Kinetic mechanism of protease inhibition by α 1-antitrypsin

Biochemical and Biophysical Research Communications

Volumn 323, Issue 2, 2004, Pages 409-415

  Kang, Un Beom ^a,b   Baek, Je Hyun ^a,b   Ryu, Seung Hyun ^a,b   Kim, Joon ^b   Yu, Myeong Hee ^a   Lee, Cheolju ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

Author keywords

1 Antitrypsin; Acyl intermediate; Rapid quench study; Rate determining step; Salt bridge; Serpin; Stopped flow experiment

Indexed keywords

ALPHA 1 ANTITRYPSIN; ELASTASE; SERINE PROTEINASE INHIBITOR;

ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; DRUG MECHANISM; FLUORESCENCE RESONANCE ENERGY TRANSFER; INHIBITION KINETICS; MICHAELIS CONSTANT; PRIORITY JOURNAL; REGULATORY MECHANISM;

ALPHA 1-ANTITRYPSIN; AMINO ACID SUBSTITUTION; BINDING SITES; ENZYME ACTIVATION; ENZYME INHIBITORS; FLOW INJECTION ANALYSIS; KINETICS; PANCREATIC ELASTASE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4544240242     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.08.105     Document Type: Article

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