Thrombomodulin: From haemostasis to inflammation and tumourigenesis

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 9, 2008, Pages 1669-1673

  Koutsi, Aikaterini ^a   Papapanagiotou, Angeliki ^a   Papavassiliou, Athanasios G ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Embryogenesis; Haemostasis; Inflammation; Thrombomodulin; Tumour growth

Indexed keywords

COMPLEMENTARY DNA; THROMBOMODULIN;

AMINO TERMINAL SEQUENCE; BETA SHEET; CARCINOGENESIS; EMBRYO DEVELOPMENT; HUMAN; INFLAMMATION; MALIGNANT NEOPLASTIC DISEASE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; SHORT SURVEY;

ANIMALS; GENE EXPRESSION REGULATION; HEMOSTASIS; HUMANS; INFLAMMATION; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOMODULIN;

EID: 44949090483     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2007.06.024     Document Type: Short Survey

References (30)

1. Bajzar L., Manuel R., and Nesheim M.E. Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor. J. Biol. Chem. 270 (1995) 14477-14484
2. Calnek D.S., and Grinnell B.W. Thrombomodulin-dependent anticoagulant activity is regulated by vascular endothelial growth factor. Exp. Cell Res. 238 (1998) 294-298
3. Campbell W.D., Lazoura E., Okada N., and Okada H. Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. Microbiol. Immunol. 46 (2002) 131-134
4. Collins C.L., Ordonez N.G., Schaefer R., Cook C.D., Xie S.S., Grander J., Hsu P.L., Fink L., and Hsu S.M. Thrombomodulin expression in malignant pleural mesothelioma and pulmonary adenocarcinoma. Am. J. Pathol. 141 (1992) 827-833
5. Conway E.M., Pollefeyt S., Collen D., and Steiner-Mosonyi M. The amino terminal lectin-like domain of thrombomodulin is required for constitutive endocytosis. Blood 89 (1997) 652-661
6. Conway E.M., and Rosenberg R.D. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol. Cell. Biol. 8 (1988) 5588-5592
7. Coughlin S.R. Thrombin signalling and protease-activated receptors. Nature 407 (2000) 258-264
8. 2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II. J. Biol. Chem. 280 (2005) 35999-36006
9. de Munk G.A., Parkinson J.F., Groeneveld E., Bang N.U., and Rijken D.C. Role of the glycosaminoglycan component of thrombomodulin in its acceleration of the inactivation of single-chain urokinase-type plasminogen activator by thombin. Biochem. J. 290 (1993) 655-659
10. Esmon C.T. The roles of protein C and thrombomodulin in the regulation of blood coagulation. J. Biol. Chem. 264 (1989) 4743-4746
11. Grey S.T., and Hancock W.W. A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes. J. Immunol. 156 (1996) 2256-2263
12. Hrabal R., Komives E.A., and Ni F. Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin. Protein Sci. 5 (1996) 195-203
13. Jackman R.W., Beeler D.L., Fritze L., Soff G., and Rosenberg R.D. Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control. Proc. Natl. Acad. Sci. USA 84 (1987) 6425-6429
14. Kim S.J., Shiba E., Ishii H., Inoue T., Tagushi T., Tanji Y., Kimoto Y., Izukuma M., and Takai S. Thrombomodulin, a new biological and prognostic marker for beast cancer: an immunohistochemical study. Anticancer Res. 17 (1997) 2319-2329
15. Koyama T., Parkinson J.F., Sié P., Bang N.U., Muller-Berghaus G., and Preissner K.T. Different glycoforms of human thrombomodulin. Their glycosaminoglycan-dependent modulatory effects on thrombin inactivation by heparin cofactor II and antithrombin III. Eur. J. Biochem. 198 (1991) 563-570
16. 2+. Eur. J. Biochem. 262 (1999) 522-533
17. Riewald M., and Ruf W. Orchestration of coagulation protease signaling by tissue factor. Trends Cardiovasc. Med. 12 (2002) 149-154
18. Riewald M., Petrovan R.J., Donner A., Mueller B.M., and Ruf W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296 (2002) 1880-1882
19. Rosenberg R.D., and Lam L.H. Correlation between structure and function of heparin. Proc. Natl. Acad. Sci. USA 76 (1979) 1218-1222
20. Shi J., Wang J., Zheng H., Ling W., Joseph J., Li D., Mehta J.L., Ponnappan U., Lin P., Fink L.M., and Hauer-Jensen M. Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin down regulation. Blood Coagul. Fibrinol. 14 (2003) 575-585
21. Sohn R.H., Deming C.B., Johns D.C., Champion H.C., Bian C., Gardner K., and Rade J.J. Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappaB. Blood 105 (2005) 3910-3917
22. Sperry J.L., Deming C.B., Bian C., Walinsky P.L., Kass D.A., Kolodgie F.D., Virmani R., Kim A.Y., and Rade J.J. Wall tension is a potent negative regulator of in vivo thrombomodulin expression. Circ. Res. 92 (2003) 41-47
23. Srinivasan J., Hu S., Hrabal R., Zhu Y., Komives E.A., and Ni F. Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear Overhauser effects. Biochemistry 33 (1994) 13553-13560
24. Stephens A.W., Siddiqui A., and Hirs C.H.W. Site directed mutagenesis of the reactive center (serine 394) of antithrombin III. J. Biol. Chem. 263 (1988) 15849-15852
25. Suzuki K., Kusomoto H., Deyashiki Y., Hishioka J., Maruyama I., Zushi M., Kowahora S., Honda G., Yamamoto S., and Horigushi S. Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. EMBO J. 6 (1987) 1891-1897
26. von der Ahe D., Nischan C., and Kunz C. Ets transcription factor binding site is required for positive and TNF-alpha induced negative promoter regulation. Nucleic Acids Res. 21 (1993) 5636-5643
27. Waugh J.M., Li-Hawkins J., Yuksel E., Kuo M.D., Cifra P.N., Hilfiker P.R., Geske R., Chawla M., Thomas J., Shenaq S.M., Dake M.D., and Woo S.L. Thrombomodulin overexpression to limit neointima formation. Circulation 102 (2000) 332-337
28. Weiler H., Aird W.C., Rayburn H., Husain M., and Rosenberg R.D. Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos. Development 122 (1996) 2271-2281
29. Weiler H., and Isermann B.H. Thrombomodulin. J. Thromb. Haemost. 1 (2003) 1515-1524
30. Wong H.R., Ryan M., and Wispe J.R. Stress response decreases NF-kappaB nuclear translocation and increases I-kappaBalpha expression in A549 cells. J. Clin. Invest. 99 (1997) 2423-2428