Local and systemic chemotherapy in the management of periodontal disease: An opinion and review of the concept

Journal of Oral Rehabilitation

Volumn 23, Issue 4, 1996, Pages 219-231

  Addy, M ^a   Renton Harper, P ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; TOPICAL ANTIINFECTIVE AGENT;

ADULT; BACTERIAL INFECTION; CHEMOPROPHYLAXIS; CHRONIC DISEASE; DISEASE PREDISPOSITION; DRUG DELIVERY SYSTEM; HUMAN; MICROBIOLOGY; MOUTH HYGIENE; PERIODONTAL DISEASE; PERIODONTITIS; PREVENTIVE DENTISTRY; RECURRENT DISEASE; REVIEW; TOOTH PLAQUE;

ADULT; ANTI-INFECTIVE AGENTS, LOCAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BACTERIAL INFECTIONS; CHEMOPREVENTION; CHRONIC DISEASE; DENTAL PLAQUE; DENTAL PROPHYLAXIS; DISEASE SUSCEPTIBILITY; DRUG DELIVERY SYSTEMS; HUMANS; ORAL HYGIENE; PERIODONTAL DISEASES; PERIODONTITIS; RECURRENCE;

EID: 0030122285     PISSN: 0305182X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2842.1996.tb00845.x     Document Type: Review

References (101)

1. ABU-FANAS, S.H., DRUCKER, D.B. & HULL, P.S. (1991) Evaluation of acrylic strips containing amoxycillin with clavulanic acid for local drug delivery. Journal of Dentistry, 19, 92.
2. ADDY, M., DUMMER, P.M.H., GRIFFITHS, G., HICKS, R., KINGDON, A. & SHAW, W.C. (1986) Prevalence of plaque, gingivitis, and caries in 11-12 year old children in South Wales. Community Dentistry and Oral Epidemiology, 14, 115.
3. ADDY, M. (1986) Chlorhexidine compared with other locally delivered anti-microbials. A short review. Journal of Clinical Periodontology, 13, 957.
4. ADDY, M., SLAYNE, M.A. & WADE, W.G. (1992) The formation and control of dental plaque - an overview. Journal of Applied Bacteriology, 73, 269.
5. ADDY, M., MORAN, J. & WADE, W. (1994) Chemical plaque control in the prevention of gingivitis and periodontitis. In: Proceedings of the 1st European Workshop on Periodontology (eds N.P. Lang & T. Karring), p. 244. Quintessence Publishing, London.
6. ADDY, M. (1994) Local delivery of antimicrobial agents to the oral cavity. Advanced Drug Delivery Reviews, 13, 123.
7. ADDY, M., RAWLE, L., HANDLEY, R., NEWMAN, H.N. & COVENTRY, J.F. (1982) The development and in vitro evaluation of acrylic strips and dialysis tubing for local drug delivery. Journal of Periodontology, 53, 693.
8. ADDY, M. & LANGEROUDI, M. (1983) Comparison of the immediate effects on the subgingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline. Journal of Clinical Periodontology, 10, 69.
9. ADDY, M., HASSAN, H., MORAN, J., WADE, W. & NEWCOMBE, R. (1988) A 3 month follow up study of antimicrobial containing acrylic strips used in the treatment of chronic periodontal disease. Journal of Periodontology, 59, 557.
10. ADRIAENS, P.A., DEBOEVER, J.A. & LOESCHE, W.J. (1988) Bacterial invasion in root, cementum and radicular dentine of periodontally diseased teeth in humans - a Resevoir of Periodontopathic bacteria. Journal of Periodontology, 59, 222.
11. AINAMO, J. & ETEMADZADEH, H. (1987) Prevention of plaque growth with chewing gum containing chlorhexidine acetate. Journal of Clinical Periodontology, 14, 524.
12. ATTSTROM, R. & VAN DER VELDEN, U. (1994) Consensus report of session I. In: Proceedings of the 1st European Workshop on Periodontology (eds N.P. Lang, & T. Karring), p. 120. Quintessence Publishing, London.
13. AXELSSON, P. & LINDHE, J. (1981a) Effect of controlled oral hygiene procedures on caries and periodontal disease in adults. Results after 6yrs. Journal of Clinical Periodontology, 8, 239.
14. AXELSSON, P. & LINDHE, J. (1981b) The significance of maintenance care in the treatment of periodontal disease. Journal of Clinical Periodontology, 8, 281.
