메뉴 건너뛰기




Volumn 2, Issue 5, 2004, Pages 633-636

A new era in atherosclerosis drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ANTIINFLAMMATORY AGENT; ATORVASTATIN; AUTACOID; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CARDIOVASCULAR AGENT; CD40 ANTIGEN; CHOLESTEROL; FIBRINOGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; PLACEBO; PRAVASTATIN; VASCULAR CELL ADHESION MOLECULE 1;

EID: 4544253571     PISSN: 14779072     EISSN: None     Source Type: Journal    
DOI: 10.1586/14779072.2.5.633     Document Type: Editorial
Times cited : (4)

References (26)
  • 1
    • 0021524498 scopus 로고
    • How LDL receptors influence cholesterol and atherosclerosis
    • Brown M, Goldstein JL. How LDL receptors influence cholesterol and atherosclerosis. Sci. Am. 251, 58-66 (1984).
    • (1984) Sci. Am. , vol.251 , pp. 58-66
    • Brown, M.1    Goldstein, J.L.2
  • 2
    • 0029756177 scopus 로고    scopus 로고
    • Lipids, risk factors and ischemic heart disease
    • Castelli WP. Lipids, risk factors and ischemic heart disease. Atherosclerosis 124(Suppl.), S1-S9 (1996).
    • (1996) Atherosclerosis , vol.124 , Issue.SUPPL. 1
    • Castelli, W.P.1
  • 3
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - An inflammatory disease
    • Ross R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340, 115-126 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 4
    • 0020972414 scopus 로고
    • Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
    • Brown MS, Goldstein JL. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Ann. Rev. Biochem. 52, 223-261 (1983).
    • (1983) Ann. Rev. Biochem. , vol.52 , pp. 223-261
    • Brown, M.S.1    Goldstein, J.L.2
  • 5
    • 0036852744 scopus 로고    scopus 로고
    • The macrophage foam cell as a target for therapeutic intervention
    • Li AC, Glass CK. The macrophage foam cell as a target for therapeutic intervention. Nature Med. 8, 1235-1242 (2002).
    • (2002) Nature Med. , vol.8 , pp. 1235-1242
    • Li, A.C.1    Glass, C.K.2
  • 6
    • 0000061171 scopus 로고
    • Modification of low-density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low-density lipoprotein phospholipids
    • Steinbrechner UP, Parthasarathy S, Leake DS et al. Modification of low-density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low-density lipoprotein phospholipids. Proc. Natl Acad. Sci. USA 81, 3883-3887 (1984).
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 3883-3887
    • Steinbrechner, U.P.1    Parthasarathy, S.2    Leake, D.S.3
  • 7
    • 0037022910 scopus 로고    scopus 로고
    • Inflammation and atherosclerosis
    • Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 105, 1135-1143 (2002).
    • (2002) Circulation , vol.105 , pp. 1135-1143
    • Libby, P.1    Ridker, P.M.2    Maseri, A.3
  • 8
    • 0036852699 scopus 로고    scopus 로고
    • Stabilization of atherosclerotic plaques: New mechanisms and clinical targets
    • Libby P, Aikawa M. Stabilization of atherosclerotic plaques: new mechanisms and clinical targets. Nature Med. 8, 1257-1262 (2002).
    • (2002) Nature Med. , vol.8 , pp. 1257-1262
    • Libby, P.1    Aikawa, M.2
  • 9
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomized placebo-controlled trial
    • Heart Protection Study Collaboration Group
    • Heart Protection Study Collaboration Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomized placebo-controlled trial. Lancet 360, 7-22 (2002).
    • (2002) Lancet , vol.360 , pp. 7-22
  • 10
    • 1842765431 scopus 로고    scopus 로고
    • Intensive statin therapy: A sea change in cardiovascular prevention
    • Topol EJ. Intensive statin therapy: a sea change in cardiovascular prevention. N. Engl. J. Med. 350, 1562-1564 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1562-1564
    • Topol, E.J.1
  • 11
    • 0031768396 scopus 로고    scopus 로고
    • Cholesterol and plasma lipid modifying patents
    • Suckling KE. Cholesterol and plasma lipid modifying patents. Exp. Opin. Ther. Patents 8(11), 1415-1424 (1998).
    • (1998) Exp. Opin. Ther. Patents , vol.8 , Issue.11 , pp. 1415-1424
    • Suckling, K.E.1
  • 12
    • 0034036648 scopus 로고    scopus 로고
    • Modified LDL - Trigger of atherosclerosis and inflammation in the arterial intima
    • Pentikäinen MO, Öörni K, Ala-Korpela M et al. Modified LDL - trigger of atherosclerosis and inflammation in the arterial intima. J. Intern. Med. 247, 359-370 (2000).
    • (2000) J. Intern. Med. , vol.247 , pp. 359-370
    • Pentikäinen, M.O.1    Öörni, K.2    Ala-Korpela, M.3
  • 13
    • 10744225301 scopus 로고    scopus 로고
    • Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: A randomized controlled trial
    • Nissen SE, Tuzcu EM, Schoenhagen P et al. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. J. Am. Med. Assoc. 291, 1071-1080 (2004).
    • (2004) J. Am. Med. Assoc. , vol.291 , pp. 1071-1080
    • Nissen, S.E.1    Tuzcu, E.M.2    Schoenhagen, P.3
