Combined ingestion of protein and carbohydrate improves protein balance during ultra-endurance exercise

American Journal of Physiology - Endocrinology and Metabolism

Volumn 287, Issue 4 50-4, 2004, Pages

  Koopman, René ^a   Pannemans, Daphne L E ^a   Jeukendrup, Asker E ^a,b   Gijsen, Annemie P ^a   Senden, Joan M G ^a   Halliday, David ^a,c   Saris, Wim H M ^a   Van Loon, Luc J C ^a   Wagenmakers, Anton J M ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF THE WEST INDIES   (Jamaica)

Author keywords

Dietary supplements; Protein intake; Protein metabolism

Indexed keywords

CARBOHYDRATE; PROTEIN;

ADULT; ARTICLE; ATHLETE; BLOOD SAMPLING; CARBOHYDRATE INTAKE; COMPARATIVE STUDY; CYCLING; ENDURANCE; EXERCISE; FOOD INTAKE; HUMAN; INTERMETHOD COMPARISON; MALE; METABOLIC REGULATION; NORMAL HUMAN; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN INTAKE; UREA CYCLE;

ADULT; ALGORITHMS; AMINO ACIDS; BEVERAGES; DIET; DIETARY CARBOHYDRATES; DIETARY PROTEINS; EXERCISE; HUMANS; KINETICS; LEUCINE; MALE; OXYGEN CONSUMPTION; PHENYLALANINE; PHYSICAL ENDURANCE; PROTEINS; UREA;

EID: 4544264514     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00543.2003     Document Type: Article

References (40)

