3(6):495-500.
    • (2003) Curr. Opin. Allergy Clin. Immunol. , vol.3 , Issue.6 , pp. 495-500
    • Westritschnig, K.1    Valenta, R.2
  • 21
    • 0028893179 scopus 로고
    • Isoforms of Bet v 1, the major birch pollen allergen, analysed by liquid chromatography, mass spectrometry, and cDNA cloning
    • SWOBODA I, JILEK A, FERREIRA F et al.: Isoforms of Bet v 1, the major birch pollen allergen, analysed by liquid chromatography, mass spectrometry, and cDNA cloning. J. Biol. Chem (1995) 2,70(6):2607-2613.
    • (1995) J. Biol. Chem. , vol.2 , Issue.6 , pp. 2607-2613
    • Swoboda, I.1    Jilek, A.2    Ferreira, F.3
  • 22
    • 10744226783 scopus 로고    scopus 로고
    • Vaccines for birch pollen allergy based on genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1
    • MAHLER V, VRTLA S, KUSS O et al.: Vaccines for birch pollen allergy based on genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1. Clin. Exp. Allergy (2004) 34(1):115-122. An interesting and scientifically elegant approach to AV.
    • (2004) Clin. Exp. Allergy , vol.34 , Issue.1 , pp. 115-122
    • Mahler, V.1    Vrtla, S.2    Kuss, O.3
  • 23
    • 8044227212 scopus 로고    scopus 로고
    • Treatment of cat allergy with T-cell reactive peptides
    • NORMAN PS, OHMAN JL, LONG AA et al.: Treatment of cat allergy with T-cell reactive peptides. Am. J. Respir. Crit. Care Med. (1996) 154:1623-1628. Early studies on peptides for immunotherapy.
    • (1996) Am. J. Respir. Crit. Care Med. , vol.154 , pp. 1623-1628
    • Norman, P.S.1    Ohman, J.L.2    Long, A.A.3
  • 24
    • 2442529551 scopus 로고    scopus 로고
    • New approaches to immunotherapy: Allergen-derived peptides
    • LARCHE M: New approaches to immunotherapy: allergen-derived peptides. Immunol. Allergy (CPD Bulletin) (2004) 3(3):73-76. A short but useful review on T cell-reactive peptides in immunotherapy.
    • (2004) Immunol. Allergy (CPD Bulletin) , vol.3 , Issue.3 , pp. 73-76
    • Larche, M.1
  • 25
    • 0031866059 scopus 로고    scopus 로고
    • Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom
    • MUELLER U, AKDIS CA, FRICKER M et al.: Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J. Allergy Clin. Immunol. (1998) 101:747-754. A study supporting the use of non-IgE-reactive T cell epitope-containing peptides for vaccination.
    • (1998) J. Allergy Clin. Immunol. , vol.101 , pp. 747-754
    • Mueller, U.1    Akdis, C.A.2    Fricker, M.3
  • 26
    • 0033031080 scopus 로고    scopus 로고
    • Deviation of the allergic IgE to an IgG response by gene immunotherapy
    • RAZ E, SPIEGELBERG HL: Deviation of the allergic IgE to an IgG response by gene immunotherapy. Int. Rev. Immunol. (1999) 18:271-289.
    • (1999) Int. Rev. Immunol. , vol.18 , pp. 271-289
    • Raz, E.1    Spiegelberg, H.L.2
  • 27
    • 0343953087 scopus 로고    scopus 로고
    • Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity
    • TIGH H, TAKABAYASHI K, SCHWARTZ D et al.: Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity. J. Allergy Clin. Immunol. (2000) 106:124-134.
    • (2000) J. Allergy Clin. Immunol. , vol.106 , pp. 124-134
    • Tigh, H.1    Takabayashi, K.2    Schwartz, D.3
  • 28
    • 0033461117 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotide induces Th1 immune response and inhibition of IgE antibody production to cedar pollen allergens in mice
    • KOHAMA Y, AKIZUKI O, HAGIKARI K, YAMADA E, YAMAMOTO H: Immunostimulatory oligodeoxynucleotide induces Th1 immune response and inhibition of IgE antibody production to cedar pollen allergens in mice. J. Allergy Clin. Immunol. (1999) 104:1231-1238. Interesting studies of the Th1-inducing properties of bacterial ISSs.
