Chlorhexidine with an anti discoloration system after periodontal flap surgery: A cross-over, randomized, triple-blind clinical trial

Journal of Clinical Periodontology

Volumn 35, Issue 7, 2008, Pages 614-620

  Cortellini, Pierpaolo ^a,b,e   Labriola, Antonella ^c   Zambelli, Raffaella ^c   Pini Prato, Giovanpaolo ^d   Nieri, Michele ^d   Tonetti, Maurizio S ^c  

^a Accademia Toscana di Ricerca Odontostomatologica   (Italy)

^b European Research Group on Periodontology ERGOPerio   (Switzerland)

^c Private Practice   (Italy)

^d UNIVERSITY OF FLORENCE   (Italy)

^e NONE   (Italy)

Author keywords

Chlorhexidine; Mouthrinses; Periodontal surgery; Post surgical protocols; Staining

Indexed keywords

ASCORBIC ACID; CHLORHEXIDINE; SODIUM METABISULFITE; SULFITE; TOPICAL ANTIINFECTIVE AGENT;

ADULT; AGED; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GINGIVA; HUMAN; MALE; MIDDLE AGED; MOUTHWASH; PATIENT COMPLIANCE; PERIODONTITIS; PLASTIC SURGERY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL; TASTE; TOOTH DISCOLORATION; TOOTH PLAQUE; TREATMENT OUTCOME; WOUND HEALING;

ADULT; AGED; ANTI-INFECTIVE AGENTS, LOCAL; ASCORBIC ACID; CHLORHEXIDINE; CROSS-OVER STUDIES; DENTAL PLAQUE; DOUBLE-BLIND METHOD; FEMALE; GINGIVA; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; MOUTHWASHES; PATIENT COMPLIANCE; PERIODONTITIS; SULFITES; SURGICAL FLAPS; TASTE; TOOTH DISCOLORATION; TREATMENT OUTCOME; WOUND HEALING;

EID: 44849142831     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2008.01238.x     Document Type: Article

References (29)

