Tissue Doppler imaging for the evaluation of patients with hypertrophic cardiomyopathy

Current Opinion in Cardiology

Volumn 19, Issue 5, 2004, Pages 430-436

  Rajiv, Chandrasekharan ^a   Vinereanu, Dragos ^b   Fraser, Alan G ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Hypertrophic cardiomyopathy; Strain; Strain rate; Tissue Doppler echocardiography; Velocity

Indexed keywords

LOSARTAN; SIMVASTATIN;

ATHLETE; CLINICAL TRIAL; DIAGNOSTIC ACCURACY; DIASTOLE; DOPPLER ECHOCARDIOGRAPHY; GENE MUTATION; GENETICS; HEART LEFT VENTRICLE; HEART MUSCLE RELAXATION; HEART VENTRICLE CONTRACTION; HEART VENTRICLE FUNCTION; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; MUSCLE FIBRIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SYSTOLE; VELOCITY;

EID: 4544252840     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.hco.0000131537.78399.52     Document Type: Review

References (44)

1. Klues HG, Schiffers A, Maron BJ: Phenotypic spectrum and patterns of left ventricular hypertrophy in hypertrophic cardiomyopathy. Morphologic observations and significance as assessed by 2D echocardiography in 600 patients. J Am Coll Cardiol 1995, 26:1699-1708.
2. Crilley JG, Boehm EA, Blair E, et al.: Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterised by impaired energy metabolism irrespective of the degree of hypertrophy. J Am Coll Cardiol 2003, 41:1776-1782. Provides evidence supporting a new concept for the pathogenesis of HCM, which in turn implies that even precise diagnosis by echocardiography may not be able to discriminate between different genetic causes of hypertrophy.
3. Richard P, Charron P, Carrier L, et al.: Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy. EUROGENE Heart Failure Project. Circulation 2003, 107:2227-2232. In a systematic population study, 25 of 197 cases of HCM were sporadic, and 60 novel mutations were identified. Some families had more than 1 mutation.
4. Charron P, Forissier JF, Amara ME, et al.: Accuracy of European diagnostic criteria for familial hypertrophic cardiomyopathy in agenotyped population. Int J Cardiol 2003, 90:33-38. In a genotyped group of 109 patients, combinations of echocardiographic criteria using conventional methods could achieve only a sensitivity of 76% and a specificity of 90% for recognizing HCM.
5. Palka P, Lange A, Fleming AD, et al.: Differences in myocardial velocity gradient measured throughout the cardiac cycle in patients with hypertrophic cardiomyopathy, athletes and patients with left ventricular hypertrophy due to hypertension. J Am Coll Cardiol 1997, 30:760-768.
6. Fraser AG, Payne N, Mädler CF, et al.: Feasibility and reproducibility of off-line tissue Doppler measurement of regional myocardial function during dobutamine stress echocardiography. Eur J Echocardiogr 2003, 4:43-53. A detailed analysis of the reproducibility of off-line measurements of regional myocardial velocities at rest and during dobutamine stress.
7. Vinereanu D, Florescu N, Sculthorpe N, et al.: Differentiation between pathologic and physiologic left ventricular hypertrophy by tissue Doppler assessment of long-axis function in patients with hypertrophic cardiomyopathy or systemic hypertension and in athletes. Am J Cardiol 2001, 88:53-58.
8. Cardim N, Castela S, Cordeiro R, et al.: Tissue Doppler imaging assessment of long axis left ventricular function in hypertrophic cardiomyopathy. Rev Port Cardiol 2002, 21:953-985. Detailed report of abnormalities of long-axis left ventricular function as assessed by tissue Doppler in patients with HCM, compared with controls.
9. Tabata T, Oki T, Yamada H, et al.: Subendocardial motion in hypertrophic cardiomyopathy: assessment from long and short-axis views by pulsed tissue Doppler imaging. J Am Soc Echocardiogr 2000, 13:108-115.
10. Vinereanu D, Nicolaides E, Tweddel AC, et al.: Subclinical left ventricular dysfunction in asymptomatic patients with type 2 diabetes mellitus, related to serum lipids and glycated haemoglobin. Clin Science 2003, 105:591-599. Tissue Doppler study reporting reduced systolic and diastolic long-axis velocities in patients with uncomplicated diabetes, compared with age-matched controls, but increased radial function in the same patients.
11. Vogel M, Schmidt R, Kristiansen S, et al.: Validation of myocardial acceleration during isovolumic contraction as a novel noninvasive index of right ventricular contractility. Comparison with ventricular pressure-volume relations in an animal model. Circulation 2002, 105:1693-1699. First demonstration that isovolumic acceleration correlates with +dp/dt and that it is very insensitive to altered preload or afterload, but influenced by contractility. Still needs to be tested as a diagnostic tool for HCM.
12. Mishiro Y, Oki T, Yamada H, et al.: Use of angiotensin II stress pulsed tissue Doppler imaging to evaluate regional left ventricular contractility in patients with hypertrophic cardiomyopathy. J Am Soc Echocardiogr 2000, 13:1065-1073.