15. BAELUM, V., FEJERSKOV, O. & KARRING, T. (1986) Oral Hygiene, gingivitis and periodontal breakdown in adult Tanzanians. Journal of Periodontal Research, 21, 221.
16. BARKVOLI, P. & ROLLA, G. (1994) Triclosan protects the skin against dermatitis caused by sodium lauryl sulphate exposure. Journal of Clinical Periodontology, 21, 717.
17. CHRISTERSSON, L.A., WIKESJO, U.M.E., ALBINI, B., JAMBON, J.J. & GENCO, R.J. (1987) Tissue localisation of Actinobacillus actinomycetemcomitans in human periodontitis. Journal of Periodontology, 58, 540.
18. EL ATTAR, T.M.A. (1986) Prostaglandin E2 in human gingiva in health and disease and stimulation by female sex steroids. Proslaglandins, 11, 331.
19. FLOTRA, L., GJERMO, P., ROLLA, G. & WAERHAUG, J. (1971) Side effects of chlorhexidine mouthwashes. Scandinavian Journal of Dental Research, 79, 119.
20. FRANDSEN, A. (1986) Mechanical oral hygiene practices. In: Dental Plaque Control Measures and Oral Hygiene Practices (eds H. Loe & D.V. Kleinman), p. 93. IRL Press, Oxford.
21. GENCO, R.J. (1981) Antibiotics in the treatment of human periodontal diseases. Journal of Periodontology, 52, 545.
22. GJERMO, P. (1974) Chlorhexidine in dental practice. Journal of Clinical Periodontology, 1, 143.
23. GOLDHABER, P., RABADJIJA, L., BEYER, W.R. & KORNHAUSER, B. (1973) Bone resorption in tissue culture and its relevance to periodontal disease. Journal of the American Dental Association, 87, 1027.
24. GOODSON, J.M. (1994) Antimicrobial strategies for treatment of periodontal diseases. Periodontology 2000, 5, 142.
25. GOODSON, J.M., HAFFAJEE, A. & SOCRANSKY, S.S. (1979) Periodontal therapy by local delivery of tetracycline. Journal of Clinical Periodontology, 6, 83.
26. GOODSON, J.M., HOLBOROW, D., DUNN, R.L., HOGAN, P. & DUNHAM, S. (1983) Monolithic tetracycline-containing fibres for controlled delivery to periodorital pockets. Journal of Periodontology, 54, 575.
27. GOODSON, J.M., CUGINI, M.A., KENT, R.L. et al. (1991) Multicentre evaluation of tetracycline fibre therapy: clinical response. Journal of Periodontal Research, 26, 371.
28. GOODSON, J.M., DEWHIRST, F.E. & BRUNETTI, A. (1974) Prostaglandin E2 levels and human periodontal disease. Prostaglandins, 6, 81.
29. GOODSON, J.M., MCCLATCHY, K. & REVELL, C. (1974) Prostaglandin induced resorption of the adult rat calvarium. Journal of Dental Research, 53, 670.
30. GORDON, J.M., WALKER, C.B., MURPHY, J.C., GOODSON, J.M. & SOCRANSKY, S.S. (1981) Tetracycline: levels achievable in gingival crevicular fluid and in vitro effect on subgingival organisms. Part 1. Concentrations in crevicular fluid after repeated doses. Journal of Periodontology, 52, 609.
31. GRAHAME-SMITH, D.G. & ARONSON, J.K. (1984) Oxford Textbook of Clinical Pharmacology and Drug Therapy, p. 478. Oxford University Press, Oxford.
32. GROSSI, S.G., ZAMBON, J.J., HO, A.W. et al. (1994) Assessment of risk for periodontal disease. 1. Risk indicators for attachment loss. Journal of Periodontology, 65, 260.
33. HAFFAJEE, A.D. & SOCRANSKY, S.S. (1994) Microbial etiological agents of destructive periodontal diseases. Periodontology 2000, 5, 78.
34. HARDY, J.H., NEWMAN, H.N. & STRAHAN, J.D. (1982) Direct irrigation and subgingival plaque. Journal of Clinical Periodontology, 9, 57.
35. HEASMAN, P.A. & SEYMOUR, R.A. (1990) An association between long-term nonsteroidal antiinflammatory drug therapy and the severity of periodontal disease. Journal of Clinical Periodontology, 17, 654.