    • (1999) J. Allergy Clin. Immunol. , vol.104 , pp. 1231-1238
    • Kohama, Y.1    Akizuki, O.2    Hagikari, K.3    Yamada, E.4    Yamamoto, H.5
  • 30
    • 0029201182 scopus 로고
    • Monophosphoryl lipid A as an adjuvant. Past experiences and new directions
    • Powell MF, Mewman MJ (Eds), Plenum Press, New York, USA
    • ULRICH JT, MYERS KR: Monophosphoryl lipid A as an adjuvant. Past experiences and new directions. In: Vaccine designs. The sub-unit and adjuvant approach. Powell MF, Mewman MJ (Eds), Plenum Press, New York, USA (1995):495-524. An important review of the production and properties of a clinically acceptable Th1 adjuvant.
    • (1995) Vaccine Designs. The Sub-unit and Adjuvant Approach , pp. 495-524
    • Ulrich, J.T.1    Myers, K.R.2
  • 31
    • 0037407849 scopus 로고    scopus 로고
    • Role of innate immune factors in the adjuvant activity of monophosphoryl lipid A
    • MARTIN M, MICHALEK SM, KATZ J: Role of innate immune factors in the adjuvant activity of monophosphoryl lipid A. Infect. Immun. (2003) 71(5):2498-2507. This paper details evidence for cellular mechanisms (including activation of TLR2 and TLR4) by which MPL induces host cell activation.
    • (2003) Infect. Immun. , vol.71 , Issue.5 , pp. 2498-2507
    • Martin, M.1    Michalek, S.M.2    Katz, J.3
  • 32
    • 0035208015 scopus 로고    scopus 로고
    • A Th1-inducing adjuvant, MPL®, enhances antibody profiles in experimental animals suggesting it has the potential to improve the efficacy of allergy vaccines
    • WHEELER AW, MARSHALL JS, ULRICH JT: A Th1-inducing adjuvant, MPL®, enhances antibody profiles in experimental animals suggesting it has the potential to improve the efficacy of allergy vaccines. Int. Arch. Allergy Immunol. (2001) 126:135-139. This is an interesting study showing that tyrosine and MPL can act synergistically to produce a Th1 response with model antigens.
    • (2001) Int. Arch. Allergy Immunol. , vol.126 , pp. 135-139
    • Wheeler, A.W.1    Marshall, J.S.2    Ulrich, J.T.3
  • 33
    • 0034995781 scopus 로고    scopus 로고
    • A well-tolerated grass pollen specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseason injections
    • DRACHENBERG KJ, WHEELER AW, STUEBNER P, HORAK F: A well-tolerated grass pollen specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseason injections. Allergy (2001) 56:498-505. A very important clinical study showing how incorporation of a Th1 adjuvant can reduce the number of injections required to obtain efficacy.
    • (2001) Allergy , vol.56 , pp. 498-505
    • Drachenberg, K.J.1    Wheeler, A.W.2    Stuebner, P.3    Horak, F.4
  • 34
    • 0242641243 scopus 로고    scopus 로고
    • Efficacy and tolerability of short-term specific immunotherapy with pollen allergoids adjuvant by monophosphoryl lipid A (MPL®) for children and adolescents
    • DRACHENBERG KJ, HEINZKILL M, URBAN E, WORONIECKI SR: Efficacy and tolerability of short-term specific immunotherapy with pollen allergoids adjuvant by monophosphoryl lipid A (MPL®) for children and adolescents. Allergol. Immunopathol. (2003) 31(5):270-277. Confirmation of the efficacy and safety of a Th1 adjuvanted allergy vaccine. AV may reduce the progression of allergic disease in children.
    • (2003) Allergol. Immunopathol. , vol.31 , Issue.5 , pp. 270-277
    • Drachenberg, K.J.1    Heinzkill, M.2    Urban, E.3    Woroniecki, S.R.4
  • 35
    • 0346849694 scopus 로고    scopus 로고
    • Notch and the immune system
    • MAILLARD I, ADLER SH, PEAR WS: Notch and the immune system. Immunity (2003) 19(6):781-791. A novel and very interesting approach to specific immunomodulation.