13. Cardim N, Torres D, Morais H, et al.: Tissue Doppler imaging in hypertrophic cardiomyopathy: impact of intraventricular obstruction on longitudinal left ventricular function. Rev Port Cardiol 2002, 21:271-297. A study that shows similarity of tissue Doppler parameters in HCM patients with and without obstruction.
14. Severino S, Caso P, Galderisi M, et al.: Use of pulsed Doppler tissue imaging to assess regional left ventricular diastolic dysfunction in hypertrophic cardiomyopathy. Am J Cardiol 1998, 82:1394-1398.
15. Lombardi R, Betocchi S, Losi MA, et al.: Myocardial collagen turnover in hypertrophic cardiomyopathy. Circulation 2003, 108:1455-1460. Unusual study that demonstrates correlations between serum markers of collagen metabolism and the severity of global diastolic dysfunction in 36 patients with HCM.
16. Frommelt PC, Pelech AN, Frommelt MA: Diastolic dysfunction in an unusual case of cardiomyopathy in a child: insights from Doppler and Doppler tissue imaging analysis. J Am Soc Echocardiogr 2003, 16:176-181. An interesting case report of a child with HCM with delayed ventricular relaxation giving rise to a mitral Doppler 'L' wave, an annular 'La' wave on tissue Doppler, and a corresponding reduction in LV pressure in diastasis.
17. Kato T, Noda A, Izawa H, et al.: Myocardial velocity gradient as a non-invasively determined index of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 2003, 42:278-285. A cutoff value of peak negative MVG in early diastole was a useful diagnostic marker for HCM.
18. 123I- β-Methyl lodophenyl Pentadecanoic acid myocardial scintigraphy. Clin Cardiol 2004, 27:33-39. In HCM, reduced early diastolic MVG correlates with abnormal myocardial fatty acid metabolism detected by myocardial scintigraphy.
19. Shimizu Y, Uematsu M, Shimizu H, et al.: Peak negative myocardial velocity gradient in early diastole as a noninvasive indicator of left ventricular diastolic function: comparison with transmitral flow velocity indices. J Am Coll Cardiol 1998, 32:1418-1425.
20. Oki T, Mishiro Y, Yamada H, et al.: Detection of left ventricular regional relaxation abnormalities and asynchrony in patients with hypertrophic cardiomy opathy with the use of tissue Doppler imaging. Am Heart J 2000, 139:497-502.
21. Nagueh SF, Lakkis NM, Middleton KJ, et al.: Doppler estimation of left ventricular filling pressures in patients with hypertrophic cardiomyopathy. Circulation 1999, 99:254-261.
22. Nishimura RA, Appleton CP, Redfield MM, et al.: Non-invasive Doppler echocardiographic evaluation of left ventricular filling pressures in patients with cardiomyopathies: a simultaneous Doppler echocardiographic and cardiac catheterization study. J Am Coll Cardiol 1996, 28:1226-1233.
23. McMahon CJ, Nagueh SF, Pignatelli RH, et al.: Characterisation of left ventricular diastolic function by tissue Doppler imaging and clinical status in children with hypertrophic cardiomyopathy. Circulation 2004:109. First systematic study of tissue Doppler in children with HCM, and first study demonstrating that new echocardiographic indices that include tissue Doppler measurements predict major clinical events and risk of death.
24. Matsumura Y, Elliott PM, Virdee MS, et al.: Left ventricular diastolic function assessed using Doppler tissue imaging in patients with hypertrophic cardiomyopathy: relation to symptoms and exercise capacity. Heart 2002, 87:247-251. Reports an inverse correlation in patients with HCM between LV filling pressure estimated by echocardiography (from ratio of mitral to mitral annular early diastolic velocities) and peak oxygen consumption, and a direct correlation with NYHA class.
25. Ito T, Suwa M, Imai M, et al.: Assessment of regional left ventricular filling dynamics using color kinesis in patients with hypertrophic cardiomyopathy. J Am Soc Echocardiogr 2004, 17:146-151. Confirmation using a different echocardiographic modality-colour kinesis-that patients with HCM have regional asynchrony of LV filling.
26. Urheim S, Edvardsen T, Torp H, et al.: Myocardial strain by Doppler echocardiography. Validation of a new method to quantify regional myocardial function. Circulation 2000, 102:1158-1164.
27. Yang H, Sun JP, Lever HM, et al.: Use of strain imaging in detecting segmental dysfunction in patients with hypertrophic cardiomyopathy. J Am Soc Echocardiogr 2003, 16:233-239. Interesting confirmation in preselected populations that regional myocardial strain is depressed in hypertrophied segments in patients with HCM, but this observation needs reassessment in genetically defined populations and clinical studies in unselected patients.
28. Weidemann F, Mertens L, Gewillig M, Sutherland GR: Quantification of localised abnormal deformation in assymetrical nonobstructive hypertrophic cardiomyopathy: a velocity, strain rate, and strain Doppler myocardial imaging study. Pediatr Cardiol 2001, 22:534-537.
