Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

Journal of the International Society of Sports Nutrition

Volumn 4, Issue , 2007, Pages

  Rohle, Dan ^a   Wilborn, Colin ^b   Taylor, Lem ^c   Mulligan, Chris ^d   Kreider, Richard ^e   Willoughby, Darryn ^e  

^a Weill Cornell Medical Center   (United States)

^b UNIVERSITY OF MARY HARDIN BAYLOR   (United States)

^c UNIVERSITY OF WEST FLORIDA   (United States)

^d Department of Environmental and Radiological Health Sciences   (United States)

^e BAYLOR UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 44949259958     PISSN: None     EISSN: 15502783     Source Type: Journal    
DOI: 10.1186/1550-2783-4-13     Document Type: Article

References (27)

1. Bhasin S Storer T Berman N Yarasheski K Clevenger B Phillips J Lee W Bunnell T Casaburi R Testosterone replacement increases fat-free mass and muscle size in hypogonadal men J Clin Endocrinol Metab 1997, 82:407-13 10.1210/jc.82.2.407 9024227
2. Bhasin S Storer T Javanbakht M Berman N Yarasheski K Phillips J Dike M Sinha-Hikim I Shen R Hays R Beall G Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels JAMA 2000, 283: 763-70 10.1001/jama.283.6.763 10683055
3. Bhasin S Woodhouse L Casaburi R Singh A Bhasin D Berman Chen X Yarasheski K Magliano L Dzekov C Dzekov J Bross R Phillips J Sinha-Hikim I Shen R Storer T Testosterone dose-response relationships in healthy young men Am J Physiol Endocrinol Metab 2001, 281:E1172-81 11701431
4. Bhasin S Woodhouse L Storer T Proof of the effect of testosterone on skeletal muscle J Endocrinol 2001, 170:27-38 10.1677/joe.0.1700027 11431134
5. Sinha-Hikim I Artaza J Woodhouse L Gonzalez-Cadavid N Singh A Lee M Storer T Casaburi R Shen R Bhasin S Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy Am J Physiol Endocrinol Metab 2002, 283(1):E154-E164 12067856
6. Sinha-Hikim I Roth S Lee M Bhasin S Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men Am J Physiol Endocrinol Metab 2003, 285:E197-E205 12670837
7. Schroeder E Terk M Sattler F Androgen therapy improves muscle mass and strength but not muscle quality: Results from two studies Am J Physiol Endocrinol Metab 2003, 285:E16-24 12637255
8. Brown G Martini E Roberts S Vukovich M King D Acute hormonal response to sublingual androstenediol intake in young men J Appl Physiol 2002, 92:142-46 11744653
9. Brown G McKenzie D Acute resistance exercise does not change the hormonal response to sublingual androstenediol intake Eur J Appl Physiol 2006, 97:404-12 10.1007/s00421-006-0194-9 16636857
10. Broeder C Quindry J Brittingham K Panton L Thomson J Appakondu S Physiological and hormonal influences on androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program Arch Intern Med 2000, 160:3093-104 10.1001/ archinte.160.20.3093 11074738
11. King D Sharp R Vukovich M Brown G Reifenrath T Uhl N Parsons K Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men JAMA 1999, 281:2020-28 10.1001/jama.281.21.2020 10359391
12. Beckham S Earnest C Four weeks of androstenedione supplementation diminishes the treatment response in middle aged men Br J Sports Med 2003, 37:212-18 10.1136/bjsm.37.3.212 12782545
13. Mauras N O'Brien K Klein K Hayes V Estrogen suppression in males: metabolic effects J Clin Endocrinol Metab 2000, 85:2370-77 10.1210/ jc.85.7.2370 10902781
14. Mauras N Lima J Patel D Rini A diSalle E Kwok A Lippe B Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males J Clin Endocrinol Metab 2003, 88:5951-56 10.1210/ jc.2003-031279 14671195
15. Taxel P Kennedy D Fall P Willard A Clive J Raisz L The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men J Clin Endocrinol Metab 2001, 86:2869-74 10.1210/ jc.86.6.2869 11397902
16. Willoughby D Wilborn C Taylor L Campbell B Eight weeks of aromatase inhibition using the nutritional supplement Novedex XT: Effects on steroid hormones, body composition, and clinical safety markers in young, eugonadal men Int J Sport Nutr Exerc Metab 2007, 17(1):92-108 17460335
17. Numazawa M Tsuji M Mutsumi A Studies on aromatase inhibition with 4-androstene-3,6,17-trione: Its 3 beta-reduction and time-dependent irreversible binding to aromatase with human placental microsomes J Steroid Biochem 1997, 28:337-44 10.1016/0022-4731(87)91028-4
18. Numazawa M Mutsumi A Tachibana M Mechanism for aromatase inactivation by a suicide substrate, androst-4-ene-3,6,17-trione. The 4 beta, 5 beta-epoxy-19-oxo derivative as a reactive electrophile irreversibly binding to the active site Biochem Pharmacol 1996, 52:1253-59 10.1016/ 0006-2952(96)00479-0 8937433
19. Leder B Rohrer J Rubin S Gallo J Longcope C Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels J Clin Endocrinol Metab 2004, 89:1174-80 10.1210/jc.2003-031467 15001605
20. O'Connor K Stip E Pélissier M Aardema F Guay S Guadette M Van Haaster I Robillard S Grenier S Careau Y Doucet P Leblanc V Treating delusional disorder: A comparison of cognitive-behavioural therapy and attention placebo control Can J Psychiatry 2007, 52(3):182-190 17479527
21. Hossian A Hornick C Androgenic modulation of lipid metabolism at subcellular sties in cholestatic rats Horm Metab Res 1994, 26:19-25 8150419
22. Mauras N Rini A Welch S Sager B Murphy SP Synergistic effects of testosterone and growth hormone on protein metabolism and body composition in prepubertal boys Metabolism 2003, 52(8):964-969 10.1016/ S0026-0495(03)00163-X 12898459
23. Harden C MacLusky N Aromatase inhibition, testosterone, and seizures Epilepsy Behav 2004, 5:260-63 10.1016/j.yebeh.2003.12.001 15123030
24. Incledon T The chronic effects of androst-4-ene-3,6,17-trione on endocrine responses in resistance-trained men Unpublished observations 2003
25. Meinhardt U Mullis P The aromatase cytochrome P-450 and its clinical impact Horm Res 2002, 57:145-52 10.1159/000058374 12053085
26. Hayes F Seminara S Decruz S Boepple P Crowley W Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback J Clin Endocrinob Metab 2000, 85:3027-35 10.1210/jc.85.9.3027
27. Schnorr J Bray M Veldhuis J Aromatization mediates testosterone's short-term feedback restraint of 24-hour endogenously driven and acute exogenous gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone secretion in young men J Clin Endocrinol Metab 2001, 86:2600-06 10.1210/jc.86.6.2600 11397860