36. HEIJL, L., DAHLEN, G., SUNDIN, Y., WENANDER, A. & GOODSON, J.M. (1991) A 4-quadrant comparative study of periodontal treatment using tetracycline-containing drug delivery fibres and scaling. Journal of Clinical Periodontology, 18, 11.
37. HOWELL, T.H., JEFFCOAT, M.K., GOLDHABER, P., HALL, C., JOHNSON, H. & WILLIAMS, R.C. (1991) Inhibition of Alveolar Bone Loss in Beagles with the NSAID Naproxen. Journal of Periodontal Research, 26, 498.
38. HUGOSON, A. & JORDAN, T. (1982) Frequency distribution of individuals aged 20-70 years according to severity of periodontal disease. Community Dentistry and Oral Epidemiology, 10, 187.
39. JEFFCOAT, M.K., PAGE, R., REDDY, M. et al. (1991) Use of digital radiography to demonstrate the potential of naproxen as an adjunct in the treatment of rapidly progressive periodontal disease. Journal of Periodontal Research, 26, 415.
40. JOHNSON, N.W. (1994) Risk factors and diagnostic tests for destructive periodontitis. In: Proceedings of the 1st European Workshop on Periodontology (eds N.P. Lang & T. Karring), p. 90. Quintessence Publishing, London.
41. KALAGA, A., ADDY, M. & HUNTER, B. (1989a) Comparison of chlorhexidine delivery by mouthwash and spray on plaque accumulation. Journal of Periodontology, 60, 127.
42. KALAGA, A., ADDY, M. & HUNTER, B. (1989b) The use of 0.2% chlorhexidine as an adjunct to oral health in physically and mentally handicapped adults. Journal of Periodontology, 60, 381.
43. KELLY, A., RESTEGHINI, R., WILLIAMS, B. & DOLBY, A.E. (1985) Pressures recorded during periodontal pocket irrigation. Journal of Periodontology, 56, 297.
44. KIESER, J.B. (1994) Non-surgical periodontal therapy. In: Proceedings of the 1st European Workshop on Periodontology (eds N.P. Lang & T. Karring), p. 131. Quintessence Publishing, London.
45. KLEIN, D.C. & RAISZ, L.G. (1970) Prostaglandins: Stimulation of bone resorption in tissue culture. Endocrinology, 86, 1436.
46. KLINGE, B., ATTSTROM, R., KARRING, T., KISCH, J., LEWIN, B. & STOLTZE, K. (1992) 3 regimens of topical metronidazole compared to subgingival scling on periodontal pathology in adults. Journal of Clinical Periodontology, 19, 708.
47. KORNMAN, K., BLODGETT, S.R.F., BRUNSVOLD, M. & HOLT, S.C. (1990) Effects of topical application of meclofenamic acid and ibuprofen on bone loss, subgingival microb. Journal of Periodontal Research, 25, 300.
48. KORNMAN, K.S. (1986) Antimicrobial agents. In: Dental Plaque Control Measures and Oral Hygiene Practices (eds H. Loe & D.V. Kleinman), p. 121. IRL Press, Oxford.
49. LANG, N.P., ADLER, R., JOSS, A. & NYMAN, S. (1990) Absence of bleeding on probing. Journal of Clinical Periodontology, 17, 714.
50. LANG, N.P., JOSS, A., ORSANIC, T., GUSBERTI, F.A. & SIEGRIST, B.E. (1986) Bleeding on probing; a predictor for the progression of periodontal disease. Journal of Clinical Periodontology, 13, 590.
51. LAVSTEDT, S., MODEER, T. & WELANDER, E. (1982) Plaque and gingivitis in a group of Swedish School children with particular reference to tooth brushing habits. Acta Odontologica Scandinavica, 40, 307.
52. LINDHE, J. (1986) Gingivitis, general discussion. Journal of Clinical Periodontology, 13, 395.
53. LISTGARTEN, M.A., SCHIFTER, C.C. & LASTER, L. (1985) 3-year longitudinal study of the periodontal status of an adult population with gingivitis. Journal of Clinical Periodontology, 12, 225.
54. LOE, H. (1986) Progression of natural untreated periodontal disease in man. In: Borderland Between Caries and Periodontal Disease (ed T. Lehner), p. 35. 3rd edition. Medicine et Hyygiene, Geneve.
55. LOE, H. & SCHIOTT, C.R. ( 1970) The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. Journal of Periodontal Research, 5, 79.