29. Cardim N, Longo S, Ferreira T, et al.: Tissue Doppler imaging assessment of long axis left ventricular function in hypertensive patients with concentric left ventricular hypertrophy: differential diagnosis with hypertrophic cardiomyopathy. Rev Port Cardiol 2002, 21:709-740. Provides detailed analysis of various systolic and diastolic tissue Doppler parameters in patients with LVH due to hypertension and HCM.
30. Derumeaux G, Douillet R, Troniou A, et al.: Distinguishing between physiologic hypertrophy in athletes and primary hypertrophic cardiomyopathies. Importance of tissue color Doppler. Arch Mal Coeur Vaiss 1999, 92:201-210.
31. Cardim N, Oliveira AG, Longo S, et al.: Tissue Doppler imaging: regional myocardial function in hypertrophic cardiomyopathy and in athlete's heart. J Am Soc Echocardiogr 2003, 16:223-232. Confirmation of their previous Portuguese publication that tissue Doppler of LV long-axis function can differentiate HCM from athlete's heart.
32. D'Andrea A, Caso P, Severino S, et al.: Different involvement of right ventricular myocardial function in either physiologic or pathologic left ventricular hypertrophy: a Doppler tissue study. J Am Soc Echocardiogr 2003, 16:154-161. Confirms that HCM affects right as well as left ventricular function and demonstrates that this can provide diagnostic support in difficult cases.
33. Whyte GP, George K, Sharma S, et al.: The upper limit of physiological cardiac hypertrophy in elite male and female athletes: the British experience. Eur J Appl Physiol 2004, 16:154-161. Useful reassessment of 'normal' measurements of LV wall thickness and cavity size in different categories of athletes.
34. Sitges M, Shiola T, Lever HM, et al.: Comparison of left ventricular diastolic function in obstructive hypertrophic cardiomyopathy in patients undergoing percutaneous septal alcohol ablation versus surgical myotomy/myectomy. Am J Cardiol 2003, (e published ahead of print). Tissue Doppler can demonstrate improved diastolic function in patients with obstructive HCM following septal reduction by a percutaneous or surgical approach.
35. Rovner A, Smith R, Greenberg NL, et al.: Improvement in diastolic intraventricular pressure gradients in patients with HOCM after ethanol septal reduction. Am J Physiol 2003, 285:H2492-H2499. Intraventricular diastolic pressure gradients measured invasively, and LV inflow propagation velocities measured noninvasively (both indicating improved diastolic suction) increased after septal reduction in patients with HOCM.
36. Park TH, Lakkis NM, Middleton KJ, et al.: Acute effect of nonsurgical septal reduction therapy on regional left ventricular asynchrony in patients with hypertrophic obstructive cardiomyopathy. Circulation 2002, 106:412-415. This study shows that nonsurgical septal reduction therapy has a favorable effect on regional LV asynchrony.
37. Abraham TP, Nishimura RA, Holmes DR, et al.: Strain rate imaging for assessment of regional myocardial function: results from a clinical model of septal ablation. Circulation 2002, 105:1403-1409. This study highlights the superiority of strain rate over tissue velocities for quantifying subtle changes of function in small regions of myocardium-in this case, in patients with HOCM after alcohol septal reduction. Limitations of strain rate imaging are also discussed.
38. Lim DS, Lutucuta S, Bachireddy P, et al.: Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy. Circulation 2001, 103:789-791.
39. Patel R, Nagueh SF, Tsybouleva N, et al.: Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic-cardiomyopathy. Circulation 2001, 104:317-324.
40. Tsybouleva N, Zhang L, Chen S, et al.: Atdosterone, through novel signalling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. Circulation 2004, 109:1284-1291. A basic science report implicating aldosterone as a major link between sarcomeric mutations and the cardiac phenotype in a transgenic mouse model of HCM.
41. Nagueh SF, Kopelen HA, Lim DS, et al.: Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation 2000, 102:1346-1350.
42. Nagueh SF, Bachinski LL, Meyer D, et al.: Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy. Circulation 2001, 104:128-130.
43. Ho CY, Sweitzer NK, McDonough B, et al.: Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy. Circulation 2002, 105:2992-2997. important observation that mean longitudinal myocardial velocities during early diastole are lower in patients with an HCM genotype irrespective of whether or not they have LVH, compared with normal controls.
44. Nagueh SF, McFalls J, Meyer D, et al.: Tissue Doppler imaging predicts the development of hypertrophic cardiomyopathy in subjects with subclinical disease. Circulation 2003, 108:395-398. Confirmation from serial observations in a small group of patients that reduced myocardial velocities at presentation in patients who had mutations for HCM but did not have left ventricular hypertrophy, thereafter predicted the development of phenotypic left ventricular hypertrophy and a further reduction of myocardial velocities.