Hepatic Disorders Severely Affected by Pregnancy: Medical and Obstetric Management

Medical Clinics of North America

Volumn 92, Issue 4, 2008, Pages 739-760

  Cappell, Mitchell S ^a  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; HEMATIN; HEPARIN; LACTATE DEHYDROGENASE; URSODEOXYCHOLIC ACID;

ACUTE INTERMITTENT PORPHYRIA; ANEURYSM; BUDD CHIARI SYNDROME; CHOLECYSTECTOMY; CLINICAL FEATURE; COMMON BILE DUCT CYST; DISEASE SEVERITY; ECLAMPSIA; FEMALE; FIBRINOLYTIC THERAPY; HELLP SYNDROME; HEPATITIS E; HERPES SIMPLEX; HUMAN; HYPEREMESIS GRAVIDARUM; INTRAHEPATIC CHOLESTASIS; LIVER ADENOMA; LIVER DISEASE; LIVER FATTY DEGENERATION; LIVER FUNCTION TEST; LIVER HEMORRHAGE; LIVER RUPTURE; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; PREECLAMPSIA; PREGNANCY COMPLICATION; PRIORITY JOURNAL; REVIEW; SPLEEN ARTERY; THROMBOCYTE COUNT; TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT;

FEMALE; HUMANS; LIVER DISEASES; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; PREGNANCY; PREGNANCY COMPLICATIONS;

EID: 44949206579     PISSN: 00257125     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcna.2008.03.002     Document Type: Review

References (104)

1. Cappell M.S., and Friedel D. Abdominal pain during pregnancy. Gastroenterol Clin North Am 32 1 (2003) 1-58
2. Cappell M.S. Colon cancer during pregnancy. Gastroenterol Clin North Am 32 1 (2003) 341-383
3. Briggs G.C., Freeman R.K., and Yaffe S.J. Drugs in pregnancy and lactation: a reference guide to fetal and maternal risk. 7th edition (2005), Lippincott, Williams & Wilkens, Philadelphia
4. Ch'ng C.L., Morgan M., Hainsworth I., et al. Prospective study of liver dysfunction in pregnancy in Southwest Wales. Gut 51 6 (2002) 876-880
5. Knox T.A., and Olans L.B. Liver disease in pregnancy. N Engl J Med 335 8 (1996) 569-576
6. Riely C.A. Liver disease in the pregnant patient; American College of Gastroenterology. Am J Gastroenterol 94 7 (1999) 1728-1732
7. Lipsett P.A., Pitt H.A., Colombani P.M., et al. Choledochal cyst disease: a changing pattern of presentation. Ann Surg 220 5 (1994) 644-652
8. Todani T., Watanabe Y., Toki A., et al. Classification of congenital biliary cystic disease: special reference to type 1C and IVA cysts with primary ductal stricture. J Hepatobiliary Pancreat Surg 10 5 (2003) 340-344
9. Hewitt P.M., Krige J.E., Bornman P.C., et al. Choledochal cyst in pregnancy: a therapeutic dilemma. J Am Coll Surg 181 3 (1995) 237-240
10. Nassar A.H., Chakhtoura N., Martin D., et al. Choledochal cysts diagnosed in pregnancy: a case report and review of treatment options. J Matern Fetal Med 10 5 (2001) 363-365
11. Jackson B.T., and Saunders P. Perforated choledochus cyst. Br J Surg 58 1 (1971) 38-42
12. Voyles C.R., Smadja C., Shands W.C., et al. Carcinoma in choledochal cysts: age-related incidence. Arch Surg 118 8 (1983) 986-988
13. Lizardi-Cervera J., Cuellar-Gamboa L., and Motola-Kuba D. Focal nodular hyperplasia and hepatic adenoma: a review. Ann Hepatol 5 3 (2006) 206-211
14. Terkivatan T., de Wilt J.H., de Man R.A., et al. Management of hepatocellular adenoma during pregnancy. Liver 20 2 (2000) 186-187
