-
1
-
-
4344577023
-
Electrophysiologic effects of ranolazine, a novel antianginal agent with antiarrhythmic properties
-
Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Thomas G. Electrophysiologic effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110: 904-910, 2004.
-
(2004)
Circulation
, vol.110
, pp. 904-910
-
-
Antzelevitch, C.1
Belardinelli, L.2
Zygmunt, A.C.3
Burashnikov, A.4
Di Diego, J.M.5
Fish, J.M.6
Cordeiro, J.M.7
Thomas, G.8
-
2
-
-
33745368556
-
Inhibition of the late sodium current as a potential cardioprotective principle: Effects of the late sodium current inhibitor ranolazine
-
Belardinelli L, Shryock JC, Fraser H. Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine. Heart 96: 6-14, 2006.
-
(2006)
Heart
, vol.96
, pp. 6-14
-
-
Belardinelli, L.1
Shryock, J.C.2
Fraser, H.3
-
3
-
-
0025938657
-
Pharmacological evaluation of early afterdepolarisations induced by sea anemone toxin (ATXII) in dog heart
-
Boutjdir M, El-Sherif N. Pharmacological evaluation of early afterdepolarisations induced by sea anemone toxin (ATXII) in dog heart. Cardiovasc Res 25: 815-819, 1991.
-
(1991)
Cardiovasc Res
, vol.25
, pp. 815-819
-
-
Boutjdir, M.1
El-Sherif, N.2
-
4
-
-
34748873780
-
Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation
-
Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation. Circulation 116: 1449-1457, 2007.
-
(2007)
Circulation
, vol.116
, pp. 1449-1457
-
-
Burashnikov, A.1
Di Diego, J.M.2
Zygmunt, A.C.3
Belardinelli, L.4
Antzelevitch, C.5
-
5
-
-
0348129532
-
Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: A randomized controlled trial
-
Chaitman BR, Pepine CJ, Parker JO, Skopal J, Chumakova G, Kuch J, Wang W, Skettino SL, Wolff AA. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA 291: 309-316, 2004.
-
(2004)
JAMA
, vol.291
, pp. 309-316
-
-
Chaitman, B.R.1
Pepine, C.J.2
Parker, J.O.3
Skopal, J.4
Chumakova, G.5
Kuch, J.6
Wang, W.7
Skettino, S.L.8
Wolff, A.A.9
-
6
-
-
11144356285
-
Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina
-
Chaitman BR, Skettino SL, Parker JO, Hanley P, Meluzin J, Kuch J, Pepine CJ, Wang W, Nelson JJ, Herbert DA, Wolff AA. Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina. J Am Coll Cardiol 43: 1375-1382, 2004.
-
(2004)
J Am Coll Cardiol
, vol.43
, pp. 1375-1382
-
-
Chaitman, B.R.1
Skettino, S.L.2
Parker, J.O.3
Hanley, P.4
Meluzin, J.5
Kuch, J.6
Pepine, C.J.7
Wang, W.8
Nelson, J.J.9
Herbert, D.A.10
Wolff, A.A.11
-
7
-
-
0036707486
-
2+ triggers early afterdepolarizations and Torsades de Pointes in rabbit hearts with type 2 long QT syndrome
-
2+ triggers early afterdepolarizations and Torsades de Pointes in rabbit hearts with type 2 long QT syndrome. J Physiol 543: 615-631, 2002.
-
(2002)
J Physiol
, vol.543
, pp. 615-631
-
-
Choi, B.R.1
Burton, F.2
Salama, G.3
-
8
-
-
33646386662
-
Molecular basis of ranolazine block of LQT-3 mutant sodium channels: Evidence for site of action
-
Fredj S, Sampson KJ, Liu H, Kass RS. Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action. Br J Pharmacol 148: 16-24, 2006.
-
(2006)
Br J Pharmacol
, vol.148
, pp. 16-24
-
-
Fredj, S.1
Sampson, K.J.2
Liu, H.3
Kass, R.S.4
-
9
-
-
4043127405
-
2+-activated non-selective cation channel in human atrial cardiomyocytes
-
2+-activated non-selective cation channel in human atrial cardiomyocytes. J Physiol 558: 75-83, 2004.