56. LOE, H., THEILADE, E. & JENSEN, S.B. (1965) Experimental gingivitis in man. Journal of Periodonlology, 36, 177.
57. MANDEL, I.D. (1988) Chemotherapeutic agents for controlling plaque and gingivitis. Journal of Clinical Periodontology, 15, 488.
58. MOORE, W.E.C. & MOORE, L.V.H. (1994) The bacteria of periodontal diseases. Periodontology 2000, 5, 66.
59. MOORE, W.E.C. (1987) Microbiology of periodontal disease. Journal of Periodontal Research, 22, 335.
60. MORAN, J., ADDY., M., WADE, W. & NEWCOMBE, R. (1990) The use of antimicrobial acrylic strips in the non-surgical management of chronic periodontitis. Clinical Materials, 6, 123.
61. NEWMAN, P.S. & ADDY, M. (1978) A comparison of a periodontal dressing and chlorhexidine gluconate mouthwash after the internal bevel flap procedure. Journal of Periodontology, 49, 576.
62. NEWMAN, P.S. & ADDY, M. (1982) Comparison of Hypertonic saline and chlorhexidine mouthrinses after inverse bevel flap procedure. Journal of Periodontology, 53, 315.
63. NEWMAN, M.G., KORNMAN, K.S. & DOHERTY, F.M. (1994) A 6-month multicenter evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling and root planing in maintainance patients: clinical results. Journal of Periodontology, 65, 685.
64. NOVAK, M.J., POLSON, A.M. & ADAIR, S.M. (1988) Tetracycline therapy in patients with early juvenile periodontitis. Journal of Periodontology, 59, 366.
65. NOVAK, M.J., STAMATELAKYS, C. & ADAIR, S.M. (1991) Resolution of early lesions of juvenile periodontitis with tetracycline therapy alone: long term observations. Journal of Periodontology, 62, 628.
66. OFFENBACHER, S., BRASWELL, L.D., LOOS, A.S. et al (1987) The effects of flurbiprofen on the progression of periodontitis in Macaca mulatta. Journal of Periodontal Research, 22, 473.
67. OFFENBACHER, S., FARR, S.D.H. & GOODSON, J.M. (1981) Measurement of prostaglandin E in crevicular fluid. Journal of Clinical Periodontology, 8, 359.
68. OFFENBACHER, S., ODLE, B.M., & VAN DYKE, T.E. (1986) The use of crevicular fluid prostaglandin E2 levels as a predictor of periodontal attachment loss. Journal of Periodontal Research, 21, 101.
69. OFFENBACHER, S., WILLIAMS, R.C., JEFFCOAT, M.K. et al. (1992) Effects of NSAIDs on beagles crevicular fluid cyclooxygenase metabolites and periodontal bone loss. Journal of Periodontal Research, 27, 207.
70. PAPAPANOU, P.N. (1994) Epidemiology and natural history of periodontal disease. In: Proceedings of the 1st European Workshop on Periodontology (eds N.P. Lang & T. Karring), p. 23. Quintessence Publishing, London.
71. PEDRAZZOLI, V., KILIAN, M. & KARRING, T. (1992) Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. Journal of Clinical Periodontology, 19, 715.
72. PIHLSTROM, B., MICHALOWICZ, C., COBB, C., CATON, J., GOODSON, J.M. & ENCARNACION, M. (1994) Maintenance response to tetracycline fiber periodontal therapy. Journal of Periodontal Research, 73, 306 (Abstract No. 1638).
73. PRAYITNO, S.W., ADDY, M. & WADE, W.G. (1993) Does gingivitis lead to periodontitis in young adults. Lancet, 342, 471.
74. RABADJIJA, L. & GOLDHABER, P. (1974) Stimulation of bone resorption in tissue culture by arachidonic acid. IADR Abstracts, No. 342.
75. ROBERTS, W.R. & ADDY, M. (1981) Comparison of in vitro and in vivo antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, CPC and hexetidine. Relevance to mode of action. Journal of Clinical Periodontology, 8, 295.
76. ROBINSON, D. (1983) Prostaglandins and the mechanism of action of anti-inflammatory drugs. American Journal of Medicine, 75, 26.
77. SAXEN, L. & ASIKAINEN, S. (1993) Metronidazole in the treatment of localised juvenile periodontitis. Journal of Clinical Periodontology, 20, 166.
78. SCHIOTT, R.C., LOE, H., JENSEN, S.B., KILIAN, M., DAVIES, K.M. & GLAVIND, K. (1970) The effect of chlorhexidine mouthrinses on the human oral flora. Journal of Periodontal Research, 5, 84.
