Total synthesis of xerulinic acid

Angewandte Chemie - International Edition

Volumn 43, Issue 34, 2004, Pages 4523-4526

  Sorg, Achim ^a   Brückner, Reinhard ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

C C coupling; Inhibitors; Lactones; Natural products; Stereoselective synthesis

Indexed keywords

BIOSYNTHESIS; CATALYSIS; CHOLESTEROL; ESTERS; PALLADIUM;

INHIBITORS; XERULINIC ACID;

ORGANIC ACIDS;

CHOLESTEROL SYNTHESIS INHIBITOR; POLYENE; UNCLASSIFIED DRUG; XERULINIC ACID;

ARTICLE; DRUG SYNTHESIS;

EID: 4544296929     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200453729     Document Type: Article

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50. A referee suggested that "the possibility of directly obtaining xerulinic acid from xerulin should be commented on". We are unaware of such a possibility; furthermore, during alternative attempts at the synthesis of xerulinic acid, we prepared both the corresponding alcohol (" xerulinol") and aldehyde ("xerulinal") but could not oxidize either to xerulinic acid: K. Siegel, Ph.D. Thesis, Universität Freiburg, 2000.