A simple protocol for the modular assembly of "millipede" artificial enzymes

Angewandte Chemie - International Edition

Volumn 43, Issue 10, 2004, Pages 1225-1228

  Motherwell, William B ^a   Atkinson, Catherine E ^a   Aliev, Abil E ^a   Wong, Stephanie Y F ^b   Warrington, Brian H ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Catalysis; Enzyme; Esters; Hydrolysis; Mimics; Polymers

Indexed keywords

CATALYSIS; CATALYSTS; MOLECULAR STRUCTURE; POLYMERS;

MOLECULAR STRANDS; SUBSTRATE RECEPTORS; TRANSITION STATE;

ENZYMES;

ENZYME; POLYMER; RECEPTOR;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL BINDING; CHEMICAL BOND; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONFORMATION; ENZYME ACTIVATION; GEOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; HYDROLYSIS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PROTEIN ENGINEERING; PROTEIN FUNCTION;

BINDING SITES; CATALYSIS; DIPEPTIDES; ENZYMES; MODELS, MOLECULAR; POLYMERS;

EID: 4544229372     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200352370     Document Type: Article

References (32)

1. a) J. D. Stevenson, N. R. Thomas, Nat. Prod. Rep. 2000, 17, 535;
2. b) W. B. Motherwell, M. J. Bingham, Y. Six, Tetrahedron 2001, 57, 4663.
3. a) R. Breslow, S. D. Dong, Chem. Rev. 1998, 98, 1997;
4. b) L. J. Twyman, A. S. H. King, I. K. Martin, Chem. Soc. Rev. 2002, 31, 69;
5. c) G. Wulff, Chem. Rev. 2002, 102, 1;
6. d) J. H. Suh, Synlett 2001, 9, 1343.
7. P. A. Brady, J. K. M. Sanders, Chem. Soc. Rev. 1997, 26, 327.
8. a) A. Tramontano, K. D. Janda, R. A. Lerner, Science 1986, 234, 1566;
9. b) S. J. Pollack, J. W. Jacobs, P. G. Schultz, Science 1986, 234, 1570.
10. a) F. Tanaka, Chem. Rev. 2002, 102, 4885;
11. b) J. L. Raymond, Top. Curr. Chem. 1999, 200, 59.
12. a) V. J. DeRose, Chem. Biol. 2002, 9, 961;
13. b) C. Frauendorf, A. Jäschke, Angew. Chem. 1998, 110, 1449; Angew. Chem. Int. Ed. 1998, 37, 1378.
14. b) C. Frauendorf, A. Jäschke, Angew. Chem. 1998, 110, 1449; Angew. Chem. Int. Ed. 1998, 37, 1378.
15. a) K.-E. Jaeger, T. Eggert, A. Eipper, M. T. Reetz, Appl. Microbiol. Biotechnol. 2001, 55, 519;
16. b) M. T. Reetz, M. Hermes, M. H. Becker, Appl. Microbiol. Biotechnol. 2001, 55, 531;
17. c) H. Y. Tao, V. W. Cornish, Curr. Opin. Chem. Biol. 2002, 6, 858.
18. a) F. M. Menger, A. V. Eliseev, V. A. Migulin, J. Org. Chem. 1995, 60, 6666;
19. b) F. M. Menger, C. A. West, J. Ding, Chem. Commun. 1997, 633;
20. c) F. M. Menger, J. Ding, V. Barragan, J. Org. Chem. 1998, 63, 7578.
21. I. M. Klotz in Enzyme Mechanisms (Eds.: M. I. Page, A. Williams), Royal Society of Chemistry, London, 1987, pp. 14-34.
22. D. H. Wu, A. D. Chen, C. S. Johnson, J. Magn. Reson. Ser. A 1995, 115, 260.
23. a) L. Fielding, Tetrahedron 2000, 56, 6151;
24. b) M. F. Lin, D. A. Jayawickrama, R. A. Rose, J. A. Delviscio, C. K. Larive, Anal. Chim. Acta 1995, 307, 449;
25. c) A. Gafni, Y. Cohen, J. Org. Chem. 1997, 62, 120.
26. C. E. Atkinson, A. E. Aliev, W. B. Motherwell, Chem. Eur. J. 2003, 9, 1714.
27. C. G. Suresh, J. Ramaswamy, M. Vilayan, Acta Crystallogr. Sect. B 1986, 42, 473.
28. a) D. R. Carcanague, F. Diederich, Angew. Chem., 1990, 102, 836; Angew. Chem. Int. Ed. Engl. 1990, 29, 769;
29. a) D. R. Carcanague, F. Diederich, Angew. Chem., 1990, 102, 836; Angew. Chem. Int. Ed. Engl. 1990, 29, 769;
30. b) B. R. Peterson, P. Wallimann, D. R. Carcanague, F. Diederich, Tetrahedron 1995, 51, 401.
31. A. R. Ferscht, Structure and mechanism in protein science. A guide to enzyme catalysis and protein folding, W. H. Freeman, New York, 1999.
32. N. Tanaka, K. Nakagawa, H. Iwasaki, K. Hosoya, K. Kimata, T. Araki, D. G. Patterson, Jr., J. Chromatogr. A 1997, 781, 139.