Neonatal dexamethasone administration causes progressive renal damage due to induction of an early inflammatory response

American Journal of Physiology - Renal Physiology

Volumn 294, Issue 4, 2008, Pages

  Liu, Yan ^a,c   Van Goor, Harry ^a   Havinga, Rick ^a   Baller, Julius F W ^a   Bloks, Vincent W ^a   Van Der Leij, Feike R ^a,b   Sauer, Pieter J J ^a   Kuipers, Folkert ^a   Navis, Gerjan ^a   De Borst, Martin H ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b University of Applied Sciences   (Netherlands)

^c HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Glucocorticoids; Inflammation; Kidney failure; Newborn

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; DEXAMETHASONE; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GROWTH RETARDATION; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY INJURY; MALE; NEPHRITIS; NEWBORN; NEWBORN DEATH; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEINURIA; RAT; SYSTOLIC BLOOD PRESSURE; ANIMAL; BLOOD PRESSURE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; INFLAMMATION; KIDNEY; NEPHRON; PATHOLOGY; PREGNANCY; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; BLOOD GLUCOSE; BLOOD PRESSURE; DEXAMETHASONE; FEMALE; INFLAMMATION; KIDNEY; MALE; NEPHRONS; PREGNANCY; PROTEINURIA; RATS; RATS, WISTAR;

EID: 44949260123     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00163.2007     Document Type: Article

References (39)