    • (2003) Immunity , vol.19 , Issue.6 , pp. 781-791
    • Maillard, I.1    Adler, S.H.2    Pear, W.S.3
  • 36
    • 0031817107 scopus 로고    scopus 로고
    • Allergen immunotherapy: Therapeutic vaccines for allergic diseases. A WHO position paper
    • BOUSQUET J, LOCKEY FR, MALLING H-J: Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. Allergy (1998) 53:1-42. A landmark paper providing ratification of AV as a mainstream method of treating allergy.
    • (1998) Allergy , vol.53 , pp. 1-42
    • Bousquet, J.1    Lockey, F.R.2    Malling, H.-J.3
  • 37
    • 18744423130 scopus 로고    scopus 로고
    • Sublingual immunotherapy for allergic rhinitis
    • WILSON DR, TORRES LIMA M, DURHAM SR: Sublingual immunotherapy for allergic rhinitis (Cochrane Review). In: The Cochrane Library, issue 2 (2003). Oxford: Update software. A very thorough statistical analysis of controlled sublingual immunotherapy studies concludes that the treatment may be safe and efficacious.
    • (2003) The Cochrane Library , Issue.2
    • Wilson, D.R.1    Torres Lima, M.2    Durham, S.R.3
  • 38
    • 0002756339 scopus 로고    scopus 로고
    • Monophosphoryl lipid A (MPL®) has Th1 stimulating properties in immunotherapy with birch pollen allergoid
    • KLIMEK L, STUCK B, HUNDORF J, SCHNEIDER-GENE S, HÖRMANN K: Monophosphoryl lipid A (MPL®) has Th1 stimulating properties in immunotherapy with birch pollen allergoid. Allergy (2001) 56(Suppl. 68):93. Provides good evidence of MPL inducing a ThI adjuvant effect.
    • (2001) Allergy , vol.56 , Issue.SUPPL. 68 , pp. 93
    • Klimek, L.1    Stuck, B.2    Hundorf, J.3    Schneider-Gene, S.4    Hörmann, K.5
  • 39
    • 0037497964 scopus 로고    scopus 로고
    • Immmunophenotypic characterization of peripheral B cells during short-term immunotherapy with tree pollen allergoid and the immunoadjuvant monophosphoryl lipid A
    • ROVER AC, REIMANN S, ZUBERBIER T, WORM M: Immmunophenotypic characterization of peripheral B cells during short-term immunotherapy with tree pollen allergoid and the immunoadjuvant monophosphoryl lipid A. J. Invest. Allergol. Clin. Immunol. (2002) 12(4):227-234. Provides good evidence of MPL inducing a Th1 adjuvant effect.
    • (2002) J. Invest. Allergol. Clin. Immunol. , vol.12 , Issue.4 , pp. 227-234
    • Rover, A.C.1    Reimann, S.2    Zuberbier, T.3    Worm, M.4
  • 40
    • 0006871445 scopus 로고    scopus 로고
    • Allergoid-specific cellular immune response as a possible marker for immunological in vitro effects of immunotherapy
    • VON BAEHR V, SCHERF HP, HERMES A: Allergoid-specific cellular immune response as a possible marker for immunological in vitro effects of immunotherapy. Allergy (2001) 56(Suppl.68):91. A publication supporting the use of allergoids, but with rather complex methodology.
    • (2001) Allergy , vol.56 , Issue.SUPPL. 68 , pp. 91
    • Von Baehr, V.1    Scherf, H.P.2    Hermes, A.3
  • 41
    • 4544341848 scopus 로고    scopus 로고
    • Monophosphoryl lipid A: In vitro effects on human T cell proliferation and cytokine production
    • PUGGIONI F, FRANCIS JN, DURHAM SR: Monophosphoryl lipid A: in vitro effects on human T cell proliferation and cytokine production. J. Allergy Clin. Immunol. (2003) 111(Pt2):333. Support for Th1 adjuvants from a prestigious group.
    • (2003) J. Allergy Clin. Immunol. , vol.111 , Issue.PART 2 , pp. 333
    • Puggioni, F.1    Francis, J.N.2    Durham, S.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.