The effect of finasteride on the expression of vascular endothelial growth factor and microvessel density: A possible mechanism for decreased prostatic bleeding in treated patients

Journal of Urology

Volumn 169, Issue 1, 2003, Pages 20-23

  Pareek, Gyan ^a,b   Shevchuk, Maria ^a   Armenakas, Noel A ^a   Vasjovic, Ljiljana ^a   Hochberg, David A ^a   Basillote, Jay B ^a   Fracchia, John A ^a  

^a LENOX HILL HOSPITAL   (United States)

^b Department of Surgery ^*  (United States)

Author keywords

Endothelial growth factors; Finasteride; Hematuria; Prostatic hyperplasia

Indexed keywords

FINASTERIDE; VASCULOTROPIN;

AGED; ANGIOGENESIS; ARTICLE; BLOOD VESSEL; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEMATURIA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULATURE; PRIORITY JOURNAL; PROSTATE DISEASE; PROSTATE HYPERTROPHY; TREATMENT OUTCOME;

EID: 0037213171     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)64025-6     Document Type: Article

References (15)

1. Mebust, W. K., Holtgrewe, H. L., Cockett, A. T. K., Peters, P. C. and Writing Committee: Transurethral prostatectomy: Immediate and postoperative complications. A cooperative study of 13 participating institutions evaluating 3,885 patients. J Urol, 141: 243, 1989
2. Foley, S. J. and Bailey, D. M.: Microvessel density in prostatic hyperplasia. BJU Int, 85: 70, 2000
3. Miller, M. I. and Puchner, P. J.: Effects of finasteride on hematuria associated with benign prostatic hyperplasia: Long-term follow-up. Urology, 51: 237, 1998
4. Levine, A. C., Liu, X. H., Greenberg, P. D., Eliashvili, M., Schiff, J. D., Aaronson, S. A. et al: Androgens induce the expression of vascular endothelial growth factor in human fetal prostatic fibroblasts. Endocrinology, 139: 4672, 1998
5. Bettencourt, M.-C., Bauer, J. J., Sesterhenn, I. A., Connelly, R. R. and Moul, J. W.: CD34 immunohistochemical assessment of angiogenesis as a prognostic marker for prostate cancer recurrence after radical prostatectomy. J Urol, 160: 459, 1998
6. Ravindranath, N., Wion, D., Brachet, P. and Djakiew, D.: Epidermal growth factor modulates the expression of vascular endothelial growth factor in the human prostate. J Androl, 22: 432, 2001
7. Hochberg, D. A., Basillote, J. B., Armenakas, N. A., Vasovic, L., Shevchuk, M., Pareek, G. et al: Decreased suburethral prostatic microvessel density in finasteride treated prostates: A possible mechanism for reduced bleeding in benign prostatic hyperplasia. J Urol, 167: 1731, 2002
8. Puchner, P. J. and Miller, M. I.: The effects of finasteride on hematuria associated with benign prostatic hyperplasia: A preliminary report. J Urol, 154: 1779, 1995
9. Foley, S. J., Soloman, L. Z., Wedderburn, A. W., Kashif, K. M., Summerton, D., Basketter, V. et al: A prospective study of the natural history of hematuria associated with benign prostatic hyperplasia and the effect of finasteride. J Urol, 163: 496, 2000
10. Marshall, S. and Narayan, P.: Treatment of prostatic bleeding: Suppression of angiogenesis by androgen deprivation. J Urol, 149: 1553, 1993
11. Franck-Lissbrant, I., Haggestrom, S., Damber, J. E. and Bergh, A.: Testosterone stimulates angiogenesis and vascular regrowth in the ventral prostate in castrated adult rats. Endocrinology, 139: 451, 1998
12. Buttyan, R., Ghafar, M. A. and Shabsigh, A.: The effects of androgen deprivation on the prostate gland: Cell death mediated by vascular regression. Curr Opin Urol, 10: 415, 2000
13. Deering, R. E., Bigler, S. A., Brown, M. and Brawer, M. K.: Microvascularity in benign prostatic hyperplasia. Prostate, 26: 111, 1995
14. Ferrara, N.: Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int, 56: 794, 1999
15. Folkman, J.: Angiogenesis and breast cancer. J Clin Oncol, 12: 441, 1994