1. Ahlborg G, Felig P, Hagenfeldt L, Hendler R, and Wahren J. Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. J Clin Invest 53: 1080-1090, 1974.
2. Biolo G, Tipton KD, Klein S, and Wolfe RR. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Physiol Endocrinol Metab 273: E122-E129, 1997.
3. Borsheim E, Tipton KD, Wolf SE, and Wolfe RR. Essential amino acids and muscle protein recovery from resistance exercise. Am J Physiol Endocrinol Metab 283: E648-E657, 2002.
4. Bowtell JL, Leese GP, Smith K, Watt PW, Nevill A, Rooyackers O, Wagenmakers AJ, and Rennie MJ. Effect of oral glucose on leucine turnover in human subjects at rest and during exercise at two levels of dietary protein. J Physiol 525: 271-281, 2000.
5. Bowtell JL, Leese GP, Smith K, Watt PW, Nevill A, Rooyackers O, Wagenmakers AJ, and Rennie MJ. Modulation of whole body protein metabolism, during and after exercise, by variation of dietary protein. J Appl Physiol 85: 1744-1752, 1998.
6. Carraro F, Hartl WH, Stuart CA, Layman DK, Jahoor F, and Wolfe RR. Whole body and plasma protein synthesis in exercise and recovery in human subjects. Am J Physiol Endocrinol Metab 258: E821-E831, 1990.
7. Carraro F, Kimbrough TD, and Wolfe RR. Urea kinetics in humans at two levels of exercise intensity. J Appl Physiol 75: 1180-1185, 1993.
8. Carraro F, Stuart CA, Hartl WH, Rosenblatt J, and Wolfe RR. Effect of exercise and recovery on muscle protein synthesis in human subjects. Am J Physiol Endocrinol Metab 259: E470-E476, 1990.
9. Cathcart EP. The influence of muscle work on protein metabolism. Physiol Rev 5: 225-243, 1925.
10. 13C]tyrosine in the postabsorptive state. Metabolism 31: 999-1005, 1982.
11. 2 production during exercise before and after endurance training. J Appl Physiol 75: 70-75, 1993.
12. Collin-Vidal C, Cayol M, Obled C, Ziegler F, Bommelaer G, and Beaufrere B. Leucine kinetics are different during feeding with whole protein or oligopeptides. Am J Physiol Endocrinol Metab 267: E907-E914, 1994.
13. Decombaz J, Reinhardt P, Anantharaman K, von Glutz G, and Poortmans JR. Biochemical changes in a 100-km run: free amino acids, urea, and creatinine. Eur J Appl Physiol 41: 61-72, 1979.
14. Fick A and Wislecenus J. On the origin of muscular power. Philos Mag 31: 485-503, 1866.
15. Fryburg DA, Jahn LA, Hill SA, Oliveras DM, and Barrett EJ. Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest 96: 1722-1729, 1995.
16. 14C]carbonate. Clin Sci 35: 553-564, 1968.
17. Kuipers H, Verstappen FT, Keizer HA, Geurten P, and van Kranenburg G. Variability of aerobic performance in the laboratory and its physiologic correlates. Int J Sports Med 6: 197-201, 1985.
18. Lemon PW and Mullin JP. Effect of initial muscle glycogen levels on protein catabolism during exercise. J Appl Physiol 48: 624-629, 1980.
19. Matthews DE and Downey RS. Measurement of urea kinetics in humans: a validation of stable isotope tracer methods. Am J Physiol Endocrinol Metab 246: E519-E527, 1984.
20. 13C]leucine. Am J Physiol Endocrinol Metab 238: E473-E479, 1980.
21. Munro HN and Fleck A. Analysis of tissues and body fluids for nitrogenous constituents. In: Mammalian Protein Metabolism, edited by Munro HN. New York: Academic, 1969, p. 423-525.
22. Pacy PJ, Garrow JS, Ford GC, Merritt H, and Halliday D. Influence of amino acid administration on whole-body leucine kinetics and resting metabolic rate in postabsorptive normal subjects. Clin Sci (Lond) 75: 225-231, 1988.
23. Phillips SM, Atkinson SA, Tarnopolsky MA, and MacDougall JD. Gender differences in leucine kinetics and nitrogen balance in endurance athletes. J Appl Physiol 75: 2134-2141, 1993.
24. Rasmussen BB, Tipton KD, Miller SL, Wolf SE, and Wolfe RR. An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. J Appl Physiol 88: 386-392, 2000.
25. Rennie MJ, Edwards RH, Krywawych S, Davies CT, Halliday D, Waterlow JC, and Millward DJ. Effect of exercise on protein turnover in man. Clin Sci (Lond) 61: 627-639, 1981.
26. Stein TP, Hoyt RW, Toole MO, Leskiw MJ, Schluter MD, Wolfe RR, and Killer WD. Protein and energy metabolism during prolonged exercise in trained athletes, Int J Sports Med 10: 311-316, 1989.
27. 5]phenylalanine model. Am J Physiol Endocrinol Metab 256: E631-E639, 1989.
28. Tipton KD, Borsheim E, Wolf SE, Sanford AP, and Wolfe RR. Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion. Am J Phvsiol Endocrinol Metab 284: E76-E89, 2003.
29. Tipton KD, Ferrando AA, Phillips SM, Doyle D Jr, and Wolfe RR. Postexercise net protein synthesis in human muscle from orally administered amino acids. Am J Physiol Endocrinol Metab 276: E628-E634, 1999.
30. Tipton KD, Ferrando AA, Williams BD, and Wolfe RR. Muscle protein metabolism in female swimmers after a combination of resistance and endurance exercise. J Appl Physiol 81: 2034-2038, 1996.
31. Van Acker BA, Hulsewe KW, Wagenmakers AJ, Soeters PB, and von Meyenfeldt MF. Glutamine appearance rate in plasma is not increased after gastrointestinal surgery in humans. J Nutr 130: 1566-1571, 2000.
32. Van Hall G, MacLean DA, Saltin B, and Wagenmakers AJ. Mechanisms of activation of muscle branched-chain α-keto acid dehydrogenase during exercise in man. J Physiol 494: 899-905, 1996.
33. Von Liebig J. Animal Chemistry or Organic Chemistry in Its Application to Physiology. London: Taylor and Walton, 1842.
34. Wagenmakers AJ, Beckers EJ, Brouns F, Kuipers H, Soeters PB, van der Vusse GJ, and Saris WH. Carbohydrate supplementation, glycogen depletion, and amino acid metabolism during exercise. Am J Physiol Endocrinol Metab 260: E883-E890, 1991.
35. Wagenmakers AJ, Brookes JH, Coakley JH, Reilly T, and Edwards RH. Exercise-induced activation of the branched-chain 2-oxo acid dehydrogenase in human muscle. Eur J Appl Physiol 59: 159-167, 1989.
36. 2 background enrichment during exercise: diet-related differences between Europe and America. J Appl Physiol 74: 2353-2357, 1993.
37. Waterlow JC. The mysteries of nitrogen balance. Nutr Res Rev 12: 25-54, 1999.
38. Wolfe RR. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. New York: Wiley-Liss, 1992.
39. Wolfe RR, Goodenough RD, Wolfe MH, Royle GT, and Nadel ER. Isotopic analysis of leucine and urea metabolism in exercising humans. J Appl Physiol 52: 458-466, 1982.
40. Wolfe RR, Wolfe MH, Nadel ER, and Shaw JH. Isotopic determination of amino acid-urea interactions in exercise in humans. J Appl Physiol 56: 221-229, 1984.