  • 14
    • 11144355354 scopus 로고    scopus 로고
    • Comparison of intensive and moderate lipid lowering with statins following acute coronary syndrome
    • Cannon CP, Braunwald E, McCabe CH et al. Comparison of intensive and moderate lipid lowering with statins following acute coronary syndrome. N. Engl. J. Med 350, 1495-1504 (2004).
    • (2004) N. Engl. J. Med , vol.350 , pp. 1495-1504
    • Cannon, C.P.1    Braunwald, E.2    McCabe, C.H.3
  • 15
    • 0036382099 scopus 로고    scopus 로고
    • Clinical significance of pleiotropic effects of statins: Lipid reduction and beyond
    • Auer J, Berent R, Weber T, Eber B. Clinical significance of pleiotropic effects of statins: lipid reduction and beyond. Curr. Med. Chem. 9, 1831-1850 (2002).
    • (2002) Curr. Med. Chem. , vol.9 , pp. 1831-1850
    • Auer, J.1    Berent, R.2    Weber, T.3    Eber, B.4
  • 16
    • 0035010184 scopus 로고    scopus 로고
    • A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    • Cybulsky MI, Iiyama Y, Li H et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J. Clin. Invest. 107, 1255-1262 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 1255-1262
    • Cybulsky, M.I.1    Iiyama, Y.2    Li, H.3
  • 17
    • 0033380747 scopus 로고    scopus 로고
    • Soluble vascular cell adhesion molecule (VCAM)-1 as a potential marker of atherosclerosis
    • Peter K, Weirich U, Nordt TK et al. Soluble vascular cell adhesion molecule (VCAM)-1 as a potential marker of atherosclerosis. Thromb. Haemost. 82(Suppl.), 38-43 (1999).
    • (1999) Thromb. Haemost. , vol.82 , Issue.SUPPL. , pp. 38-43
    • Peter, K.1    Weirich, U.2    Nordt, T.K.3
  • 18
    • 0025954705 scopus 로고
    • Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions
    • Ylä-Herttuala S, Lipton BA, Rosenfeld ME et al. Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc. Natl Acad. Sci. USA 88, 5252-5256 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5252-5256
    • Ylä-Herttuala, S.1    Lipton, B.A.2    Rosenfeld, M.E.3
  • 19
    • 0025281588 scopus 로고
    • Minimally modified low-density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells
    • Cushing SD, Berliner JA, Valente AJ et al. Minimally modified low-density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc. Natl Acad. Sci. USA 87, 5134-5138 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5134-5138
    • Cushing, S.D.1    Berliner, J.A.2    Valente, A.J.3
  • 20
    • 0032134003 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low-density lipoprotein receptor-deficient mice
    • Gu L, Okada Y, Clinton SK et al. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Mol. Cell 2, 275-281 (1998).
    • (1998) Mol. Cell , vol.2 , pp. 275-281
    • Gu, L.1    Okada, Y.2    Clinton, S.K.3
  • 21
    • 0037469177 scopus 로고    scopus 로고
    • Clinical application of C-reactive protein for cardiovascular disease detection and prevention
    • Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107, 363-369 (2003).
    • (2003) Circulation , vol.107 , pp. 363-369
    • Ridker, P.M.1
  • 22
    • 0035963529 scopus 로고    scopus 로고
    • Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    • Ridker PM, Rifai N, Clearfield M et al. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N. Engl. J. Med. 344, 1959-1965 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1959-1965
    • Ridker, P.M.1    Rifai, N.2    Clearfield, M.3
  • 23
    • 1842587885 scopus 로고    scopus 로고
    • C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
    • Danesh J, Wheeler JG, Hirschfield GM et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N. Engl. J. Med. 350, 1387-1397 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1387-1397
    • Danesh, J.1    Wheeler, J.G.2    Hirschfield, G.M.3
  • 24
    • 1242340472 scopus 로고    scopus 로고
    • Fibrinogen - Marker or mediator of vascular disease?
    • Reinhart WH. Fibrinogen - marker or mediator of vascular disease? Vasc. Med. 8, 211-216 (2003).
    • (2003) Vasc. Med. , vol.8 , pp. 211-216
    • Reinhart, W.H.1
  • 25
    • 0037308314 scopus 로고    scopus 로고
    • Hyperlipidemias and serum cytokines in patients with coronary artery disease
    • Mizia-Stec K, Zahorska-Markiewicz B, Mandecki T et al. Hyperlipidemias and serum cytokines in patients with coronary artery disease. Acta Cardiol. 58, 9-15 (2003).
    • (2003) Acta Cardiol. , vol.58 , pp. 9-15
    • Mizia-Stec, K.1    Zahorska-Markiewicz, B.2    Mandecki, T.3
  • 26
    • 3142624781 scopus 로고    scopus 로고
    • Inflammatory and oxidative markers in atherosclerosis: Relationship to outcome
    • Shishehbor MH, Hazen SL. Inflammatory and oxidative markers in atherosclerosis: relationship to outcome. Curr. Atheroscler. Rep. 6, 243-250 (2004).
    • (2004) Curr. Atheroscler. Rep. , vol.6 , pp. 243-250
    • Shishehbor, M.H.1    Hazen, S.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.