Total synthesis of (±)-actinophyllic acid

Journal of the American Chemical Society

Volumn 130, Issue 24, 2008, Pages 7568-7569

  Martin, Connor L ^a   Overman, Larry E ^a   Rohde, Jason M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b IRONWOOD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINOPHYLLIC ACID; INDOLE ALKALOID; KETONE; MALONIC ACID DERIVATIVE; 2 N BUTYLMALONATE; 2-N-BUTYLMALONATE;

ARTICLE; BROMINATION; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; OXIDATION; REACTION ANALYSIS; ROOM TEMPERATURE; STRUCTURE ANALYSIS; CHEMISTRY; SYNTHESIS; TECHNIQUE;

INDOLE ALKALOIDS; MALONATES; METHODS;

EID: 45249090324     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja803158y     Document Type: Article

References (18)

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11. 2 was employed as the oxidant.
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16. The constitution and relative configuration of the α epimer was confirmed by single-crystal X-ray analysis.
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18. 1 for natural 1 was obtained; see the Supporting Information for details. Unfortunately, a sample of natural actinophyllic acid is no longer available for direct comparison.