The HLA-G 14bp gene polymorphism and decidual HLA-G 14bp gene expression in pre-eclamptic and normal pregnancies

Journal of Reproductive Immunology

Volumn 78, Issue 2, 2008, Pages 158-165

  Iversen, Ann Charlotte ^a   Nguyen, Olav Toai Duc ^a   Tømmerdal, Linda Føll ^a   Eide, Irina Poliakova ^a,b   Landsem, Veslemøy Malm ^a   Acar, Nuray ^c   Myhre, Ronny ^a   Klungland, Helge ^a   Austgulen, Rigmor ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Decidua; Gene polymorphism; HLA G; Pre eclampsia; Pregnancy

Indexed keywords

HLA G ANTIGEN; MESSENGER RNA;

3' UNTRANSLATED REGION; ADULT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DECIDUA; DNA POLYMORPHISM; FEMALE; FETUS BLOOD; FETUS GROWTH; GENE; GENE EXPRESSION; GENOTYPE; HLA G GENE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MATERNAL BLOOD; PREECLAMPSIA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; ALLELES; DECIDUA; FEMALE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; POLYMORPHISM, GENETIC; PRE-ECLAMPSIA; PREGNANCY;

EID: 45249084263     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2008.03.001     Document Type: Article

References (39)

1. Benirschke K., Kaufmann P., and Baergen R.N. Decidua. In: Benirschke K., et al. (Ed). Pathology of the Human Placenta (2006), Springer Science &Business Media Inc., New York, NY 217-225
2. Bermingham J., Jenkins D., McCarthy T., and O'Brien M. Genetic analysis of insulin-like growth factor II and HLA-G in pre-eclampsia. Biochem. Soc. Trans. 28 (2000) 215-219
3. Blaschitz A., Lenfant F., Mallet V., Hartmann M., Bensussan A., Geraghty D.E., Le Bouteiller P., and Dohr G. Endothelial cells in chorionic fetal vessels of first trimester placenta express HLA-G. Eur. J. Immunol. 27 (1997) 3380-3388
4. Carreiras M., Montagnani S., and Layrisse Z. Preeclampsia: a multifactorial disease resulting from the interaction of the feto-maternal HLA genotype and HCMV infection. Am. J. Reprod. Immunol. 48 (2002) 176-183
5. Colbern G.T., Chiang M.H., and Main E.K. Expression of the nonclassic histocompatibility antigen HLA-G by preeclamptic placenta. Am. J. Obstet. Gynecol. 170 (1994) 1244-1250
6. Eide I.P., Isaksen C.V., Salvesen K.A., Langaas M., Gunther C.C., Iversen A.C., and Austgulen R. Fetal growth restriction is associated with reduced FasL expression by decidual cells. J. Reprod. Immunol. 74 (2007) 7-14
7. Fujii T., Ishitani A., and Geraghty D.E. A soluble form of the HLA-G antigen is encoded by a messenger ribonucleic acid containing intron 4. J. Immunol. 153 (1994) 5516-5524
8. Gifford R.W., August P.A., Cunningham G., Green L.A., Lindheimer M.D., McNellis D., Roberts J.M., Sibai B.M., and Taler S.J. Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy. Am. J. Obstet. Gynecol. 183 (2000) S1-S22
9. Goldman-Wohl D.S., Ariel I., Greenfield C., Hochner-Celnikier D., Cross J., Fisher S., and Yagel S. Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia. Mol. Hum. Reprod. 6 (2000) 88-95
10. Hara N., Fujii T., Yamashita T., Kozuma S., Okai T., and Taketani Y. Altered expression of human leukocyte antigen G (HLA-G) on extravillous trophoblasts in preeclampsia: immunohistological demonstration with anti-HLA-G specific antibody '87G' and anti-cytokeratin antibody 'CAM5.2'. Am. J. Reprod. Immunol. 36 (1996) 349-358
11. Hiby S.E., King A., Sharkey A., and Loke Y.W. Molecular studies of trophoblast HLA-G: polymorphism, isoforms, imprinting and expression in preimplantation embryo. Tissue Antigens 53 (1999) 1-13
12. Houlihan J.M., Biro P.A., Harper H.M., Jenkinson H.J., and Holmes C.H. The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G. J. Immunol. 154 (1995) 5665-5674
13. Humphrey K.E., Harrison G.A., Cooper D.W., Wilton A.N., Brennecke S.P., and Trudinger B.J. HLA-G deletion polymorphism and pre-eclampsia/eclampsia. Br. J. Obstet. Gynaecol. 102 (1995) 707-710
14. Hviid T.V. HLA-G genotype is associated with fetoplacental growth. Hum. Immunol. 65 (2004) 586-593
15. Hviid T.V., Hylenius S., Hoegh A.M., Kruse C., and Christiansen O.B. HLA-G polymorphisms in couples with recurrent spontaneous abortions. Tissue Antigens 60 (2002) 122-132
16. Hviid T.V., Hylenius S., Rorbye C., and Nielsen L.G. HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels. Immunogenetics 55 (2003) 63-79
