Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats

Clinical and Experimental Pharmacology and Physiology

Volumn 30, Issue 5-6, 2003, Pages 399-404

  Chaudhary, Geeta ^a   Sharma, Uma ^a   Jagannathan, Naranamangalam R ^a   Gupta, Yogendra K ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Cerebral ischaemia; Indian herb; Rats; Withania somnifera

Indexed keywords

MALONALDEHYDE; WITHANIA SOMNIFERA EXTRACT;

ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; DIFFUSION WEIGHTED IMAGING; HEMISPHERE; HERBAL MEDICINE; HIGH RISK POPULATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PROPHYLAXIS; RAT; STROKE;

ANIMALS; CEREBROVASCULAR ACCIDENT; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; WITHANIA;

EID: 0038471332     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2003.03849.x     Document Type: Article

References (31)

1. Kaste M. Thrombolysis in ischemic stroke: Present and future. Role of combined therapy. Cerebrovasc. Dis. 2001; 11 (Suppl. 1): 55-9.
2. Martinez-Vila E, Sieira PI. Current status and perspectives of neuroprotection in ischemic stroke treatment. Cerebrovasc. Dis. 2001; 11 (Suppl. 1): 60-70.
3. Gupta YK, Chaudhary G, Sinha K. Enhanced protection by melatonin and meloxicam combination in middle cerebral artery occlusion model of acute ischemic stroke in rat. Can. J. Physiol. Pharmacol. 2002; 80: 210-17.
4. Albers GW. Rationale for early intervention in acute stroke. Am. J. Cardiol. 1997; 80: D4-10.
5. Fisher M, Jonas S, Sacco RL, Jones S. Prophylactic neuroprotection for cerebral ischemia. Stroke 1994; 25: 1075-80.
6. Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study. Phytomedicine 2000; 7: 463-9.
7. Prakash J, Gupta SK, Kochupillai V, Singh N, Gupta YK, Joshi S. Chemopreventive activity of Withania somnifera in experimentally induced fibrosarcoma tumours in Swiss albino mice. Phytother. Res. 2001; 15: 240-4.
8. Gupta YK, Sharma SS, Rai K, Katiyar CK. Reversal of paclitaxel induced neutropenia by Withania sonmifera in mice. Ind. J. Physiol. Pharmacol. 2001; 45: 253-7.
9. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): A review. Altern. Med. Rev. 2000; 5: 334-46.
10. Ziauddin M, Phansalker N, Patki P, Diwanay S, Patwardhan B. Studies on immunomodulatory effects of Ashwagandha. J. Ethnopharmacol. 1996; 50: 69-76.
11. Bhattacharya A, Ghosal S, Bhattacharya SK. Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J. Ethnopharmacol. 2001; 74: 1-6.
12. Koizumi J, Yoshida Y, Nazakawa T, Ooneda G. Experimental studies of ischemic brain edema: A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn. J. Stroke 1986; 8: 1-8.
13. Moran PM, Higgins LS, Cordel B, Moser PC. Age related learning deficits in transgenic mice expressing the 721-amino acid isoform of human beta-amyloid precursor protein. Proc. Natl Acad. Sci. USA 1995; 92: 5341-5.
14. Rogers DC, Campbell CA, Stretton JL, Mackay KB. Correlation between motor impairment and infarct volume after permanent and transient middle artery occlusion in the rat. Stroke 1997; 28: 2060-6.
15. Sinha K, Deogaonkar M, Jagannathan NR, Gupta YK. Effect of melatonin on ischemia-reperfusion injury induced by middle cerebral artery occlusion in rats. Eur. J. Pharmacol. 2001; 428: 185-92.
16. Gupta YK, Sinha K, Chaudhary G, Jagannathan NR. Protective effect of adenosine against neuronal injury induced by middle cerebral artery occlusion in rats as evidenced by diffusion-weighted imaging. Pharmacol. Biochem. Behav. 2002; 72: 569-74.
17. Okhawa H, Ohishim N, Yagi K. Assay of lipid peroxides in animals tissue by thiobarbituraic acid reaction. Anal. Biochem. 1979; 95: 351-8.
18. Gong X, Sucher NJ. Stroke therapy in traditional Chinese medicine (TCM): Prospects for drug discovery and development. Trends Pharmacol. Sci. 1999; 20: 191-6.
19. Wu W, Kuang P, Li Z. ET-1 gene expression of rat brain during ischemia and reperfusion and the protective effect of Radix Salviae Miltiorrhizae. J. Tradit. Chin. Med. 1997; 17: 59-64.
20. Kuang P, Li Z, Zhang F, Tao Y, Liu J, Wu W. Protective effect of Radix Salvaie Miltiorrhizae Composita on cerebral ischemia. J. Tradit. Chin. Med. 1995; 15: 135-40.
21. Ho KK, Wen HL, Lee CM. Tetrmethylpyrazine for treatment of experimentally induced stroke in Mongolian gerbils. Stroke 1989; 20: 96-9.
22. Lim JH, Wen TC, Matsuda S et al. Protection of ischemic hippocampal neurons by ginsenoside rb1, a main ingredient of ginseng root. Neurosci. Res. 1997; 28: 191-200.
23. Sinha K, Chaudhary G, Gupta YK. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci. 2002; 28: 655-65.
24. Belayev L, Alonso OF, Busto R, Zhaow W, Ginsberg MD. Middle cerebral artery occlusion in the rats by intraluminal suture: Neurological and pathological evaluation of an improved model. Stroke 1996; 27: 1616-23.
25. Turgut T, Richard AD, Carano MS et al. A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion. Stroke 1998; 29: 850-8.
26. Yesilada E, Tsuchiya K, Takaishi Y, Kawazoe K. Isolation and characterization of free radical scavenging flavanoids glycosides for the flowers of Spartium junceum by activity guided fractionation. J. Ethnopharmacol. 2000; 73: 471-8.
27. Legos JJ, Erhardt JA, White RF et al. SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia. Brain Res. 2001; 892: 70-7.
28. Siesjo BK. Pathophysiology and treatment of focal cerebral ischemia, part 11: Mechanisms of damage and treatment. J. Neurosurg. 1992; 77: 337-54.
29. Bhattacharya SK, Bhattacharya D, Sairam K, Ghosal S. Effect of Withania somnifera glycowithanolides on a rat model of tardive dyskinesia. Phytomedicine 2002; 9: 167-70.
30. Bhattacharya SK, Stayan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Ind. J. Exp Biol. 1997; 35: 236-9.
31. Dhuley J. Effect of ashwagandha on lipid peroxidation in stress induced animals. J. Ethnopharmacol. 1998; 60: 173-8.