Polyadenylation and degradation of mRNA in mammalian mitochondria: A missing link?

Biochemical Society Transactions

Volumn 36, Issue 3, 2008, Pages 517-519

  Bobrowicz, Agnieszka J ^a   Lightowlers, Robert N ^a   Chrzanowska Lightowlers, Zofia ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Mitochondrion; mRNA stability; Polyadenylation; Polynucleotide phosphorylase (PNPase)

Indexed keywords

MESSENGER RNA; MITOCHONDRIAL DNA;

DNA TRANSCRIPTION; ENZYME ACTIVITY; GENE EXPRESSION; MITOCHONDRION; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; RNA PROCESSING;

MAMMALIA;

EID: 45249083439     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360517     Document Type: Review

References (15)

1. Ojala, D., Montoya, J. and Attardi, G. (1981) tRNA punctuation model of RNA processing in human mitochondria. Nature 290, 470-474
2. Rossmanith, W. and Karwan, R.M. (1998) Characterization of human mitochondrial RNase P: novel aspects in tRNA processing. Biochem. Biophys. Res. Commun. 247, 234-241
3. Nagaike, T., Suzuki, T., Tomari, Y., Takemoto-Hori, C., Negayama, F., Watanabe, K. and Ueda, T. (2001) Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases. J. Biol. Chem. 276, 40041-40049
4. Gagliardi, D., Stepien, P.P., Temperley, R.J., Lightowlers, R.N. and Chrzanowska-Lightowlers, Z.M. (2004) Messenger RNA stability in mitochondria: different means to an end. Trends Genet. 20, 260-267
5. Piwowarski, J., Grzechnik, P., Dziembowski, A., Dmochowska, A., Minczuk, M. and Stepien, P.P. (2003) Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria. J. Mol. Biol. 329, 853-857
6. Tomecki, R., Dmochowska, A., Gewartowski, K., Dziembowski, A. and Stepien, P.P. (2004) Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase. Nucleic Acids Res. 32, 6001-6014
7. Nagaike, T., Suzuki, T., Katoh, T. and Ueda, T. (2005) Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase. J. Biol. Chem. 280, 19721-19727
8. Malecki, M., Jedrzejczak, R., Stepien, P.P. and Golik, P. (2007) In vitro reconstitution and characterization of the yeast mitochondrial degradosome complex unravels tight functional interdependence. J. Mol. Biol. 372, 23-36
9. Carpousis, A.J. (2007) The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E. Annu. Rev. Microbiol. 61, 71-87
10. Chen, H.W., Koehler, C.M. and Teitell, M.A. (2007) Human polynucleotide phosphorylase: location matters. Trends Cell Biol. 17, 600-608
11. Temperley, R.J., Seneca, S.H., Tonska, K., Bartnik, E., Bindoff, L.A., Lightowlers, R.N. and Chrzanowska-Lightowlers, Z.M. (2003) Investigation of a pathogenic mtDNA microdeletion reveals a translation-dependent deadenylation decay pathway in human mitochondria. Hum. Mol. Genet. 12, 2341-2348
12. Chrzanowska-Lightowlers, Z.M., Temperley, R.J., Smith, P.M., Seneca, S.H. and Lightowlers, R.N. (2004) Functional polypeptides can be synthesized from human mitochondrial transcripts lacking termination codons. Biochem. J. 377, 725-731
13. Slomovic, S., Laufer, D., Geiger, D. and Schuster, G. (2005) Polyadenylation and degradation of human mitochondrial RNA: the prokaryotic past leaves its mark. Mol. Cell. Biol. 25, 6427-6435
14. Slomovic, S., Portnoy, V., Yehudai-Resheff, S., Bronshtein, E. and Schuster, G. (2007) Polynucleotide phosphorylase and the archaeal exosome as poly(A)-polymerases. Biochim. Biophys. Acta 1779, 247-255
15. Slomovic, S. and Schuster, G. (2008) Stable PNPase RNAi silencing: its effect on the processing and adenylation of human mitochondrial RNA. RNA 14, 310-323