Comparison of HLA-DR1-restricted T cell response induced in HLA-DR1 transgenic mice deficient for murine MHC class II and HLA-DR1 transgenic mice expressing endogenous murine MHC class II molecules

International Immunology

Volumn 16, Issue 9, 2004, Pages 1275-1282

  Pajot, Anthony ^a   Pancré, Véronique ^c   Fazilleau, Nicolas ^a   Michel, Marie Louise ^b   Angyalosi, Gerhild ^c   Ojcius, David M ^d   Auriault, Claude ^c   Lemonnier, François A ^a   Lone, Yu Chun ^a  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

^c Institut de Biologie   (France)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antigen; Major histocompatibility complex; Transgenic mice; Vaccine

Indexed keywords

CAPSID PROTEIN; CD4 ANTIGEN; EPITOPE; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; EPITOPE MAPPING; GENES, T-CELL RECEPTOR BETA; H-2 ANTIGENS; HEPATITIS B CORE ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HLA-DR1 ANTIGEN; HUMANS; MICE; MICE, TRANSGENIC;

EID: 4544311089     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh129     Document Type: Article

References (34)

1. Byrne, J. A. and Oldstone, M. B. 1984. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo. J. Virol. 51:682.
2. Taylor, P. M. and Askonas, B. A. 1986. Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo. Immunology 58:417.
3. Schulz, M., Zinkernagel, R. M. and Hengartner, H. 1991. Peptide-induced antiviral protection by cytotoxic T cells. Proc. Natl Acad. Sci. USA 88:991.
4. Shirai, M., Pendleton, C. D., Ahlers, J., Takeshita, T, Newman, M. and Berzofsky, J. A. 1994. Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs. J. Immunol. 152:549.
5. Ahlers, J. D., Dunlop, N., Pendleton, C. D., Newman, M., Nara, P. L. and Berzofsky, J. A. 1996. Candidate HIV type 1 multideterminant cluster peptide-P18MN vaccine constructs elicit type 1 helper T cells, cytotoxic Tcells and neutralizing antibody, all using the same adjuvant immunization. AIDS Res. Hum. Retroviruses 12:259.
6. Leist, T. P., Kohler, M. and Zinkernagel, R. M. 1989. Impaired generation of anti-viral cytotoxicity against lymphocytic choriomeningitis and vaccinia virus in mice treated with CD4-specific monoclonal antibody. Scand. J. Immunol. 30:679.
7. Eichelberger, M., Allan, W., Zijlstra, M., Jaenisch, R. and Doherty, P. C. 1991. Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. J. Exp. Med. 174:875.
8. Maloy, K. J., Burkhart, C., Freer, G. et al. 1999. Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection. J. Immunol. 162:2867.
9. Rotzschke, O., Falk, K., Deres, K., Schild, H., Norda, M., Metzger, J., Jung, G. and Rammensee, H. G. 1990. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature 348:252.
10. Vitiello, A., Marchesini, D., Furze, J., Sherman, L. A. and Chesnut, R. W. 1991. Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex. J. Exp. Med. 173:1007.
11. Pascolo, S., Bervas, N., Ure, J. M., Smith, A. G., Lemonnier, F. A. and Perarnau, B. 1997. HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J. Exp. Med. 185:2043.
12. Firat, H., Garcia-Pons, F., Tourdot, S. et al. 1999. H-2 class I knockout, HLA-A2.1-transgenic mice: a versatile animal model for preclinical evaluation of antitumor immunotherapeutic strategies. Eur. J. Immunol. 29:3112.
13. Firat, H., Cochet, M., Rohrlich, P. S., Garcia-Pons, F., Darche, S., Danos, O., Lemonnier, F. A. and Langlade-Demoyen, P. 2002. Comparative analysis of the CD8(+) T cell repertoires of H-2 class I wild-type/HLA-A2.1 and H-2 class I knockout/HLA-A2.1 transgenic mice. Int. Immunol. 14:925.
14. Gallez-Hawkins, G., Villacres, M. C., Li, X., Sanborn, M. C., Lomeli, N. A. and Zaia, J. A. 2003. Use of transgenic HLA A* 0201/Kb and HHD II mice to evaluate frequency of cytomegalovirus IE1-derived peptide usage in eliciting human CD8 cytokine response. J. Virol. 77:4457.
