Four weeks of androstenedione supplementation diminishes the treatment response in middle aged men

British Journal of Sports Medicine

Volumn 37, Issue 3, 2003, Pages 212-218

  Beckham, S G ^a   Earnest, C P ^b  

^a UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

^b Cooper Institute for Aerobics Research ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; ESTRADIOL; PLACEBO; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE; BODY COMPOSITION; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; HEART RATE; HORMONE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL;

EID: 0037780903     PISSN: 03063674     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjsm.37.3.212     Document Type: Article

References (29)

1. Harman S, Tsitouras P. Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin. J Clin Endocrinol Metab 1980;51:35-40.
2. Kent J, Acone A. Androgens in pathological conditions. In: Vermeulen A, Exley D, eds. Plasma testosterone levels and aging in males. Amsterdam: Excerpta Medica Foundation ICS, 1966.
3. Lipsett M. Steroid secretion by the human testis. In: Rosenmberg E, Paulsen C, eds. The human testis. New York: Plenum Press, 1970.
4. Tsitouras P, Martin C, Harman S. Relationship of serum testosterone to sexual activity in healthy elderly men. J Gerontol 1982;37:288-93.
5. Wilson J, Foster D, Kronenberg H, et al, eds. Williams textbook of endocrinology. 9th ed. Philadelphia: WB Saunders, 1998.
6. Ballantyne C, Phillips S, MacDonald J, et ol. The acute effects of androstenedione supplementation in healthy young males. Can J Appl Physiol 2000;25:68-78.
7. Broeder C, Quindry J, Brittingham K, et al. The andro proiect: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high intensity resistance training program. Arch Intern Med 2000;160:3090-104.
8. Brown G, Vukovich M, Martini E, et al. Endocrine responses to chronic androstenedione intake in 30- to 56-old men. J Clin Endocrinol Metab 2000;85:4074-80.
9. Earnest C, Olson M, Broeder C, et al. In vivo 4-androstene-3, 17-dione and 4-androstene-3beta, 17beta-diol supplementation in young men. Eur J Appl Physiol 2000;81:229-32.
10. King D, Sharp R, Vukovich M, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men. JAMA 1999;281:2020-8.
11. Leder B, Longscope C, Catlin D, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000;283:779-82.
12. Rasmussen B, Volpi E, Gore D, et al. Androstenedione does not simulate muscle protein anabolism in young health men. J Clin Endocrinol Metab 2000;85:55-9.
13. Wilmore J, Vodak P, Parr R, et al. Further simplification of a method for determination of residual lung volume. Med Sci Sports Exerc 1980;12:216-18.
14. Siri W. Body composition from fluid spaces and density. In: Brozek J, Henschel A, eds. Techniques for measuring body composition. Washington, DC: National Academy of Science, 1961.
15. Meikle A, Stringham J, Woodward M, et al. Effects of a fat-containing meal on sex hormones in men. Metabolism 1990;39:943-6.
16. McNair D, Lorr M, Droppleman L. Profile of mood states. San Diego: EdITS/Educational and Industrial Testing Service, 1992.
17. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. New York: Marcel Dekker, 1982.
18. Persky H, Smith K, Basu G. Relation of psychologic measures of aggression and hostility to testosterone production in man. Psychosom Med 1971;33:265.
19. Vermeulen a, Bubens R, Verdonick L. Testosterone secretion and metabolism in male senescence. J Clin Endocrinol Metab 1972;34:730.
20. Greenspan F, ed. Basic and clinical endocrinology. 3rd ed. East Norwalk: Appleton & Lange, 1991.
21. Longscope C, Kato T, Hortan R. Conversion of blood androgens to estrogens in normal adult men and women. J Clin Invest 1969;48:2191-201.
22. Dunn J, Nisula B, Rodbard D. The relationship between sex steroids and sex-hormone-binding globulin in plasma in physiological and pathological conditions. Ann Clin Biochem 1981;22:489-97.
23. Plymate S, Leonard J, Paulsen C, et al. Sex hormone-binding globulin changes with androgen replacement. J Clin Endocrinol Metab 1983;57:645-8.
24. Rosner W. The functions of corticosteriod-binding globulin and sex hormone-binding globulin: recent advances. Endocrinol Rev 1990;11:80-91.
25. von Schoultz B, Carlstrom K. General review: on the regulation of sex-hormone-binding globulin: challenge of an old dogma and outlines of an alternative mechanism. J Steroid Biochem 1989;32:327-34.
26. Wallace M, Lim J, Cutler A, et al. Effects of dehydroepiandrosterone vs androstenedione supplementation in men. Med Sci Sports Exerc 1999;31:1788-92.
27. Pardridge W. Transport of protein-bound hormones into tissues in vivo. Endocrinol Rev 1981;2:103-23.
28. Mean F, Pellaton M, Magrini G. Study on the binding of dihydrotestosterone, testosterone and oestradiol with sex hormone binding globulin. Clin Chim Acta 1977;80:171-80.
29. Oshima H, Fan D-F, Troen P. Studies of the human testis. v. properties of delta 5-3beta and 17beta-hydroxysteroid dehydrogenases in the biosynthesis of testosterone from dehydroepiandrosterone. J Clin Endocrinol Metab 1975;40:573-81.