Aldose Reductase Inhibition in Diabetic Neuropathy: Clinical and Neurophysiological Studies of one Year's Treatment with Sorbinil

Diabetic Medicine

Volumn 5, Issue 6, 1988, Pages 537-542

  O'Hare, J P ^a   Morgan, M H ^a   Alden, P ^a   Chissel, S ^a   O'Brien, I A D ^a   Corrall, R J M ^a  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Aldose reductase inhibition; Diabetes; Neuropathy; Sorbinil

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; GLYCOSYLATED HEMOGLOBIN; SORBINIL;

CONTROLLED STUDY; DIABETIC NEUROPATHY; FEMALE; HEART RATE; HUMAN; MALE; NERVE CONDUCTION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ALDEHYDE REDUCTASE; BLOOD GLUCOSE; CLINICAL TRIALS; COMPARATIVE STUDY; DIABETIC NEUROPATHIES; DIABETIC RETINOPATHY; DOUBLE-BLIND METHOD; FEMALE; HEART RATE; HUMAN; IMIDAZOLES; MALE; MEDIAN NERVE; MIDDLE AGE; NEURAL CONDUCTION; PERONEAL NERVE; RANDOM ALLOCATION; SUGAR ALCOHOL DEHYDROGENASES; SUPPORT, NON-U.S. GOV'T; VALSALVA'S MANEUVER;

EID: 0023774175     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.1988.tb01047.x     Document Type: Article

References (23)

1. Diabetes mellitus and its degenerative complications: A prospective study of 4400 patients observed between 1947 and 1973
2. Diabetic autonomic neuropathy
3. The natural history of diabetic autonomic neuropathy
4. Nerve conduction abnormalities in untreated maturity‐onset diabetes: relation to levels of fasting plasma glucose and glycosylated haemoglobin
5. Role of the sorbitol pathway in neuropathy
6. The biochemistry of the complications of diabetes mellitus
7. Diabetic neuropathy. New concepts of its aetiology
8. The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats
9. CP‐45, 634: A novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosaemic rats
10. Myoinositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition
11. Aldose reductase inhibition improves nerve conduction velocity in diabetic patients
12. A controlled study of sorbinil, an aldose reductase inhibitor, in chronic painful diabetic neuropathy
13. Treatment of severely painful diabetic neuropathy with an aldose reductase inhibitor; relief of pain and improved somatic and autonomic nerve function
14. Clinical and neurophysiological studies with the aldose reductase inhibitor sorbinil in symptomatic diabetic neuropathy
15. Quantitative determination of glycosylated haemoglobin A, by agar gel electrophoresis
16. Cardiovascular autonomic function testing: an automated method for measuring heart rate variation
17. Comparison of clinical course and sequential electrophysiological tests in diabetes with symptomatic polyneuropathy and its implications for clinical trials
18. The effect of sorbinil treatment on red cell sorbitol levels and clinical and electrophysiological parameters of diabetic neuropathy
19. Myoinositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment
20. Platelet abnormalities in diabetic peripheral neuropathy
21. Abnormal platelet aggregation in chronic symptomatic diabetic peripheral neuropathy
22. Steno Study Group. Two‐year experience with continuous insulin infusion in relationship to retinopathy and neuropathy
23. Effect of near normoglycaemia for two years on progression of early diabetic retinopathy, nephropathy and neuropathy: the Oslo study