1. Committee on Fetus and Newborn Infants. Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infants. Pediatrics 109: 330-338, 2002.
2. Arndt PG, Suzuki N, Avdi NJ, Malcolm KC, Worthen GS. Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-kinase and Syk-mediated pathways. J Biol Chem 279: 10883-10891, 2004.
3. Badid C, Vincent M, Fouque D, Laville M, Desmouliere A. Myofibroblast: a prognostic marker and target cell in progressive renal disease. Ren Fail 23: 543-549, 2001.
4. Bal MP, de Vries WB, van der Leij FR, van Oosterhout MF, Berger RM, Baan J, van der Wall EE, van Bel F, Steendijk P. Neonatal glucocorticosteroid treatment causes systolic dysfunction and compensatory dilation in early life: studies in 4-week-old prepubertal rats. Pediatr Res 58: 46-52, 2005.
5. Bertram JF. Analyzing renal glomeruli with the new stereology. Int Rev Cytol 161: 111-172, 1995.
6. Bolkenius U, Hahn D, Gressner AM, Breitkopf K, Dooley S, Wickert L. Glucocorticoids decrease the bioavailability of TGF-beta which leads to a reduced TGF-beta signaling in hepatic stellate cells. Biochem Biophys Res Commun 325: 1264-1270, 2004.
7. Bruna A, Nicolas M, Munoz A, Kyriakis JM, Caelles C. Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids. EMBO J 22: 6035-6044, 2003.
8. Caelles C, Gonzalez-Sancho JM, Munoz A. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev 11: 3351-3364, 1997.
9. Carroll MF, Temte JL. Proteinuria in adults: a diagnostic approach. Am Fam Physician 62: 1333-1340, 2000.
10. Coelho MS, Passadore MD, Gasparetti AL, Bibancos T, Prada PO, Furukawa LL, Furukawa LN, Fukui RT, Casarini DE, Saad MJ, Luz J, Chiavegatto S, Dolnikoff MS, Heimann JC. High- or low-salt diet from weaning to adulthood: effect on body weight, food intake and energy balance in rats. Nutr Metab Cardiovasc Dis 16: 148-155, 2006.
11. Cranefield DJ, Odd DE, Harding JE, Teele RL. High incidence of nephrocalcinosis in extremely preterm infants treated with dexamethasone. Pediatr Radiol 34: 138-142, 2004.
12. Cullen-McEwen LA, Kett MM, Dowling J, Anderson WP, Bertram JF. Nephron number, renal function, and arterial pressure in aged GDNF heterozygous mice. Hypertension 41: 335-340, 2003.
13. de Borst MH, Prakash J, Melenhorst WB, van den Heuvel MC, Kok RJ, Navis G, van Goor H. Glomerular and tubular induction of the transcription factor c-Jun in human renal disease. J Pathol 213: 219-228, 2007.
14. Dickinson H, Walker DW, Wintour EM, Moritz K. Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse. Am J Physiol Regul Integr Comp Physiol 292: R453-R461, 2007.
15. Dodic M, May CN, Wintour EM, Coghlan JP. An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clin Sci (Lond) 94: 149-155, 1998.
16. Dodic M, Moritz K, Koukoulas I, Wintour EM. Programmed hypertension: kidney, brain or both? Trends Endocrinol Metab 13: 403-408, 2002.
17. Figueroa JP, Rose JC, Massmann GA, Zhang J, Acuna G. Alterations in fetal kidney development and elevations in arterial blood pressure in young adult sheep after clinical doses of antenatal glucocorticoids. Pediatr Res 58: 510-515, 2005.
18. Huysman MW, Hokken-Koelega AC, Hop WC, Sauer PJ. Effect of dexamethasone treatment on serum GH, IGF-I, and the binding proteins IGFBP-1 and -3 in ventilated very preterm infants. Pediatr Res 54: 37-43, 2003.
19. Ikezumi Y, Atkins RC, Nikolic-Paterson DJ. Interferon-gamma augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism. J Am Soc Nephrol 14: 888-898, 2003.
20. Kamitsuka MD, Williams MA, Nyberg DA, Fox KA, Lee DL, Hickok D. Renal calcification: a complication of dexamethasone therapy in preterm infants with bronchopulmonary dysplasia. J Perinatol 15: 359-363, 1995.
21. Kamphuis PJ, Croiset G, Bakker JM, Van Bel F, Van Ree JM, Wiegant VM. Neonatal dexamethasone treatment affects social behaviour of rats in later life. Neuropharmacology 47: 461-474, 2004.
22. Kamphuis PJ, de Vries WB, Bakker JM, Kavelaars A, van Dijk JE, Schipper ME, van Oosterhout MF, Croiset G, Heijnen CJ, van Bel F, Wiegant VM. Reduced life expectancy in rats after neonatal dexamethasone treatment. Pediatr Res 61: 72-76, 2007.
23. Khan SB, Cook HT, Bhangal G, Smith J, Tam FW, Pusey CD. Antibody blockade of TNF-alpha reduces inflammation and scarring in experimental crescentic glomerulonephritis. Kidney Int 67: 1812-1820, 2005.
24. Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int 69: 213-217, 2006.
25. Moritz KM, Wintour EM. Functional development of the meso- and metanephros. Pediatr Nephrol 13: 171-178, 1999.
26. Neal CR Jr, Weidemann G, Kabbaj M, Vazquez DM. Effect of neonatal dexamethasone exposure on growth and neurological development. Am J Physiol Regul Integr Comp Physiol 287: R375-R385, 2004.
27. Noronha IL, Fujihara CK, Zatz R. The inflammatory component in progressive renal disease-are interventions possible? Nephrol Dial Transplant 17: 363-368, 2002.
28. Nyirenda MJ, Welberg LA, Seckl JR. Programming hyperglycaemia in the rat through prenatal exposure to glucocorticoids-fetal effect or maternal influence? J Endocrinol 170: 653-660, 2001.
29. Ortiz LA, Quan A, Zarzar F, Weinberg A, Baum M. Prenatal dexamethasone programs hypertension and renal injury in the rat. Hypertension 41: 328-334, 2003.
30. Plosch T, van der Veen JN, Havinga R, Huijkman NC, Bloks VW, Kuipers F. Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. Am J Physiol Gastrointest Liver Physiol 291: G414-G423, 2006.
31. Prodjosudjadi W, Gerritsma JS, Klar-Mohamad N, Gerritsen AF, Bruijn JA, Daha MR, van Es LA. Production and cytokine-mediated regulation of monocyte chemoattractant protein-1 by human proximal tubular epithelial cells. Kidney Int 48: 1477-1486, 1995.
32. Sean Eardley K, Cockwell P. Macrophages and progressive tubulointerstitial disease. Kidney Int 68: 437-455, 2005.
33. Slotkin TA, Seidler FJ, Kavlock RJ, Bartolome JV. Fetal dexamethasone exposure impairs cellular development in neonatal rat heart and kidney: effects on DNA and protein in whole tissues. Teratology 43: 301-306, 1991.
34. Smink JJ, Koedam JA, Koster JG, van Buul-Offers SC. Dexamethasone-induced growth inhibition of porcine growth plate chondrocytes is accompanied by changes in levels of IGF axis components. J Endocrinol 174: 343-352, 2002.
35. Tesch GH, Schwarting A, Kinoshita K, Lan HY, Rollins BJ, Kelley VR. Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis. J Clin Invest 103: 73-80, 1999.
36. van der Veen JN, Kruit JK, Havinga R, Baller JF, Chimini G, Lestavel S, Staels B, Groot PH, Groen AK, Kuipers F. Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1. J Lipid Res 46: 526-534, 2005.
37. Waanders F, Greven WL, Baynes JW, Thorpe SR, Kramer AB, Nagai R, Sakata N, van Goor H, Navis G. Renal accumulation of pentosidine in non-diabetic proteinuria-induced renal damage in rats. Nephrol Dial Transplant 20: 2060-2070, 2005.
38. Wang N, Verna L, Hardy S, Forsayeth J, Zhu Y, Stemerman MB. Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human endothelial cells. Arterioscler Thromb Vasc Biol 19: 2078-2084, 1999.
39. Xiao J, Chodosh J. JNK regulates MCP-1 expression in adenovirus type 19-infected human corneal fibroblasts. Invest Ophthalmol Vis Sci 46: 3777-3782, 2005.