Distinct regions of the mouse cyclin A1 gene, Ccna1, confer male germ-cell specific expression and enhancer function

Biology of Reproduction

Volumn 71, Issue 4, 2004, Pages 1340-1347

  Lele, Karen M ^a   Wolgemuth, Debra J ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

Cyclin; Gene regulation; Kinases; Meiosis; Spermatogenesis; Testis

Indexed keywords

BETA GALACTOSIDASE; CYCLIN A; CYCLIN A1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL DIVISION; CELL SPECIFICITY; CELL TYPE; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENHANCER REGION; GENE CONSTRUCT; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GERM CELL; MALE; MEIOSIS; MOUSE; NONHUMAN; PACHYTENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REPORTER GENE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SOMATIC CELL; SPERMATOCYTE; TESTIS; TISSUE SPECIFICITY; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; BETA-GALACTOSIDASE; CELL CYCLE; CYCLIN A; GENE EXPRESSION REGULATION; GERM CELLS; MALE; MEIOSIS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; SEQUENCE ALIGNMENT; SPERMATOGENESIS; TESTIS; TRANSCRIPTION, GENETIC;

ANIMALIA; EUKARYOTA; MAMMALIA; MUS MUSCULUS;

EID: 4544223871     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.104.030387     Document Type: Article

References (43)

