Locally delivered rhTGF-β2 enhances bone ingrowth and bone regeneration at local and remote sites of skeletal injury

Journal of Orthopaedic Research

Volumn 19, Issue 1, 2001, Pages 85-94

  Sumner, D R ^a   Turner, T M ^a   Urban, R M ^a   Leven, R M ^a   Hawkins, M ^b   Nichols, E H ^c   McPherson, J M ^c   Galante, J O ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Rush Presbyterian St Luke's Medical Center ^*  (United States)

^c Genzyme Tissue Repair   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; GENETIC ENGINEERING; GROWTH KINETICS; HYDROXYAPATITE; IMPLANTS (SURGICAL);

GAP HEALING;

ORTHOPEDICS;

BUFFER; CALCIUM PHOSPHATE; GROWTH FACTOR; HYDROXYAPATITE; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA2;

ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE GROWTH; BONE INJURY; BONE MATURATION; BONE REGENERATION; CERAMICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DRUG DELIVERY SYSTEM; DRUG RELEASE; HOST; HUMERUS; IMPLANT; IN VITRO STUDY; MALE; NONHUMAN; OSSIFICATION; POROSITY; PRIORITY JOURNAL; STIMULATION; TIME;

ANIMALS; BIOMECHANICS; BONE DEVELOPMENT; BONE REGENERATION; DOGS; HUMERUS; MALE; PROSTHESES AND IMPLANTS; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035067150     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-0266(00)00015-2     Document Type: Article

References (48)

1. Potentiation of transforming growth factor-β by natural coral and fibrin in a rabbit cranioplasty model
2. Removal of tibial marrow induces increased formation of bone and cartilage in rat mandibular condyle
3. Regulatory role of osteogenic growth peptide in proliferation, osteogenesis, and hemopoiesis
4. Polypeptide factors regulating osteogenesis and bone marrow repair
5. 1
6. 1 induces bone closure of skull defects
7. One systematic administration of transforming growth factor-β1 reverses age- or glucocorticoid-impaired wound healing
8. Histomorphometric assessment of the mechanisms for rapid ingrowth of bone to HA/TCP coated implants
9. Parathyroid hormone modulates transforming growth factor β activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone
10. Transforming growth fator-β gene family members, their receptors, and cell function
11. Enhanced ingrowth of porous-coated CoCr implants plasma-sprayed with tricalcium phosphate
12. Improving the accuracy of trabecular width measurements
13. Hepatic processing of transfroming growth factor β in the rat: Uptake, metabolism, and biliary excretion
14. Hydroxylapatite coating of porous implants improves bone ingrowth and interface attachment strength
15. The effect of operative fit and hydroxyapatite coating on the mechanical and biological response to porous implants
16. Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutilization and transforming growth factor beta 2 affinity purification
17. The osteogenic response to distant skeletal injury
18. Regenerating marrow induces systematic increase on osteo-and chondrogenesis
19. Recombinat TGF-betal stimulates bone marrow osteoprogenitor cell activity and bone matrix synthesis in osteopenic, old male mice
20. 1 released from polymeric or ceramic implants
21. 1 from a biodegradable matrix for bone regeneration
22. Transforming growth factor-β stimulates bone matrix apposition and bone cell replication in cultured fetal calvariae
23. Ilizarov callus distraction produces sytematic bone cell mitogens
24. Human transforming growth factor type beta 2: Production by a prostatic adenocarcinoma cell line, purification and initial characterization
25. Retrieval: Successful uncemented implants
26. Transforming growth factor-beta accelerates osteoinduction in a craniofacial onlay model
27. Implant fixation by bone ingrowth
28. Efficacy of autograft and freeze-dried allograft to enhance fixation of porous-coated implants in the presence of interface gaps
29. Chemotaxis of human osteoblasts. Effects of osteotropic growth factors
30. Transforming growth factor-β stimulates bone ongrowth: Hydroxyapatie-coated implants studied in dogs
31. Transforming growth factor-β1 stimulates bone ongrowth to weight-loaded tricalcium phosphate coated implants
32. Transforming growth factor-β1 enhances bone healing to unloaded tricalcium phosphate coated implants: An experimental study in dogs
33. Transforming growth factor-beta enhances fracture healing in rabbit tibiae
34. Systemic administration of transforming growth factor-β2 prevents the impaired bone formation and osteopenia induced by unloading in rats
35. A sytematic accelatory phenomenon (SAP) accompanies the regional accelaratory phenomenon (RAP) during healing of a bone defect in the rat
36. In vitro release kinetics of biologically active transforming growth factor-β1 from a novel porous glass carrier
37. Local injection of TGF-β increases the strength of tibial fractures in the rat
38. 2 on vertebral trabecular remodelling in beagles used in a healing study
39. Development of tricalcium phosphate/amylopectin paste combined with recombinant human transforming growth factor beta 1 as a bone defect filler
40. Calcium phosphate-coated porous titanium implants for enhanced skeletal fixation
41. Osteoblasts synthesize and respond to transforming growth factor-type β (TGF-β) in vitro
42. Tissue ingrowth into titanium and hydroxyapatite-coated implants during stable and unstable mechanical conditions
43. Bone ingrowth
44. Metallic implants
45. Enhancement of bone ingrowth by transforming growth factor beta
46. Animal models of bone ingrowth and joint replacement
47. 1 and L-ascorbate on synthesis and distribution of proteoglycans in murine osteoblast-like cells
48. 1 after topical and intravenous administration in male rats