15. Kalams, S. A. and Walker, B. D. 1998. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J. Exp. Med. 188:2199.
16. Wang, J. C. and Livingstone, A. M. 2003. Cutting edge: CD4+ Tcell help can be essential for primary CD8+ T cell responses in vivo. J. Immunol. 171:6339.
17. Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G. and Schoenberger, S. P. 2003. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 421:852.
18. Johansen, P., Stamou, P., Tascon, R. E., Lowrie, D. B. and Stockinger, B. 2004. CD4 T cells guarantee optimal competitive fitness of CD8 memory T cells. Eur. J. Immunol. 34:91.
19. Altmann, D. M., Douek, D. C., Frater, A. J., Hetherington, C. M., Inoko, H. and Elliott, J. I. 1995. The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4. J. Exp. Med. 181:867.
20. Cosgrove, D., Gray, D., Dierich, A., Kaufman, J., Lemeur, M., Benoist, C. and Mathis, D. 1991. Mice lacking MHC class II molecules. Cell 66:1051.
21. Pannetier, C., Cochet, M., Darche, S., Casrouge, A., Zoller, M. and Kourilsky, P. 1993. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc. Natl Acad. Sci. USA 90:4319.
22. Michel, M. L., Pontisso, P., Sobczak, E., Malpiece, Y., Streeck, R. E. and Tiollais, P. 1984. Synthesis in animal cells of hepatitis B surface antigen particles carrying a receptor for polymerized human serum albumin. Proc. Natl Acad. Sci. USA 81:7708.
23. Brosterhus, H., Brings, S., Leyendeckers, H., Manz, R. A., Miltenyi, S., Radbruch, A., Assenmacher, M. and Schmitz, J. 1999. Enrichment and detection of live antigen-specific CD4(+) and CD8(+) T cells based on cytokine secretion. Eur. J. Immunol. 29:4053.
24. Ureta-Vidal, A., Firat, H., Perarnau, B. and Lemonnier, F. A. 1999. Phenotypical and functional characterization of the CD8+ T cell repertoire of HLA-A2.1 transgenic, H-2KbnullDbnull double knockout mice. J. Immunol. 163:2555.
25. Wilson, C. C., Palmer, B., Southwood, S. et al. 2001. Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes. J. Virol. 75:4195.
26. Boritz, E., Palmer, B. E., Livingston, B., Sette, A. and Wilson, C. C. 2003. Diverse repertoire of HIV-1 p24-specific, IFN-gamma-producing CD4+ T cell clones following immune reconstitution on highly active antiretroviral therapy. J. Immunol. 170:1106.
27. Woods, A., Chen, H. Y., Trumbauer, M. E., Sirotina, A., Cummings, R. and Zaller, D. M. 1994. Human major histocompatibility complex class II-restricted T cell responses in transgenic mice. J. Exp. Med. 180:173.
28. Kong, Y. M., David, C. S., Lomo, L. C., Fuller, B. E., Motte, R. W. and Giraldo, A. A. 1997. Role of mouse and human class II transgenes in susceptibility to and protection against mouse autoimmune thyroiditis. Immunogenetics 46:312.
29. Nabozny, G. H., Baisch, J. M., Cheng, S., Cosgrove, D., Griffiths, M. M., Luthra, H. S. and David, C. S. 1996. HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J. Exp. Med. 183:27.
30. Geluk, A., Taneja, V., van Meijgaarden, K. E., Zanelli, E., Abou-Zeid, C., Thole, J. E., de Vries, R. R., David, C. S. and Ottenhoff, T. H. 1998. Identification of HLA class II-restricted determinants of Mycobacterium tuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice. Proc. Natl Acad. Sci. USA 95:10797.
31. Cribbs, D. H., Ghochikyan, A., Vasilevko, V. et al. 2003. Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int. Immunol. 15:505.
32. Konig, R., Shen, X., Maroto, R. and Denning, T. L. 2002. The role of CD4 in regulating homeostasis of T helper cells. Immunol. Res. 25:115.
33. Konig, R. 2002. Interactions between MHC molecules and co-receptors of the TCR. Curr. Opin. Immunol. 14:75.
34. Freitas, A. A., Agenes, F. and Coutinho, G. C. 1996. Cellular competition modulates survival and selection of CD8+ T cells. Eur. J. Immunol. 26:2640.