S,S-dimethyl dithiocarbonate: A useful reagent for efficient conversion of aldoximes to nitriles

Synlett

Volumn , Issue 11, 2004, Pages 2019-2021

  Khan, Taukeer Ahmad ^a   Peruncheralathan, Saravanan ^a   Ila, Hiriyakkanavar ^a   Junjappa, Hiriyakkanavar ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

^b BioOrganics & Applied Materials Pvt Ltd   (India)

Author keywords

Dehydration; DMDTC; Nitriles; Oximes

Indexed keywords

ALDEHYDE; ALDOXIME; CARBONIC ACID DERIVATIVE; DITHIOCARBONIC ACID DIMETHYL ESTER; NITRILE; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; SUBSTITUTION REACTION;

EID: 4544303844     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-830878     Document Type: Article

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39. All nitriles were characterized by comparison of their physical and spectroscopic data with reported data.
40. 3N (0.70 mL, 5.0 mmol) in dioxane (15 mL) were heated with stirring at 90°C for 8-11 h (monitored by TLC). Concentration under reduced pressure gave crude product, which was filtered through a short silica gel column using hexane-EtOAc as eluent to give the corresponding nitrile 4.