Nongerminomatous germ cell tumor of the pineal gland causing gonadotropin-independent precocious puberty in a child with 47, XYY karyotype: A clinical and radiographic case review

Endocrinologist

Volumn 14, Issue 5, 2004, Pages 261-264

  Khan, Asjad ^a   Price, Donald ^a   Castro Magaña, Mariano ^a   Angulo, Moris ^a   Cañas, J Atilio ^a,b  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

^b NEMOURS CHILDREN S CLINIC   (United States)

Author keywords

Embryonal carcinoma; Germ cell tumor; Klinefelter syndrome; Precocious puberty; XYY male

Indexed keywords

ALPHA FETOPROTEIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; FOLLITROPIN; LUTEINIZING HORMONE; TESTOSTERONE;

CASE REPORT; CLINICAL EXAMINATION; COMPUTER ASSISTED TOMOGRAPHY; FOLLITROPIN BLOOD LEVEL; GERM CELL TUMOR; HUMAN; KLINEFELTER SYNDROME; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PINEAL BODY TUMOR; PRECOCIOUS PUBERTY; PRESCHOOL CHILD; REVIEW; TESTOSTERONE BLOOD LEVEL;

EID: 4544253885     PISSN: 10512144     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ten.0000139000.64137.60     Document Type: Review

References (40)

