Porous implants as drug delivery vehicles to augment host tissue integration

FASEB Journal

Volumn 22, Issue 6, 2008, Pages 1684-1693

  Clark, Paul A ^a   Moioli, Eduardo K ^c   Sumner, D Rick ^b   Mao, Jeremy J ^c,d  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b RUSH MEDICAL COLLEGE   (United States)

^c Department of Biomedical Engineering ^*  (United States)

^d NewYork Presbyterian Hospital   (United States)

Author keywords

Controlled release; Osteoblasts; Stem cells; Transforming growth factor , bone morphogenetic proteins; Wound healing

Indexed keywords

PLACEBO; TITANIUM; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL TISSUE; ARTICLE; BONE GROWTH; CELL ISOLATION; CELL LEVEL; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ADSORPTION; DRUG DELIVERY SYSTEM; DRUG RESPONSE; HUMAN; HUMAN CELL; HUMERUS HEAD; IMPLANTATION; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MICROENCAPSULATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; HUMANS; HUMERUS; MESENCHYMAL STEM CELLS; OSSEOINTEGRATION; POROSITY; PROSTHESES AND IMPLANTS; RABBITS; TITANIUM; TRANSFORMING GROWTH FACTOR BETA1;

ORYCTOLAGUS CUNICULUS;

EID: 44949204535     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-094789     Document Type: Article

References (40)

