Synthesis and phenotypic screening of a guanine-mimetic library

ChemBioChem

Volumn 5, Issue 7, 2004, Pages 1010-1012

  Miller, Stephen C ^a   Mitchison, Timothy J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Chemical biology; Combinatorial chemistry; Fluorescence microscopy; Guanine mimetics; Solid phase synthesis

Indexed keywords

GUANIDINE; QUINAZOLINE DERIVATIVE;

AMINO ACID SYNTHESIS; ARTICLE; BIOACCUMULATION; BIODIVERSITY; BIOMIMETICS; CELL CYCLE; CELL MEMBRANE PERMEABILITY; ENZYME INHIBITION; GENE LIBRARY; HYDROGEN BOND; HYDROPHOBICITY; ISOMERISM; ISOMERIZATION; MOLECULAR INTERACTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCREENING TEST; SOLID STATE;

ACTINS; BIOMIMETICS; CYTOSKELETON; EXOCYTOSIS; GUANINE; HELA CELLS; HUMANS; LIGANDS; MASS SPECTROMETRY; PEPTIDE LIBRARY; PHENOTYPE;

MAMMALIA;

EID: 4544275097     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200400039     Document Type: Article

References (11)

1. D. S. Lawrence, J. Niu, Pharmacol. Ther. 1998, 77, 81.
2. With the exception of cGMP and folate.
3. J. M. Villalgordo, D. Obrecht, A. Chucholowsky, Synlett 1998, 1405.
4. Y. Yu, J. M. Ostresh, R. A. Houghten, J. Org. Chem. 2002, 67, 5831.
5. P. Molina, M. Alajarin, A. Vidal, M. Foces-Foces, F. H. Cano, Tetrahedron 1989, 45, 4263.
6. See also: F. He, B. B. Snider, J. Org. Chem. 1999, 64, 1397.
7. BS-C-1 cells were chosen for their nice, flat cytoskeletal morphology.
8. S. Iwasaki, Med. Res. Rev. 1993, 13, 183.
9. S. C. Miller, T. J. Mitchison, unpublished results.
10. G. Auerbach, A. Herrmann, M. Gutlich, M. Fischer, U. Jacob, A. Bacher, R. Huber, EMBO J. 1997, 16, 7219.
11. E. A. Meyer, R. Brenk, R. K. Castellano, M. Furler, G. Klebe, F. Diederich, ChemBioChem 2002, 3, 250.