Lower visceral and subcutaneous but higher intermuscular adipose tissue depots in patients with growth hormone and insulin-like growth factor I excess due to acromegaly

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 6, 2008, Pages 2334-2343

  Freda, Pamela U ^a   Shen, Wei ^b   Heymsfield, Steven B ^b,d   Reyes Vidal, Carlos M ^a   Geer, Eliza B ^c   Bruce, Jeffrey N ^a   Gallagher, Dympna ^b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c MOUNT SINAI MEDICAL CENTER   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GROWTH HORMONE; INSULIN; SOMATOMEDIN C;

ACROMEGALY; ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

EID: 45149127238     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-2780     Document Type: Article

References (72)

1. Ho KK, O'Sullivan AJ, Hoffman DM 1996 Metabolic actions of growth hormone in man. Endocr J 43(Suppl):S57-S63
2. Russell-Jones DL, Weissberger AJ 1996 The role of growth hormone in the regulation of body composition in the adult. Growth Regul 6:247-252
3. Bengtsson BA, Brummer RJ, Bosaeus I 1990 Growth hormone and body composition. Horm Res 33(Suppl 4):19-24
4. Clemmons DR 2004 The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity. J Clin Invest 113:25-27
5. Clemmons DR 2002 Roles of insulin-like growth factor-I and growth hormone in mediating insulin resistance in acromegaly. Pituitary 5:181-183
6. O'Sullivan AJ, Kelly JJ, Hoffman DM, Freund J, Ho KK 1994 Body composition and energy expenditure in acromegaly. J Clin Endocrinol Metab 78:381-386
7. Brummer RJ, Lonn L, Kvist H, Grangard U, Bengtsson BA, Sjostrom L 1993 Adipose tissue and muscle volume determination by computed tomography in acromegaly, before and 1 year after adenomectomy. Eur J Clin Invest 23:199-205
8. Goodpaster BH, Thaete FL, Kelley DE 2000 Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr 71:885-892
9. Albu JB, Kovera AJ, Allen L, Wainwright M, Berk E, Raja-Khan N, Janumala I, Burkey B, Heshka S, Gallagher D 2005 Independent association of insulin resistance with larger amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white nondiabetic women. Am J Clin Nutr 82:1210-1217
10. Song MY, Ruts E, Kim J, Janumala I, Heymsfield S, Gallagher D 2004 Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women. Am J Clin Nutr 79:874-880
11. Gallagher D, Kuznia P, Heshka S, Albu J, Heymsfield SB, Goodpaster B, Visser M, Harris TB 2005 Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue. Am J Clin Nutr 81:903-910
12. Kim J, Heshka S, Gallagher D, Kotler DP, Mayer L, Albu J, Shen W, Freda PU, Heymsfield SB 2004 Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy x-ray absorptiometry in adults. J Appl Physiol 97:655-660
13. Efron B 1983 Estimating the error rate of a prediction rule: improvements on crossvalidation. J Am Stat Assoc 78:316-331
14. Bland JM, Altman DG 1986 Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:307-310
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
16. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ 2000 Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402-2410
17. Matsuda M, DeFronzo RA 1999 Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462-1470
18. Nam SY, Lobie PE 2000 The mechanism of effect of growth hormone on preadipocyte and adipocyte function. Obes Rev 1:73-86
19. Richelsen B 1997 Action of growth hormone in adipose tissue. Horm Res 48(Suppl 5):105-110
20. Yang S, Mulder H, Holm C, Eden S 2004 Effects of growth hormone on the function of β-adrenoceptor subtypes in rat adipocytes. Obes Res 12:330-339
21. Richelsen B, Pedersen SB, Kristensen K, Borglum JD, Norrelund H, Christiansen JS, Jorgensen JO 2000 Regulation of lipoprotein lipase and hormone-sensitive lipase activity and gene expression in adipose and muscle tissue by growth hormone treatment during weight loss in obese patients. Metabolism 49:906-911
22. Ottosson M, Vikman-Adolfsson K, Enerback S, Elander A, Bjorntorp P, Eden S 1995 Growth hormone inhibits lipoprotein lipase activity in human adipose tissue. J Clin Endocrinol Metab 80:936-941
23. Simsolo RB, Ezzat S, Ong JM, Saghizadeh M, Kern PA 1995 Effects of acromegaly treatment and growth hormone on adipose tissue lipoprotein lipase. J Clin Endocrinol Metab 80:3233-3238
