Tissue doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy

Circulation

Volumn 102, Issue 12, 2000, Pages 1346-1350

  Nagueh, Sherif F ^a,b   Kopelen, Helen A ^a   Lim, Do Sun ^a   Zoghbi, William A ^a   Quiñones, Miguel A ^a   Roberts, Robert ^a   Marian, Ali J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

Cardiomyopathy; Echocardiography; Genetics; Hypertrophy; Imaging

Indexed keywords

GLUTAMIC ACID; MYOSIN HEAVY CHAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOPPLER ECHOCARDIOGRAPHY; HEART CONTRACTION; HEART MUSCLE RELAXATION; HYPERTROPHIC CARDIOMYOPATHY; M MODE ECHOCARDIOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RABBIT; TRANSGENIC ANIMAL; TWO DIMENSIONAL ECHOCARDIOGRAPHY;

EID: 0034687163     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.12.1346     Document Type: Article

References (13)

1. Molecular genetics of inherited cardiomyopathies
2. Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy
3. Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy
4. Prevalence of hypertrophic cardiomyopathy and limitations of screening methods
5. Role of candidate modifier genes on the phenotypic expression of hypertrophy in patients with hypertrophic cardiomyopathy
6. Prognostic significance of beta-myosin heavy chain mutations is reflective of their hypertrophic expressivity in patients with hypertrophic cardiomyopathy
7. Expression of a mutant (Arg92Gln) human cardiac troponin T, known to cause hypertrophic cardiomyopathy, impairs adult cardiac myocytes contractility
8. Identification of a contractile deficit in adult cardiac myocytes expressing hypertrophic cardiomyopathy-associated mutant troponin T proteins
9. An α-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes
10. Pathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy
11. A transgenic rabbit model for human hypertrophic cardiomyopathy
12. Doppler estimation of left ventricular filling pressures in patients with hypertrophic cardiomyopathy
13. Use of pulsed Doppler tissue imaging to assess regional left ventricular diastolic dysfunction in hypertrophic cardiomyopathy