15. Jeans J.B., Savik K., Gross C.R., et al. Mortality in patients with acute intermittent porphyria requiring hospitalization: a United States case series. Am J Med Genet 65 4 (1996) 269-273
16. Milo R., Neuman M., Klein C., et al. Acute intermittent porphyria in pregnancy. Obstet Gynecol 73 3 pt 2 (1989) 450-452
17. Dombeck T.A., and Satonik R.C. The porphyrias. Emerg Med Clin North Am 23 3 (2005) 885-899
18. Pasha S.F., Gloviczki P., Stanson A.W., et al. Splanchnic artery aneurysms. Mayo Clin Proc 82 4 (2007) 472-479
19. Wolf J.L. Liver disease in pregnancy. Med Clin North Am 80 5 (1996) 1167-1187
20. Singh V., Sinha S.K., Nain C.K., et al. Budd-Chiari syndrome: our experience of 71 patients. J Gastroenterol Hepatol 15 5 (2000) 550-554
21. Slakey D.P., Klein A.S., Venbrux A.C., et al. Budd-Chiari syndrome: current management options. Ann Surg 233 4 (2001) 522-527
22. Salha O., Campbell D.J., and Pollard S. Budd-Chiari syndrome in pregnancy treated by caesarean section and liver transplant. Br J Obstet Gynaecol 103 12 (1996) 1254-1256
23. Guntupalli S.R., and Steingrub J. Hepatic disease and pregnancy: an overview of diagnosis and management. Crit Care Med 33 10 Suppl (2005) S332-S339
24. Naik S.R., Aggarwal R., Salunke P.N., et al. A large waterborne viral hepatitis E epidemic in Kanpur, India. Bull World Health Organ 70 5 (1992) 597-604
25. Chau T.N., Lai S.T., Tse C., et al. Epidemiology and clinical features of sporadic hepatitis E as compared with hepatitis A. Am J Gastroenterol 101 2 (2006) 292-296
26. Patra S., Kumar A., Trivedi S.S., et al. Maternal and fetal outcomes in pregnant women with acute hepatitis E virus infection. Ann Intern Med 147 1 (2007) 28-33
27. Kumar A., Beniwal B., Kar P., et al. Hepatitis E in pregnancy. Int J Gynaecol Obstet 85 3 (2004) 240-244
28. Hamid S.S., Jafri S.M., Khan H., et al. Fulminant hepatic failure in pregnant women: acute fatty liver or acute viral hepatitis?. J Hepatol 25 1 (1996) 20-27
29. Takahashi M., Kusakai S., Mizuo H., et al. Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) is highly specific for diagnosis of acute HEV infection. J Clin Microbiol 43 1 (2005) 49-56
30. Krawczynski K. Hepatitis E vaccine: ready for prime time?. N Engl J Med 356 9 (2007) 949-951
31. Shrestha M.P., Scott R.M., Joshi D.M., et al. Safety and efficacy of a recombinant hepatitis E vaccine. N Engl J Med 356 9 (2007) 895-903
32. Kang A.H., and Graves C.R. Herpes simplex hepatitis in pregnancy: a case report and review of the literature. Obstet Gynecol Surv 54 7 (1999) 463-468
33. Haun L., Kwan N., and Hollier L.M. Viral infections in pregnancy. Minerva Ginecol 59 2 (2007) 159-174
34. Smith J.A., Espeland M., Bellevue R., et al. Pregnancy in sickle cell disease: experience of the Cooperative Study of Sickle Cell Disease. Obstet Gynecol 87 2 (1996) 199-204
35. Seoud M.A., Cantwell C., Nobles G., et al. Outcome of pregnancies complicated by sickle cell and sickle-C hemoglobinopathies. Am J Perinatol 11 3 (1994) 187-191
36. Davis A., Katz V.L., and Cox R. Gallbladder disease in pregnancy. J Reprod Med 40 11 (1995) 759-762
37. Serjeant G.R., Loy L.L., Crowther M., et al. Outcome of pregnancy in homozygous sickle cell disease. Obstet Gynecol 103 6 (2004) 1278-1285