24. Moller N, Schmitz O, Joorgensen JO, Astrup J, Bak JF, Christensen SE, Alberti KG, Weeke J 1992 Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy. J Clin Endocrinol Metab 74:1012-1019
25. Lafontan M, Berlan M 2003 Do regional differences in adipocyte biology provide new pathophysiological insights? Trends Pharmacol Sci 24:276-283
26. Hoffstedt J, Arner P, Hellers G, Lonnqvist F 1997 Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men. J Lipid Res 38:795-804
27. Richelsen B, Pedersen SB, Moller-Pedersen T, Bak JF 1991 Regional differences in triglyceride breakdown in human adipose tissue: effects of catecholamines, insulin, and prostaglandin E2. Metabolism 40:990-996
28. Bengtsson BA, Eden S, Lonn L, Kvist H, Stokland A, Lindstedt G, Bosaeus I, Tolli J, Sjostrom L, Isaksson OG 1993 Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab 76:309-317
29. Snel YE, Brummer RJ, Doerga ME, Zelissen PM, Bakker CJ, Hendriks MJ, Koppeschaar HP 1995 Adipose tissue assessed by magnetic resonance imaging in growth hormone-deficient adults: the effect of growth hormone replacement and a comparison with control subjects. Am J Clin Nutr 61:1290-1294
30. Johannsson G, Marin P, Lonn L, Ottosson M, Stenlof K, Bjorntorp P, Sjostrom L, Bengtsson BA 1997 Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab 82:727-734
31. Engelson ES, Glesby MJ, Mendez D, Albu JB, Wang J, Heymsfield SB, Kotler DP 2002 Effect of recombinant human growth hormone in the treatment of visceral fat accumulation in HIV infection. J Acquir Immune Defic Syndr 30:379-391
32. Koutkia P, Canavan B, Breu J, Torriani M, Kissko J, Grinspoon S 2004 Growth hormone-releasing hormone in HIV-infected men with lipodystrophy: a randomized controlled trial. JAMA 292:210-218
33. Bluher S, Kratzsch J, Kiess W 2005 Insulin-like growth factor I, growth hormone and insulin in white adipose tissue. Best Pract Res Clin Endocrinol Metab 19:577-587
34. Clemmons DR 2006 Involvement of insulin-like growth factor-I in the control of glucose homeostasis. Curr Opin Pharmacol 6:620-625
35. Fischer-Posovszky P, Tornqvist H, Debatin KM, Wabitsch M 2004 Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like growth factor I (IGF-I)/IGF-I receptor autocrine circuit. Endocrinology 145:1849-1859
36. Scavo LM, Karas M, Murray M, Leroith D 2004 Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes. J Clin Endocrinol Metab 89:3543-3553
37. Brummer RJ, Bengtsson BA, Bosaeus I 1992 Validation of body composition determination by bioelectrical impedance analysis in acromegaly. Eur J Clin Nutr 46:47-52
38. Bengtsson BA, Brummer RJ, Eden S, Bosaeus I 1989 Body composition in acromegaly. Clin Endocrinol (Oxf) 30:121-130
39. Brummer RJ, Lonn L, Bengtsson BA, Kvist H, Bosaeus I, Sjostrom L 1996 Comparison of different body composition models in acromegaly. Growth Regul 6:191-200
40. Hu HY, Yamamoto H, Sohmiya M, Abe T, Murakami Y, Kato Y 1994 Body composition assessed by bioelectrical impedance analysis (BIA) and the correlation with plasma insulin-like growth factor I (IGF-I) in normal Japanese subjects and patients with acromegaly and GH deficiency. Endocr J [Erratum (1996) 43:following 130] 41:63-69
41. Kaji H, Sugimoto T, Nakaoka D, Okimura Y, Kaji H, Abe H, Chihara K 2001 Bone metabolism and body composition in Japanese patients with active acromegaly. Clin Endocrinol (Oxf) 55:175-181
42. Goodpaster BH, Krishnaswami S, Resnick H, Kelley DE, Haggerty C, Harris TB, Schwartz AV, Kritchevsky S, Newman AB 2003 Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care 26:372-379
43. Yim JE, Heshka S, Albu J, Heymsfield S, Kuznia P, Harris T, Gallagher D 2007 Intermuscular adipose tissue rivals visceral adipose tissue in independent associations with cardiovascular risk. Int J Obes (Lond) 31:1400-1405
44. Albu JB, Kenya S, He Q, Wainwright M, Berk ES, Heshka S, Kotler DP, Engelson ES 2007 Independent associations of insulin resistance with high whole-body intermuscular and low leg subcutaneous adipose tissue distribution in obese HIV-infected women. Am J Clin Nutr 86:100-106
45. Joy T, Grinspoon SK 2007 Adipose compartmentalization and insulin resistance among obese HIV-infected women: the role of intermuscular adipose tissue. Am J Clin Nutr 86:5-6