-
(2004)
J Physiol
, vol.558
, pp. 75-83
-
-
Guinamard, R.1
Chatelier, A.2
Demion, M.3
Potreau, D.4
Patri, S.5
Rahmati, M.6
Bois, P.7
-
10
-
-
0021646404
-
The effects of the Anemonia sulcata toxin (ATX-II) on membrane currents of isolated mammalian myocytes
-
Isenberg G, Raven U. The effects of the Anemonia sulcata toxin (ATX-II) on membrane currents of isolated mammalian myocytes. J Physiol 357: 127-149, 1984.
-
(1984)
J Physiol
, vol.357
, pp. 127-149
-
-
Isenberg, G.1
Raven, U.2
-
12
-
-
0029952835
-
Hypoxia increases persistent sodium current in rat ventricular myocytes
-
Ju YK, Saint DA, Gage PW. Hypoxia increases persistent sodium current in rat ventricular myocytes. J Physiol 497: 337-347, 1996.
-
(1996)
J Physiol
, vol.497
, pp. 337-347
-
-
Ju, Y.K.1
Saint, D.A.2
Gage, P.W.3
-
13
-
-
0022968995
-
Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle
-
Marban E, Robinson SW, Wier WG. Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J Clin Invest 78: 1185-1192, 1986.
-
(1986)
J Clin Invest
, vol.78
, pp. 1185-1192
-
-
Marban, E.1
Robinson, S.W.2
Wier, W.G.3
-
14
-
-
34247526904
-
Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes; the MERLIN-TIMI 36 randomized trial
-
Morrow D, Scirica BM, Karwatowska-Prokopezuk E, Murphy SA, Budaj A, Varshavsky S, Wolff AA, Skene A, McCabe CH, Braunwald E. Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes; the MERLIN-TIMI 36 randomized trial. JAMA 297: 1775-1783, 2007.
-
(2007)
JAMA
, vol.297
, pp. 1775-1783
-
-
Morrow, D.1
Scirica, B.M.2
Karwatowska-Prokopezuk, E.3
Murphy, S.A.4
Budaj, A.5
Varshavsky, S.6
Wolff, A.A.7
Skene, A.8
McCabe, C.H.9
Braunwald, E.10
-
15
-
-
33745424116
-
Computer model of electrophysiological instability in very small heterogeneous ventricular syncytia
-
Nordin C. Computer model of electrophysiological instability in very small heterogeneous ventricular syncytia. Am J Physiol Heart Circ Physiol 272: H1838-H1856, 1997.
-
(1997)
Am J Physiol Heart Circ Physiol
, vol.272
-
-
Nordin, C.1
-
16
-
-
0029062403
-
Computer model of current-induced early afterdepolarizations in guinea pig ventricular myocytes
-
Nordin C, Ming Z. Computer model of current-induced early afterdepolarizations in guinea pig ventricular myocytes. Am J Physiol Heart Circ Physiol 268: H2440-H2459, 1995.
-
(1995)
Am J Physiol Heart Circ Physiol
, vol.268
-
-
Nordin, C.1
Ming, Z.2
-
18
-
-
4444302203
-
Ranolazine: Ion-channel-blocking actions and in vivo electrophysiological effects
-
Schram G, Zhang L, Derakhchan K, Ehrlich JR, Belardinelli L, Nattel S. Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects. Br J Pharmacol 142: 1300-1308, 2004.
-
(2004)
Br J Pharmacol
, vol.142
, pp. 1300-1308
-
-
Schram, G.1
Zhang, L.2
Derakhchan, K.3
Ehrlich, J.R.4
Belardinelli, L.5
Nattel, S.6
-
19
-
-
0023662987
-
A mechanistic interpretation of the action of toxin II from Anemonia sulcata on the cardiac sodium channel
-
Schreibmayer W, Kazerani H, Tritthart HA. A mechanistic interpretation of the action of toxin II from Anemonia sulcata on the cardiac sodium channel. Biochim Biophys Acta 901: 273-282, 1987.
-
(1987)
Biochim Biophys Acta
, vol.901
, pp. 273-282
-
-
Schreibmayer, W.1
Kazerani, H.2
Tritthart, H.A.3
-
20
-
-
35148850168
-
-
Scirica BM, Morrow DA, Hod H, Murphy SA, Belardinelli L, Hedgepeth CM, Molhoek P, Verheugt FW, Gersh BJ, McCabe CH, Braunwald E. Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial. Circulation 116: 1647-1652, 2007.