1. Addy, M. (1986) Chlorhexidine compared to other locally derived antimicrobials. Journal of Clinical Periodontology 13, 957 964.
2. Addy, M. (2003) The use of antiseptics in periodontal therapy. Chapter 22. In : Lindhe J., Karring, T. Lang, N. P. (eds). Clinical Periodontology and Implant Dentistry, 4th edition. pp. 464 493. U.K. : Blackwell Munksgaard.
3. Addy, M., Moran, J., Griffiths, A. A. Wills-Wood, N. J. (1985) Extrinsic tooth discoloration by metals and chlorhexidine I. Surface protein denaturation or dietary precipitation? British Dental Journal 159, 281 285.
4. Addy, M. Renton-Harper, P. (1996) Local and systemic chemotherapy in the management of periodontal disease: an opinion and review of the concept. Journal of Oral Rehabilitation 23, 219 231.
5. Addy, M., Sharif, N. Moran, J. (2005) A non-staining chlorhexidine mouthwash? Probably not: a study in vitro. International Journal of Dental Hygiene 3, 59 63.
6. Arweiler, N. B., Boehnke, N., Sculean, A., Hellwig, E. Auschill, T. M. (2006) Differences in efficacy of two commercial 0.2% chlorhexidine mouthrinse solutions: a 4 day plaque re-growth study. Journal of Clinical Periodontology 33, 334 339.
7. Bernardi, F., Pincelli, M. R., Carloni, S., Gatto, M. R. Montebugnoli, L. (2004) Chlorhexidine with anti discoloration system. A comparative study. International Journal of Dental Hygiene 2, 122 126.
8. Claydon, N., Addy, M., Jackson, R., Smith, S. Newcombe, R. G. (2001) Studies on the effect of polyvinyl pirrolidone on the activity of chlorhexidine mouthrinses: plaque and stain. Journal of Clinical Periodontology 28, 558 564.
9. Cortellini, P., Tonetti, M. S., Lang, N. P., Suvan, J. E., Zucchelli, G., Vangsted, T., Silvestri, M., Rossi, R., McClain, P., Fonzar, A., Dubravec, D. Adriaens, P. (2001) The simplified papilla preservation flap in the regenerative treatment of deep intrabony defects: clinical outcomes and postoperative morbidity. Journal of Periodontology 72, 1702 1712.
10. Davies, A. (1973) The mode of action of chlorexidine, 8, 68 75.
11. Dupont, W. D. Plummer, W. D. (1990) Power and sample size calculations: a review and computer program. Controlled Clinical Trials 11, 116 128.
12. Eriksen, H. M., Nardbo, H., Kanteanen, H. Ellingsen, J. E. (1985) Chemical plaque control and extrinsic tooth discoloration. A review of possible mechanism. Journal of Clinical Periodontology 12, 345 350.
13. Faveri, M., Gursky, L. C., Feres, M., Shibli, J. A., Salvador, S. L. de Figueiredo, L. C. (2006) Scaling and root planing and chlorhexidine mouthrinses in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. Journal of Clinical Periodontology 33, 819 828.
14. Gründemann, L. J., Timmarman, M. F., Ijserman, Y., Ven der Velden, U. Ven der Weijden, G. A. (2000) Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate. Journal of Clinical Periodontology 27, 9 15.
15. Goldstein, H. (1995) Multilevel Statistical Models, 2nd edition. London : Edward Arnold, pp. 97 112.
16. Guarnelli, M. E., Zangari, F., Manfrini, R., Scapoli, C. Trombelli, L. (2004) Evaluation of additional amine fluoride/stannous fluoride-containing mouthrinse during supportive therapy in patients with generalized aggressive periodontitis. A randomized, crossover, double blind, controlled trial. Journal of Clinical Periodontology 31, 742 748.
17. Hugo, W. B. Longworth, A. R. (1964) Some aspects of the mode of action of chlorhexidine. Journal of Pharmacy and Pharmacology 16, 655 662.
18. Hugo, W. B. Longworth, A. R. (1965) Cytological aspectsof the mode of action of chlorhexidine diacetate. Journal of Pharmacy and Pharmacology 17, 28 32.
19. Hugo, W. B. Longworth, A. R. (1966) The effects of chlorhexidine on the electrophoretic mobility, cytoplasmatic constituents, dehydrogenase activity and cell walls of Escherichia coli and Staphylococcus aureus. Journal of Pharmacy and Pharmacology 18, 569 578.
20. Jones, C. G. (1997) Chlorexidine: is still the gold standard? Periodontology 2000 15, 55 62.
21. Lang, N. P. Brecx, M. C. (1986) Chlorhexidine diguclonate an agent for chemical plaque control and prevention of gingival inflammation. Journal of Periodontal Research 21 (Suppl.), 74 89.
22. Leard, A. Addy, M. (1997) The propensity of different brands of tea and coffee to cause staining associated to chlorhexidine. Journal of Clinical Periodontology 24, 115 118.
23. Lobene, R. R. (1968) Effect of dentifrices on tooth stains with controlled brushing. Journal of American Dental Association 77, 849 855.
24. Loe, H. Schiott, C. R. (1970) The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in men. Journal of Periodontal Research 5, 79 83.
25. Newman, M. G., Sanz, M., Nachnani, S., Saltini, C. Anderson, L. (1989) Effect of 0.12% chlorhexidine on bacterial recolonisation following periodontal surgery. Journal of Periodontology 60, 577 581.
26. Quirynen, M., Bollen, C. M., Vandekerckhove, B. N., Dekeyser, C., Papaioannou, W. Eyssen, H. (1995) Full- vs. partial-mouth disinfection in the treatment of periodontal infections: short-term clinical and microbiological observations. Journal of Dental Research 74, 1459 1467.
27. Quirynen, M., Teughels, W., De Soete, M. van Steenberghe, D. (2002) Topical antiseptics and antibiotics in the initial therapy of chronic adult periodontitis: microbiological aspects. Periodontology 2000 28, 72 90.
28. Sanz, M., Newman, M. G., Anderson, L., Matoska, W., Otomo-Corgel, J. Saltini, C. (1989) Clinical enhancement of post-periodontal surgical therapy by a 0.12% chlorhexidine gluconate mouthrinse. Journal of Periodontology 60, 570 576.
29. Tonetti, M. S., Fourmousis, I., Suvan, J., Cortellini, P., Bragger, U. Lang, N. P. On behalf of the European Group on Periodontology (ERGOPERIO) (2004) Healing, post-operative morbidity and patient perception of outcomes following regenerative therapy of deep intrabony defects. Journal of Clinical Periodontology 31, 1092 1098.