17. Hviid T.V., Moller C., Sorensen S., and Morling N. Co-dominant expression of the HLA-G gene and various forms of alternatively spliced HLA-G mRNA in human first trimester trophoblast. Hum. Immunol. 59 (1998) 87-98
18. Hylenius S., Andersen A.M., Melbye M., and Hviid T.V. Association between HLA-G genotype and risk of pre-eclampsia: a case-control study using family triads. Mol. Hum. Reprod. 10 (2004) 237-246
19. Ishitani A., and Geraghty D.E. Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 3947-3951
20. Kaufmann P., Black S., and Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol. Reprod. 69 (2003) 1-7
21. Kirszenbaum M., Moreau P., Gluckman E., Dausset J., and Carosella E. An alternatively spliced form of HLA-G mRNA in human trophoblasts and evidence for the presence of HLA-G transcript in adult lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 4209-4213
22. Kovats S., Main E.K., Librach C., Stubblebine M., Fisher S.J., and DeMars R. A class I antigen, HLA-G, expressed in human trophoblasts. Science 248 (1990) 220-223
23. Le Friec G., Gros F., Sebti Y., Guilloux V., Pangault C., Fauchet R., and Amiot L. Capacity of myeloid and plasmacytoid dendritic cells especially at mature stage to express and secrete HLA-G molecules. J. Leukoc. Biol. 76 (2004) 1125-1133
24. Le Rond S., Le Maoult J., Creput C., Menier C., Deschamps M., Le Friec G., Amiot L., Durrbach A., Dausset J., Carosella E.D., and Rouas-Freiss N. Alloreactive CD4+ and CD8+ T cells express the immunotolerant HLA-G molecule in mixed lymphocyte reactions: in vivo implications in transplanted patients. Eur. J. Immunol. 34 (2004) 649-660
25. Lim K.H., Zhou Y., Janatpour M., McMaster M., Bass K., Chun S.H., and Fisher S.J. Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia. Am. J. Pathol. 151 (1997) 1809-1818
26. Lin A., Yan W.H., Dai M.Z., Chen X.J., Li B.L., Chen B.G., and Fan L.A. Maternal human leukocyte antigen-G polymorphism is not associated with pre-eclampsia in a Chinese Han population. Tissue Antigens 68 (2006) 311-316
27. Marsal K., Persson P.H., Larsen T., Lilja H., Selbing A., and Sultan B. Intrauterine growth curves based on ultrasonically estimated foetal weights. Acta Paediatr. 85 (1996) 843-848
28. Moreau P., Carosella E., Teyssier M., Prost S., Gluckman E., Dausset J., and Kirszenbaum M. Soluble HLA-G molecule. An alternatively spliced HLA-G mRNA form candidate to encode it in peripheral blood mononuclear cells and human trophoblasts. Hum. Immunol. 43 (1995) 231-236
29. Moscoso J., Serrano-Vela J.I., Pacheco R., and Arnaiz-Villena A. HLA-G, -E and -F: allelism, function and evolution. Transpl. Immunol. 17 (2006) 61-64
30. Naicker T., Khedun S.M., Moodley J., and Pijnenborg R. Quantitative analysis of trophoblast invasion in preeclampsia. Acta Obstet. Gynecol. Scand. 82 (2003) 722-729
31. O'Brien M., McCarthy T., Jenkins D., Paul P., Dausset J., Carosella E.D., and Moreau P. Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease. Cell. Mol. Life Sci. 58 (2001) 1943-1949
32. Paul P., Cabestre F.A., Ibrahim E.C., Lefebvre S., Khalil-Daher I., Vazeux G., Quiles R.M., Bermond F., Dausset J., and Carosella E.D. Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells. Hum. Immunol. 61 (2000) 1138-1149
33. Rebmann V., Busemann A., Lindemann M., and Grosse-Wilde H. Detection of HLA-G5 secreting cells. Hum. Immunol. 64 (2003) 1017-1024
34. Rizzo R., Hviid T.V., Stignani M., Balboni A., Grappa M.T., Melchiorri L., and Baricordi O.R. The HLA-G genotype is associated with IL-10 levels in activated PBMCs. Immunogenetics 57 (2005) 172-181
35. Rouas-Freiss N., Goncalves R.M., Menier C., Dausset J., and Carosella E.D. Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 11520-11525
36. Rousseau P., Le Discorde M., Mouillot G., Marcou C., Carosella E.D., and Moreau P. The 14 bp deletion-insertion polymorphism in the 3′ UT region of the HLA-G gene influences HLA-G mRNA stability. Hum. Immunol. 64 (2003) 1005-1010
37. Sibai B., Dekker G., and Kupferminc M. Pre-eclampsia. Lancet 365 (2005) 785-799
38. Staff A.C., Ranheim T., Khoury J., and Henriksen T. Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia. Am. J. Obstet. Gynecol. 180 (1999) 587-592
39. Vianna P., Dalmaz C.A., Veit T.D., Tedoldi C., Roisenberg I., and Chies J.A. Immunogenetics of pregnancy: role of a 14-bp deletion in the maternal HLA-G gene in primiparous pre-eclamptic Brazilian women. Hum. Immunol. 68 (2007) 668-674