-
Scirica BM, Morrow DA, Hod H, Murphy SA, Belardinelli L, Hedgepeth CM, Molhoek P, Verheugt FW, Gersh BJ, McCabe CH, Braunwald E. Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial. Circulation 116: 1647-1652, 2007.
-
-
-
-
21
-
-
44949176560
-
An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes
-
Heart Circ Physiol February 29, doi: 10.1152/ajpheart.00285
-
Song Y, Shryock JC, Belardinelli L. An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes. Am J Physiol Heart Circ Physiol (February 29, 2008); doi: 10.1152/ajpheart.00285.2008.
-
(2008)
Am J Physiol
-
-
Song, Y.1
Shryock, J.C.2
Belardinelli, L.3
-
23
-
-
33746192571
-
Antianginal efficacy of ranolazine when added to treatment with amlodipine: The ERICA (Efficacy of Ranolazine in Chronic Angina) trial
-
Stone PH, Gratsiansky NA, Blokhim A, Huang IZ, Meng L. Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial. J Am Coll Cardiol 48: 566-575, 2006.
-
(2006)
J Am Coll Cardiol
, vol.48
, pp. 566-575
-
-
Stone, P.H.1
Gratsiansky, N.A.2
Blokhim, A.3
Huang, I.Z.4
Meng, L.5
-
24
-
-
0035143074
-
Differences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndrome
-
Studenik CR, Zhou Z, January CT. Differences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndrome. Br J Pharmacol 132: 85-92, 2001.
-
(2001)
Br J Pharmacol
, vol.132
, pp. 85-92
-
-
Studenik, C.R.1
Zhou, Z.2
January, C.T.3
-
26
-
-
0032898049
-
Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: Role of sustained inward current
-
Undrovinas AI, Maltsev VA, Sabbah HN. Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: role of sustained inward current. Cell Mol Life Sci 55: 494-505, 1999.
-
(1999)
Cell Mol Life Sci
, vol.55
, pp. 494-505
-
-
Undrovinas, A.I.1
Maltsev, V.A.2
Sabbah, H.N.3
-
27
-
-
33646007982
-
Ranolazine improves abnormal repolarization, and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current
-
Undrovinas AI. Ranolazine improves abnormal repolarization, and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current. J Cardiovasc Electrophysiol 17: 161-177, 2006.
-
(2006)
J Cardiovasc Electrophysiol
, vol.17
, pp. 161-177
-
-
Undrovinas, A.I.1
-
28
-
-
14744290314
-
Increased late sodium current in myocytes from a canine heart failure model and from failing human hearts
-
Valdivia CR, Chu WW, Pu JL, Foell JD, Haworth RA, Wolff MR, Kamp TJ, Makielski JC. Increased late sodium current in myocytes from a canine heart failure model and from failing human hearts. J Mol Cell Cardiol 38: 475-483, 2005.
-
(2005)
J Mol Cell Cardiol
, vol.38
, pp. 475-483
-
-
Valdivia, C.R.1
Chu, W.W.2
Pu, J.L.3
Foell, J.D.4
Haworth, R.A.5
Wolff, M.R.6
Kamp, T.J.7
Makielski, J.C.8
-
29
-
-
3342882854
-
Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome
-
Wu L, Shryock JC, Song Y, Li Y, Antzelevitch C, Belardinelli L. Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome. J Pharmacol Exp Ther 310: 599-605, 2004.
-
(2004)
J Pharmacol Exp Ther
, vol.310
, pp. 599-605
-
-
Wu, L.1
Shryock, J.C.2
Song, Y.3
Li, Y.4
Antzelevitch, C.5
Belardinelli, L.6
-
30
-
-
0028911903
-
Early afterdepolarizations in cardiac myocytes: Mechanism and rate dependence
-
Zeng J, Rudy Y. Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophys J 68: 949-964, 1995.
-
(1995)
Biophys J
, vol.68
, pp. 949-964
-
-
Zeng, J.1
Rudy, Y.2
|