1. Sassone-Corsi P. Unique chromatin remodeling and transcriptional regulation in spermatogenesis. Science 2002; 296:2176-2178.
2. Eddy EM. Male germ cell gene expression. Recent Prog Horm Res 2002; 57:103-128.
3. Wolgemuth DJ, Rhee K, Wu S, Ravnik SE. Genetic control of mitosis, meiosis and cellular differentiation during mammalian spermatogenesis. Reprod Fertil Dev 1995; 7:669-683.
4. Beumer TL, Roepers-Gajadien HL, Gademan LS, Rutgers DH, de Rooij DG. P21(Cip1/WAF1) expression in the mouse testis before and after X irradiation. Mol Reprod Dev 1997; 47:240-247.
5. Sherr CJ. Mammalian G1 cyclins. Cell 1993; 73:1059-1065.
6. Pines J. Cyclins and cyclin-dependent kinases: a biochemical view. Biochem J 1995; 308:697-711.
7. Wolgemuth DJ, Laurion E, Lele KM. Regulation of the mitotic and meiotic cell cycles in the male germ line. Recent Prog Horm Res 2002; 57:75-101.
8. Sweeney C, Murphy M, Kubelka M, Ravnik SE, Hawkins CF, Wolgemuth DJ, Carrington M. A distinct cyclin A is expressed in germ cells in the mouse. Development 1996; 122:53-64.
9. Ravnik SE, Wolgemuth DJ. Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage. Dev Biol 1999; 207:408-418.
10. Liu D, Matzuk MM, Sung WK, Guo Q, Wang P, Wolgemuth DJ. Cyclin A1 is required for meiosis in the male mouse. Nat Genet 1998; 20:377-380.
11. Murphy M, Stinnakre MG, Senamaud-Beaufort C, Winston NJ, Sweeney C, Kubelka M, Carrington M, Brechot C, Sobczak-Thepot J. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. [published erratum appears in Nat Genet 1999 23: 481]. Nat Genet 1997; 15:83-86.
12. Murphy M, Stinnakre MG, Senamaud-Beaufort C, Winston NJ, Sweeney C, Kubelka M, Carrington M, Brechot C, Sobczak-Thepot J. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. [published erratum appears in Nat Genet 1999 23: 481]. Nat Genet 1997; 15:83-86.
13. Yang R, Morosetti R, Koeffler HP. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res 1997; 57:913-920.
14. Kramer A, Hochhaus A, Saussele S, Reichert A, Willer A, Hehlmann R. Cyclin A1 is predominantly expressed in hematological malignancies with myeloid differentiation. Leukemia 1998; 12:893-898.
15. Yang R, Muller C, Huynh V, Fung YK, Yee AS, Koeffler HP. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol Cell Biol 1999b; 19:2400-2407.
16. Liao C, Li SQ, Wang X, Muhlrad S, Bjartell A, Wolgemuth DJ. Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors. Int J Cancer 2004; 108:654-664.
17. Muller C, Yang R, Beck-von-Peccoz L, Idos G, Verbeek W, Koeffler HP. Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene. J Biol Chem 1999; 274:11220-11228.
18. Muller C, Yang R, Idos G, Tidow N, Diederichs S, Koch OM, Verbeek W, Bender TP, Koeffler HP. c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression. Blood 1999; 94: 4255-4262.
19. Muller C, Readhead C, Diederichs S, Idos G, Yang R, Tidow N, Serve H, Berdel WE, Koeffler HP. Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent. Mol Cell Biol 2000; 20:3316-3329.
20. Muller-Tidow C, Readhead C, Cohen AH, Asotra K, Idos G, Diederichs S, Cauvet T, Yang R, Berdel WE, Serve H, Koeffler HP. Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice. Int J Mol Med 2003; 11:311-315.
21. Behringer RR, Crotty DA, Tennyson VM, Brinster RL, Palmiter RD, Wolgemuth DJ. Sequences 5′ of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development. Development 1993; 117:823-833.
22. Packer AI, Crotty DA, Elwell VA, Wolgemuth DJ. Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element. Development 1998; 125:1991-1998.
23. Heinemeyer T, Wingender E, Reuter I, Hermjakob H, Kel AE, Kel OV, Ignatieva EV, Ananko EA, Podkolodnaya OA, Kolpakov FA, Podkolodny NL, Kolchanov NA. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res 1998; 26:362-367.
24. Latham KE, Litvin J, Orth JM, Patel B, Mettus R, Reddy EP. Temporal patterns of A-myb and B-myb gene expression during testis development. Oncogene 1996; 13:1161-1168.
25. Goodson ML, Park-Sarge OK, Sarge KD. Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activities. Mol Cell Biol 1995; 15:5288-5293.
26. Persengiev SP, Raval PJ, Rabinovitch S, Millette CF, Kilpatrick DL. Transcription factor Sp1 is expressed by three different developmentally regulated messenger ribonucleic acids in mouse spermatogenic cells. Endocrinology 1996; 137:638-646.
27. Yang R, Nakamaki T, Lubbert M, Said J, Sakashita A, Freyaldenhoven BS, Spira S, Huynh V, Muller C, Koeffler HP. Cyclin A1 expression in leukemia and normal hematopoietic cells. Blood 1999; 93:2067-2074.
28. Ravnik SE, Wolgemuth DJ. The developmentally restricted pattern of expression in the male germ line of a murine cyclin A, cyclin A2, suggests roles in both mitotic and meiotic cell cycles. Dev Biol 1996; 173:69-78.
29. Zwicker J, Lucibello FC, Wolfraim LA, Gross C, Truss M, Engeland K, Muller R. Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J 1995; 14:4514-4522.
30. Lange-zu Dohna C, Brandeis M, Berr F, Mossner J, Engeland K. A CDE/CHR tandem element regulates cell cycle-dependent repression of cyclin B2 transcription. FEBS Lett 2000; 484:77-81.
31. Fontijn RD, Goud B, Echard A, Jollivet F, van Marle J, Pannekoek H, Horrevoets; AJ. The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis. Mol Cell Biol 2001; 21:2944-2955.
32. Uchiumi T, Longo DL, Ferris DK. Cell cycle regulation of the human polo-like kinase (PLK) promoter. J Biol Chem 1997; 272:9166-9174.
33. Fajas L, Le Cam L, Polanowska J, Fabbrizio E, Servant N, Philips A, Camac G, Sardet C. A CDE/CHR-like element mediates repression of transcription of the mouse RB2 (p130) gene. FEBS Lett 2000; 471: 29-33.
34. Otaki M, Hatano M, Kobayashi K, Ogasawara T, Kuriyama T, Tokuhisa T. Cell cycle-dependent regulation of TIAP/m-survivin expression. Biochim Biophys Acta 2000; 1493:188-194.
35. Tanaka M, Ueda A, Kanamori H, Ideguchi H, Yang J, Kitajima S, Ishigatsubo Y. Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1. J Biol Chem 2002; 277:10719-10726.
36. Sugarman JL, Schonthal AH, Glass CK. Identification of a cell-type-specific and E2F-independent mechanism for repression of cdc2 transcription. Mol Cell Biol 1995; 15:3282-3290.
37. Badie C, Itzhaki JE, Sullivan MJ, Carpenter AJ, Porter AC. Repression of CDK1 and other genes with CDE and CHR promoter elements during DNA damage-induced G(2)/M arrest in human cells. Mol Cell Biol 2000; 20:2358-2366.
38. Wasner M, Haugwitz U, Reinhard W, Tschop K, Spiesbach K, Lorenz J, Mossner J, Engeland K. Three CCAAT-boxes and a single cell cycle genes homology region (CHR) are the major regulating sites for transcription from the human cyclin B2 promoter. Gene 2003; 312:225-237.
39. Haugwitz U, Wasner M, Wiedmann M, Spiesbach K, Rother K, Mossner J, Engeland K. A single cell cycle genes homology region (CHR) controls cell cycle-dependent transcription of the cdc25C phosphatase gene and is able to cooperate with E2F or Sp1/3 sites. Nucleic Acids Res 2002; 30:1967-1976.
40. Liu N, Lucibello FC, Korner K, Wolfraim LA, Zwicker J, Muller R. CDF-1, a novel E2F-unrelated factor, interacts with cell cycle-regulated repressor elements in multiple promoters. Nucleic Acids Res 1997; 25:4915-4920.
41. Philips A, Chambeyron S, Lamb N, Vie A, Blanchard JM. CHF: a novel factor binding to cyclin A CHR corepressor element. Oncogene 1999; 18:6222-6232.
42. Kishore R, Spyridopoulos I, Luedemann C, Losordo DW. Functionally novel tumor necrosis factor-alpha-modulated CHR-binding protein mediates cyclin A transcriptional repression in vascular endothelial cells. Circ Res 2002; 91:307-314.
43. Toscani A, Mettus RV, Coupland R, Simpkins H, Litvin J, Orth J, Hatton KS, Reddy EP. Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Nature 1997; 386:713-717.