38. Serjeant G.R., Hambleton I., and Thame M. Fecundity and pregnancy outcome in a cohort with sickle cell-haemoglobin C disease followed from birth. BJOG 112 9 (2005) 1308-1314
39. American Academy of Pediatrics. Committee on Substance Abuse and Committee on Children with Disabilities. Fetal alcohol syndrome and alcohol-related neurodevelopmental disorders. Pediatrics 106 2 Pt 1 (2000) 358-361
40. Habbick B.F., Zaleski W.A., Casey R., et al. Liver abnormalities in three patients with fetal alcohol syndrome. Lancet 1 8116 (1979) 580-581
41. Abell T., and Riely C. Hyperemesis gravidarum. Gastroenterol Clin North Am 21 4 (1992) 835-849
42. Kuscu N.K., and Koyuncu F. Hyperemesis gravidarum: current concepts and management. Postgrad Med 78 916 (2002) 76-79
43. Hay J.E. Liver disease in pregnancy. Hepatology 47 3 (2008) 1067-1076
44. Larrey D., Rueff B., Feldmann G., et al. Recurrent jaundice caused by recurrent hyperemesis gravidarum. Gut 25 12 (1984) 1414-1415
45. Hamaoui E., and Hamaoui M. Nutritional assessment and support during pregnancy. Gastroenterol Clin North Am 32 1 (2003) 59-121
46. Tsang I.S., Katz V.L., and Wells S.D. Maternal and fetal outcome in hyperemesis gravidarum. Int J Gynaecol Obstet 55 3 (1996) 231-235
47. Davidson K.M. Intrahepatic cholestasis of pregnancy. Semin Perinatol 22 2 (1998) 104-111
48. Reyes H., Wegmann M.E., Segovia N., et al. HLA in Chileans with intrahepatic cholestasis of pregnancy. Hepatology 2 4 (1982) 463-466
49. Benjaminov F.S., and Heathcote J. Liver disease in pregnancy. Am J Gastroenterol 99 12 (2004) 2479-2488
50. Reyes H., and Simon F.R. Intrahepatic cholestasis of pregnancy: an estrogen-related disease. Semin Liver Dis 13 3 (1993) 289-301
51. Sandhu B.S., and Sanyal A.J. Pregnancy and liver disease. Gastroenterol Clin North Am 32 1 (2003) 407-436
52. Floreani A., Carderi I., Paternostere D., et al. Intrahepatic cholestasis of pregnancy: three novel MDR3 gene mutations. Aliment Pharmacol Ther 23 11 (2006) 1649-1653
53. Mullally B.A., and Hansen W.F. Intrahepatic cholestasis of pregnancy: review of the literature. Obstet Gynecol Surv 57 1 (2002) 47-52
54. Heikkinen J. Serum bile acids in the early diagnosis of intrahepatic cholestasis of pregnancy. Obstet Gynecol 61 5 (1983) 581-587
55. Bacq Y., Zarka O., Brechot J.F., et al. Liver function tests in normal pregnancy: a prospective study of 103 pregnant women and 103 matched controls. Hepatology 23 5 (1996) 1030-1034
56. Rolfes D.B., and Ishak K.G. Liver disease in pregnancy. Histopathology 10 6 (1986) 555-570
57. Palma J., Reyes H., Ribalta J., et al. Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo. J Hepatol 27 6 (1997) 1022-1028
58. Kondrackiene J., Beuers U., and Kupcinskas L. Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy. Gastroenterology 129 3 (2005) 894-901
59. Zapata R., Sandoval L., Palma J., et al. Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: a 12-year experience. Liver Int 25 3 (2005) 548-554
60. Heinonen S., and Kirkinen P. Pregnancy outcome with intrahepatic cholestasis. Obstet Gynecol 94 2 (1999) 189-193
61. Bacq Y., Sapey T., Brechot M.C., et al. Intrahepatic cholestasis of pregnancy: a French prospective study. Hepatology 26 2 (1997) 358-364