1. Misch, C. E. (1993) Contemporary Implant Dentistry, Mosby, Chicago
2. Albrektsson, T., Branemark, P. I., Hansson, H. A., and Lindstrom, J. (1981) Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop. Scand. 52, 155-170
3. An, Y. H. (2000) Mechanical properties of bone. In Mechanical Testing of Bone and the Bone-implant Interface (An, Y. H., and Draughn, R. A., eds) pp. 41-63, CRC Press, New York
4. Ratner, B. D., Hoffman, A. S., Schoen, F. J., and Lemons, J. E. (1996) Biomaterials Science: An Introduction to Materials in Medicine, Academic Press, New York
5. McCarthy, E. F., and Frassica, F. J. (1998) Pathology of Bone and Joint Disorders, W.B. Saunders Company, Philadelphia
6. McKoy, B. E., An, Y. H., and Friedman, R. J. (2000) Factors affecting the strength of the bone-implant interface. In Mechanical Testing of Bone and the Bone-implant Interface (An, Y. H., and Draughn, R. A., eds) pp. 439-462, CRC Press, New York
7. Ingham, E., and Fisher, J. (2000) Biological reactions to wear debris in total joint replacement. Proc. Inst. Mech. Eng. [H] 214, 21-37
8. Lossdorfer, S., Schwartz, Z., Wang, L., Lohmann, C. H., Turner, J. D., Wieland, M., Cochran, D. L., and Boyan, B. D. (2004) Microrough implant surface topographies increase osteogenesis by reducing osteoclast formation and activity. J. Biomed. Mater. Res. A 70, 361-369
9. Meredith, D. O., Riehle, M. O., Curtis, A. S., and Richards, R. G. (2007) Is surface chemical composition important for orthopaedic implant materials? J. Mater. Sci. Mater. Med. 18, 405- 413
10. Nebe, J. G., Luethen, F., Lange, R., and Beck, U. (2007) Interface interactions of osteoblasts with structured titanium and the correlation between physicochemical characteristics and cell biological parameters. Macromol. Biosci. 7, 567-578
11. Roberts, A. B. (2000) Transforming growth factor-beta In Skeletal Growth Factors (Canalis, E., ed) pp. 233-249, Lippincott, Williams, and Wilkins, Philadelphia
12. Alliston, T. N., and Derynck, R. (2000) Transforming growth factor-β in skeletal development and maintenance. In Skeletal Growth Factors (Canalis, E., ed) pp. 233-249, Lippincott, Williams, and Wilkins, Philadelphia
13. Dimitriou, R., Tsiridis, E., and Giannoudis, P. V. (2005) Current concepts of molecular aspects of bone healing. Injury 36, 1392-1404
14. Zhang, H., Aronow, M. S., and Gronowicz, G. A. (2005) Transforming growth factor-beta 1 (TGF-β1) prevents the age-dependent decrease in bone formation in human osteoblast/implant cultures. J. Biomed. Mater. Res. A 75, 98-105
15. Liu, Y., Enggist, L., Kuffer, A. F., Buser, D., and Hunziker, E. B. (2007) The influence of BMP-2 and its mode of delivery on the osteoconductivity of implant surfaces during the early phase of osseointegration. Biomaterials 28, 2677-2686
16. Sumner, D. R., Turner, T. M., Urban, R. M., Virdi, A. S., and Inoue, N. (2006) Additive enhancement of implant fixation following combined treatment with rhTGF-β2 and rhBMP-2 in a canine model. J. Bone. Joint. Surg. Am. 88, 806-817
17. Zhang, R., An, Y., Toth, C. A., Draughn, R. A., Dimaano, N. M., and Hawkins, M. V. (2004) Osteogenic protein-1 enhances osseointegration of titanium implants coated with peri-apatite in rabbit femoral defect. J. Biomed. Mater. Res. B. Appl. Biomater. 71, 408-413
18. Holland, T. A., Bodde, E. W., Cuijpers, V. M., Baggett, L. S., Tabata, Y., Mikos, A. G., and Jansen, J. A. (2007) Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. Osteoarthritis Cartilage 15, 187-197
19. Moioli, E. K., Hong, L., Guardado, J., Clark, P. A., and Mao, J. J. (2006) Sustained release of TGF-β3 from PLGA microspheres and its effect on early osteogenic differentiation of human mesenchymal stem cells. Tissue Eng. 12, 537-546
20. Moioli, E. K., Clark, P. A., Xin, X., Lal, S., and Mao, J. J. (2007) Matrices and scaffolds for drug delivery in dental, oral and craniofacial tissue engineering. Adv. Drug. Deliv. Rev. 59, 308-324
21. Moioli, E. K., Hong, L., and Mao, J. J. (2007) Inhibition of osteogenic differentiation of human mesenchymal stem cells. Wound Repair Regen. 15, 413-424
22. Cohen, S., Yoshioka, T., Lucarelli, M., Hwang, L. H., and Langer, R. (1991) Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm. Res. 8, 713-720
23. Marion, N. W., and Mao, J. J. (2006) Mesenchymal stem cells and tissue engineering. Methods Enzymol. 420, 339-361
24. Hong, L., Peptan, I., Clark, P., and Mao, J. J. (2005) Ex vivo adipose tissue engineering by human marrow stromal cell seeded gelatin sponge. Ann. Biomed. Eng. 33, 511-517
25. Cory, A. H., Owen, T. C., Barltrop, J. A., and Cory, J. G. (1991) Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun. 3, 207-212
26. Yamamoto, M., Tabata, Y., Hong, L., Miyamoto, S., Hashimoto, N., and Ikada, Y. (2000) Bone regeneration by transforming growth factor β1 released from a biodegradable hydrogel. J. Control. Release 64, 133-142
27. Sumner, D. R., Turner, T. M., and Urban, R. M. (2001) Animal models relevant to cementless joint replacement. J. Musculoskelet. Neuronal Interact. 1, 333-345
28. Lind, M. (1998) Growth factor stimulation of bone healing. Effects on osteoblasts, osteomies, and implants fixation. Acta Orthop. Scand. Suppl. 283, 2-37
29. Sumner, D. R., Turner, T. M., Urban, R. M., Leven, R. M., Hawkins, M., Nichols, E. H., McPherson, J. M., and Galante, J. O. (2001) Locally delivered rhTGF-β2 enhances bone ingrowth and bone regeneration at local and remote sites of skeletal injury. J. Orthop. Res. 19, 85-94
30. Clark, P. A., Rodriguez, A., Sumner, D. R., Hussain, M. A., and Mao, J. J. (2005) Modulation of bone ingrowth of rabbit femur titanium implants by in vivo axial micromechanical loading. J. Appl. Physiol. 98, 1922-1929
31. De Ranieri, A., Virdi, A. S., Kuroda, S., Shott, S., Leven, R. M., Hallab, N. J., and Sumner, D. R. (2005) Local application of rhTGF-β2 enhances peri-implant bone volume and bone-implant contact in a rat model. Bone 37, 55-62
32. Alhadlaq, A., Elisseeff, J. H., Hong, L., Williams, C. G., Caplan, A. I., Sharma, B., Kopher, R. A., Tomkoria, S., Lennon, D. P., Lopez, A., and Mao, J. J. (2004) Adult stem cell driven genesis of human-shaped articular condyle. Ann. Biomed. Eng. 32, 911-923
33. Linkhart, T. A., Mohan, S., and Baylink, D. J. (1996) Growth factors for bone growth and repair: IGF, TGF β and BMP. Bone 19, 1S-12S
34. Doll, B., Sfeir, C., Winn, S., Huard, J., and Hollinger, J. (2001) Critical aspects of tissue-engineered therapy for bone regeneration. Crit. Rev. Eukaryot. Gene. Exp. 11, 173-198
35. Lu, L., Stamatas, G. N., and Mikos, A. G. (2000) Controlled release of transforming growth factor beta1 from biodegradable polymer microparticles. J. Biomed. Mater. Res. 50, 440-451
36. Leach, J. K., and Mooney, D. J. (2004) Bone engineering by controlled delivery of osteoinductive molecules and cells. Expert Opin. Biol. Ther. 4, 1015-1027
37. Schliephake, H., Scharnweber, D., Dard, M., Sewing, A., Aref, A., and Roessler, S. (2005) Functionalization of dental implant surfaces using adhesion molecules. J. Biomed. Mater. Res. B Appl. Biomater. 73, 88-96
38. Alhadlaq, A., and Mao, J. J. (2004) Mesenchymal stem cells: isolation and therapeutics. Stem. Cells. Dev. 13, 436-448
39. Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., and Marshak, D. R. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147
40. Hunziker, E. B., and Rosenberg, L. C. (1996) Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane. J. Bone Joint. Surg. Am. 78, 721-733