46. Richelsen B 1999 Effect of growth hormone on adipose tissue and skeletal muscle lipoprotein lipase activity in humans. J Endocrinol Invest 22:10-15
47. Rabinowitz D, Klassen GA, Zierler KL 1965 Effect of human growth hormone on muscle and adipose tissue metabolism in the forearm of man. J Clin Invest 44:51-61
48. Rabinowitz D, Zierler KL 1963 Differentiation of active from inactive acromegaly by studies of forearm metabolism and response to intra-arterial insulin. Bull Johns Hopkins Hosp 113:211-224
49. Krag MB, Gormsen LC, Guo Z, Christiansen JS, Jensen MD, Nielsen S, Jorgensen JO 2007 Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDL-triglyceride kinetics. Am J Physiol Endocrinol Metab 292:E920-E927
50. Fineberg SE, Merimee TJ, Rabinowitz D, Edgar PJ 1970 Insulin secretion in acromegaly. J Clin Endocrinol Metab 30:288-292
51. Hansen I, Tsalikian E, Beaufrere B, Gerich J, Haymond M, Rizza R 1986 Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action. Am J Physiol 250:E269-E273
52. Luger A, Prager R, Gaube S, Graf H, Klauser R, Schernthaner G 1990 Decreased peripheral insulin sensitivity in acromegalic patients. Exp Clin Endocrinol 95:339-343
53. Foss MC, Saad MJ, Paccola GM, Paula FJ, Piccinato CE, Moreira AC 1991 Peripheral glucose metabolism in acromegaly. J Clin Endocrinol Metab 72:1048-1053
54. Nielsen S, Moller N, Christiansen JS, Jorgensen JO 2001 Pharmacological antilipolysis restores insulin sensitivity during growth hormone exposure. Diabetes 50:2301-2308
55. Boden G 2006 Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver. Curr Diab Rep 6:177-181
56. Dominici FP, Turyn D 2002 Growth hormone-induced alterations in the insulin-signaling system. Exp Biol Med (Maywood) 227:149-157
57. Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI 2002 Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236
58. Randle PJ 1998 Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14:263-283
59. Jorgensen JO, Jessen N, Pedersen SB, Vestergaard E, Gormsen L, Lund SA, Billestrup N 2006 GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus. Am J Physiol Endocrinol Metab 291:E899-E905
60. Torriani M, Grinspoon S 2005 Racial differences in fat distribution: the importance of intermuscular fat. Am J Clin Nutr 81:731-732
61. Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, Haring HU 1999 Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48:1113-1119
62. Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, Roden M, Shulman GI 1999 Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42:113-116
63. Boden G, Lebed B, Schatz M, Homko C, Lemieux S 2001 Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50:1612-1617
64. Moller N, Jorgensen JO, Alberti KG, Flyvbjerg A, Schmitz O 1990 Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab 70:1179-1186
65. Moller N, Butler PC, Antsiferov MA, Alberti KG 1989 Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man. Diabetologia 32:105-110
66. Bengtsson BA, Brummer RJ, Eden S, Bosaeus I, Lindstedt G 1989 Body composition in acromegaly: the effect of treatment. Clin Endocrinol (Oxf) 31:481-490
67. Landin K, Petruson B, Jakobsson KE, Bengtsson BA 1993 Skeletal muscle sodium and potassium changes after successful surgery in acromegaly: relation to body composition, blood glucose, plasma insulin and blood pressure. Acta Endocrinol (Copenh) 128:418-422
68. McLellan AR, Connell JM, Beastall GH, Teasdale G, Davies DL 1988 Growth hormone, body composition and somatomedin C after treatment of acromegaly. Q J Med 69:997-1008
69. Tominaga A, Arita K, Kurisu K, Uozumi T, Migita K, Eguchi K, IIda K, Kawamoto H, Mizoue T 1998 Effects of successful adenomectomy on body composition in acromegaly. Endocr J 45:335-342
70. Barkan AL, Beitins IZ, Kelch RP 1988 Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: correlation with the degree of growth hormone hypersecretion. J Clin Endocrinol Metab 67:69-73
71. Clemmons DR, Van Wyk JJ, Ridgway EC, Kliman B, Kjellberg RN, Underwood LE 1979 Evaluation of acromegaly by radioimmunoassay of somatomedin-C. N Engl J Med 301:1138-1142
72. Puder JJ, Nilavar S, Post KD, Freda PU 2005 Relationship between disease-related morbidity and biochemical markers of activity in patients with acromegaly. J Clin Endocrinol Metab 90:1972-1978