1. Sandberg AA KG, Ishihara T, Hauschka TS. An XYY human male. Lancet. 1961;2:971-972.
2. Robinson DO, Jacobs PA. The origin of the extra Y chromosome in males with a 47,XYY karyotype. Hum Mol Genet. 1999;8:2205-2209.
3. Fryns JP, Kleczkowska A, Kubien E, et al. XYY syndrome and other Y chromosome polysomies. Mental status and psychosocial functioning. Genet Couns. 1995;6:197-206.
4. Nichols CR, Heerema NA, Palmer C, et al. Klinefelter's syndrome associated with mediastinal germ cell neoplasms. J Clin Oncol. 1987; 5:1290-1294.
5. Derenoncourt AN, Castro-Magana M, Jones KL. Mediastinal teratoma and precocious puberty in a boy with mosaic Klinefelter syndrome. Am J Med Genet. 1995;55:38-42.
6. Ganslandt O, Buchfelder M, Grabenbauer GG. Primary spinal germinoma in a patient with concomitant Klinefelter's syndrome. Br J Neurosurg. 2000;14:252-255.
7. Finlay J, Boyce H, Licktenbaum K, et al. Intensified multiagent chemotherapy including cisplatin for newly diagnosed CNS germ cell tumors GCT: results of the Second International CNS Germ Cell Tumor Study. J Neurooncol. 2000;2(suppl):53-54.
8. Brodeur GM, Howarth CB, Pratt CB, et al. Malignant germ cell tumors in 57 children and adolescents. Cancer. 1981;48:1890-1898.
9. Rescorla FJ, Breitfeld PP. Pediatric germ cell tumors. Curr Probl Cancer. 1999;23:257-303.
10. Balinsky BI FB. An Introduction to Embryology, 4th ed. Philadelphia: WB Saunders Co; 1975.
11. Sano K, Matsutani M, Seto T. So-called intracranial germ cell tumours: personal experiences and a theory of their pathogenesis. Neurol Res. 1989;11:118-126.
12. Chaganti RS, Rodriguez E, Mathew S. Origin of adult male mediastinal germ-cell tumours. Lancet. 1994;343:1130-1132.
13. Houldsworth J. Genetics and biology of male germ cell tumors. Chest Surg Clin North Am. 2002;12:629-643.
14. Sherr CJ. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 1998;12:2984-2991.
15. Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 1995;9:1149-1163.
16. Robertson KD, Jones PA. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol. 1998;18:6457-6473.
17. Iwato M, Tachibana O, Tohma Y, et al. Molecular analysis for p53 and mdm2 in intracranial germ cell tumors. Acta Neuropathol (Berl). 2000; 99:21-25.
18. Iwato M, Tachibana O, Tohma Y, et al. Alterations of the INK4a/ARF locus in human intracranial germ cell tumors. Cancer Res. 2000;60: 2113-2115.
19. Jennings MT, Gelman R, Hochberg F. Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg. 1985;63:155-167.
20. Horowitz MB, Hall WA. Central nervous system germinomas. A review. Arch Neurol. 1991;48:652-657.
21. Allen JC, Nisselbaum J, Epstein F, et al. Alphafetoprotein and human chorionic gonadotropin determination in cerebrospinal fluid. An aid to the diagnosis and management of intracranial germ-cell tumors. J Neurosurg. 1979;51:368-374.
22. Labdenne P, Heikinheimo M. Clinical use of tumor markers in childhood malignancies. Ann Med. 2002;34:316-323.
23. Liang L, Korogi Y, Sugahara T, et al. MRI of intracranial germ-cell tumours. Neuroradiology. 2002;44:382-388.
24. James HE, Edwards MS. Systemic staging of supratentorial extra-axial brain tumors in children. Craniopharyngiomas, atypical teratoma and teratoid tumors of the suprasellar region (germinomas), and intracranial teratomas. Cancer. 1985;56(suppl):1800-1803.
25. Herrmann HD, Westphal M, Winkler K, et al. Treatment of nongerminomatous germ-cell tumors of the pineal region. Neurosurgery. 1994; 34:524-529; discussion 529.
26. Calaminus G, Bamberg M, Baranzelli MC, et al. Intracranial germ cell tumors: a comprehensive update of the European data. Neuropediatrics. 1994;25:26-32.
27. Balmaceda C, Modak S, Finlay J. Central nervous system germ cell tumors. Semin Oncol. 1998;25:243-250.
28. Knappe UJ, Bentele K, Horstmann M, et al. Treatment and long-term outcome of pineal nongerminomatous germ cell tumors. Pediatr Neurosurg. 1998;28:241-245.
29. Sawamura Y, Ikeda JL, Tada M, et al. Salvage therapy for recurrent germinomas in the central nervous system. Br J Neurosurg. 1999;13: 376-381.
30. Weiner HL, Finlay JL. Surgery in the management of primary intracranial germ cell tumors. Childs Nerv Syst. 1999;15:770-773.
31. Matsutani M, Sano K, Takakura K, et al. Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg. 1997;86:446-455.
32. Weiner HL, Lichtenbaum RA, Wisoff JH, et al. Delayed surgical resection of central nervous system germ cell tumors. Neurosurgery. 2002;50:727-733; discussion 733-724.
33. Williams PC, Henner WD, Roman-Goldstein S, et al. Toxicity and efficacy of carboplatin and etoposide in conjunction with disruption of the blood-brain tumor barrier in the treatment of intracranial neoplasms. Neurosurgery 1995;37:17-27 (discussion 27-28).
34. Rutgers JL, Scully RE. Pathology of the testis in intersex syndromes. Semin Diagn Pathol. 1987;4:275-291.
35. Manuel M, Katayama PK, Jones HW Jr. The age of occurrence of gonadal tumors in intersex patients with a Y chromosome. Am J Obstet Gynecol. 1976;124:293-300.
36. Midro AT, Wojtukiewicz M, Bielawiec M, et al. XYY syndrome and acute myeloblastic leukemia. Cancer Genet Cytogenet. 1987;24:363-365.
37. Perez de Oteyza J, Sureda A, Ferro T, et al. Acute lymphoblastic leukemia in an XYY male. Cancer Genet Cytogenet. 1990;49:225-227.
38. Taub JW, Ravindranath Y, Mohamed AN, et al. Acute lymphoblastic leukemia in a 46,XY/47,XYY mosaic male: clonal origin of leukemia in the XY-bearing stem-cell line. Am J Dis Child. 1993;147:1254-1255.
39. Leschek EW, Doppman JL, Pass HI, et al. Localization by venous sampling of occult chorionic gonadotropin-secreting tumor in a boy with mosaic Klinefelter's syndrome and precocious puberty. J Clin Endocrinol Metab. 1996;81:3825-3828.
40. Castro-Magana M, Angulo M, Collipp PJ, et al. Paradoxical association of central precocious puberty and hypergonadotropic hypogonadism in 3 patients with Klinefelter, Down, and Turner syndrome. J Pediatr Endocrinol Metab. 1985;1:61-69.