62. Rioseco A.J., Ivankovic M.B., Manzur A., et al. Intrahepatic cholestasis of pregnancy: a retrospective case-control study of perinatal outcome. Am J Obstet Gynecol 170 3 (1994) 890-895
63. Williamson C., Helms L.M., Goulis D.G., et al. Clinical outcome in a series of cases of obstetric cholestasis identified via a patient support group. BJOG 111 7 (2004) 676-681
64. Castro M.A., Fassett M.J., Reynolds T.B., et al. Reversible peripartum liver failure: a new perspective on the diagnosis, treatment, and cause of acute fatty liver of pregnancy, based on 28 consecutive cases. Am J Obstet Gynecol 181 2 (1999) 389-395
65. Ibdah J.A. Acute fatty liver of pregnancy: an update on pathogenesis and clinical implications. World J Gastroenterol 12 46 (2006) 7397-7404
66. Treem W.R., Shoup M.E., Hale D.E., et al. Acute fatty liver of pregnancy hemolysis, elevated liver enzymes, and low platelets syndrome, and long chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. Am J Gastroenterol 91 11 (1996) 2293-2300
67. Ibdah J.A., Bennett M.J., Rinaldo P., et al. A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women. N Engl J Med 340 22 (1999) 1723-1731
68. Monga M., and Katz A.R. Acute fatty liver in the second trimester. Obstet Gynecol 93 5 pt. 2 (1999) 811-813
69. Mabie W.C. Acute fatty liver of pregnancy. Crit Care Clin 7 4 (1991) 799-808
70. Reyes H., Sandoval L., Wainstein A., et al. Acute fatty liver of pregnancy: a clinical study of 12 episodes in 11 patients. Gut 35 1 (1994) 101-106
71. Rahman T.M., and Wendon J. Severe hepatic dysfunction in pregnancy. QJM 95 (2002) 343-357
72. van Le L., and Podrasky A. Computed tomographic and ultrasonographic findings in women with acute fatty liver of pregnancy. J Reprod Med 35 8 (1990) 815-817
73. Walker J.J. Pre-eclampsia. Lancet 356 9237 (2000) 1260-1265
74. Barton J.R., and Sibai B.M. Care of the pregnancy complicated by HELLP syndrome. Gastroenterol Clin North Am 21 4 (1992) 937-950
75. Remiszewski P., Pawlak J., Shwarek A., et al. Orthotopic liver transplantation for acute liver failure resulting from "acute fatty liver of pregnancy". Ann Transplant 8 3 (2003) 8-11
76. Pereira S.P., O'Donohue J., Wendon J., et al. Maternal and perinatal outcome in severe pregnancy-related liver disease. Hepatology 26 5 (1997) 1258-1262
77. Saftlas A.F., Olson D.R., Franks A.L., et al. Epidemiology of preeclampsia and eclampsia in the United States, 1979-1986. Am J Obstet Gynecol 163 2 (1990) 460-465
78. Odegard R.A., Vatten L.J., Nilsen S.T., et al. Risk factors and clinical manifestations of pre-eclampsia. BJOG 107 11 (2000) 1410-1416
79. Sibai B.M. Pitfalls in diagnosis and management of preeclampsia. Am J Obstet Gynecol 159 2 (1988) 1-5
80. Bussen S., Suttterlin M., and Steck T. Plasma endothelin and big endothelin levels in women with severe pre-eclampsia or HELLP syndrome. Arch Gynecol Obstet 262 3-4 (1999) 113-119
81. Caniggia I., Winter J., Lye S.J., et al. Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia. Placenta 21 Suppl A (2000) s25-s30
82. Arias F., and Mancilla-Jimenez R. Hepatic fibrinogen deposits in pre-eclampsia: immunofluorescent evidence. N Engl J Med 295 11 (1976) 578-582
83. Rolfes D.B., and Ishak K.G. Liver disease in toxemia of pregnancy. Am J Gastroenterol 81 12 (1986) 1138-1144
84. Weinstein L. Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 142 2 (1982) 159-167
85. Minakami H., Oka N., Sato T., et al. Preeclampsia: a microvesicular fat disease of the liver?. Am J Obstet Gynecol 159 5 (1988) 1043-1047
86. Sibai B.M. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing?. Am J Obstet Gynecol 162 2 (1990) 311-316
87. Hepburn I.S. Pregnancy-associated liver disorders, Epublished. Dig Dis Sci. (February 7, 2008)
88. Saphier C.J., and Repke T. Hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome: a review of diagnosis and management. Semin Perinatol 22 2 (1998) 118-133
89. Tompkins M.J., and Thiagarajah S. HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome : the benefit of corticosteroids. Am J Obstet Gynecol 181 2 (1999) 304-309
90. Fonseca J.E., Mendez F., Catano C., et al. Dexamethasone treatment does not improve the outcome of women with HELLP syndrome: a double-blind, placebo-controlled, randomized clinical trial. Am J Obstet Gynecol 193 5 (2005) 1591-1598
91. Barton J.R., and Sibai B.M. Hepatic imaging in HELLP syndrome (hemolysis, elevated liver enzymes, low platelet count). Am J Obstet Gynecol 174 6 (1996) 1820-1825
92. Sheikh R.A., Yasmeen S., Pauly M.P., et al. Spontaneous intrahepatic hemorrhage and hepatic rupture in the HELLP syndrome: four cases and a review. J Clin Gastroenterol 28 4 (1999) 323-328
93. Henny C.P., Lim A.E., Brummelkamp W.H., et al. A review of the importance of acute multidisciplinary treatment following spontaneous rupture of the liver caspsule during pregnancy. Surg Gynecol Obstet 156 5 (1983) 593-598
94. Coelho T., Braga J., and Sequeira M. Hepatic hematomas in pregnancy. Acta Obstet Gynecol Scand 79 10 (2000) 884-886
95. Sibai B.M., Ramadan M.K., Usta I., et al. Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol 169 4 (1993) 1000-1006
96. Rinehart B.K., Terrone D.A., Magann E.F., et al. Preeclampsia-associated hepatic hemorrhage and rupture: mode of management related to maternal and perinatal outcome. Obstet Gynecol Surv 54 3 (1999) 196-202
97. Poo J.L., and Gongora J. Hepatic hematoma and hepatic rupture in pregnancy. Ann Hepatol 5 3 (2006) 224-226
98. Rademaker L. Spontaneous rupture of liver during pregnancy. Ann Surg 118 3 (1943) 396-401
99. Gyang A.N., Srivastava G., and Asaad K. Liver capsule rupture in eclampsia: treatment with hepatic artery embolization. Arch Gynecol Obstet 274 6 (2006) 377-379
100. Laifer S.A., and Guido R. Reproductive function and outcome of pregnancy after liver transplantation in women. Mayo Clin Proc 70 4 (1995) 388-394
101. Casele H.L., and Laifer S.A. Pregnancy after liver transplantation. Semin Perinatol 22 2 (1998) 149-155
102. Armenti V.T., Herrine S.K., Radomski J.S., et al. Pregnancy after liver transplantation. Liver Transpl 6 6 (2000) 671-685
103. Armenti V.T., Radomski S.S., Moritz M.J., et al. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. Clin Transpl (2005) 69-83
104. Christopher V., Al-Chalabi T., Richardson P.D., et al. Pregnancy outcome after liver transplantation: a single-center experience of 71 pregnancies in 45 recipients. Liver Transpl 12 7 (2006) 1138-1143