79. SEYMOUR, R.A. & HEASMAN, P.A. (1995) Tetracyclines in the management of periodontal diseases. Journal of Clinical Periodontology, 22, 22.
80. SLOTS, J. & GENCO, R.J. (1984) Black pigmented Bacteroides species, Capnocytophaga species and Actinobacillus actinomycetemcomitans in human periodontal disease: virulence factors in colonization, survival and tissue destruction. Journal of Dental Research, 63, 412.
81. SLOTS, J. & RAMS, T.E. (1990) Antibiotics in periodontal therapy: advantages and disadvantages. Journal of Clinical Periodontology, 17, 479.
82. SOCRANSKY, S.S. (1977) Microbiology of periodontal disease; present status and future considerations. Journal of Periodontology. 48, 497.
83. SOSKOLNE, A., GOLOMB, G., FRIEDMAN, M. & SELA, M.N. (1983) New sustained release dosage form of chlorhexidine for dental use. II. Use in periodontal therapy. Journal of Periododontal Research, 18, 330.
84. STEPHEN, K.W., SAXTON, C.A., JONES, C.L., RITCHIE, J.A. & MORRISON, T. (1990) Control of gingivitis and calculus by a dentifrice containing a zinc salt and triclosan. Journal of Periodontology, 61, 674.
85. STOLTZE, K. (1992) Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel. Journal of Clinical Periodontology, 19, 698.
86. SVATUN, B., SAXTON, C.A., ROLLA, G. & VAN DER OOERAA, F. (1989) A one year study on the maintainance of gingival health by a dentifrice containing a zinc salt and a non-ionic antimicrobial agent. Journal of Clinical Periodontology, 16, 75.
87. TOPOLL, H.H., LANGE, D.E. & MULLER, R.F. (1990) Multiple periodontal abscesses after systemic antibiotic therapy. Journal of Clinical Periodontology, 17, 268.
88. VAN PALENSTEIN HELDERMAN, W.H. (1986) Is antibiotic therapy justified in the treatment of human chronic inflammatory periodontal disease? Journal of Clinical Periodontology, 13, 932.
89. VAN STEENBERGHE, D., BERCY, P., KOHL, J. et al. (1993) Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: a randomised, double blind, vehicle controlled, multicenter study. Journal of Periodontology, 64, 637.
90. VAN WINKELHOFF, A.J., VAN STEENBERGEN, T.J.M. & DE GRAAFE, J. (1988) The role of black pigmented Bacteroides in human oral infections. Journal of Clinical Periodonlology, 15, 145.
91. VAN WINKELHOFF, A.J., TIJHOF, C.J. & DE GRAAF, J. (1992) Microbiological and clinical results of metronidazole plus amoxycillin therapy in Actinobacillus actinomycetemcomitans associated periodontitis. Journal of Periodontology, 63, 52.
92. VAN WINKELHOFF, A.J., PAVICIC, M. & DE GRAAFF, J. (1994) Antibiotics in periodontal therapy. In: Proceedings of the 1st European Workshop on Periodontology (eds N.P. Lang & T. Karring), p. 258. Quintessence Publishing, London.
93. VANE, J.R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature, 231, 232.
94. WACHTEL, H. (1994) Surgical periodontal therapy. In: Proceedings of the 1st European Workshop on Periodontology (eds N.P. Lang & T. Karring) p. 159. Quintessence Publishing, London.
95. WADE, W.G. & ADDY, M. (1987) A comparison of the in vitro activity of niridazole and metronidazole against subgingival bacteria in chronic periodontitis. Journal of Applied Bacteriology, 63, 455.
96. WADE, W., MORAN, J., MORGAN, J.R., NEWCOMBE, R. & ADDY, M. (1992) The effects of antimicrobial acrylic strips on the subgingival microflora in chronic periodontitis. Journal of Clinical Periodontology, 19, 127.
97. WHITE, D.J. (1995) A return to stannous fluoride dentifrices. Journal of Clinical Dentistry, 6, 29.
98. WILLIAMS, R.C., JEFFCOAT, M.K., KAPLAN, M.L., GOLDHABER, P., JOHNSON, H.G. & WECHTER, W.J. (1985) Flurbiprofen: A potent inhibitor of alveolar bone resoption in beagles. Science, 227, 640.
99. WILLIAMS, R.C., JEFFCOAT, M.K., WECHTER, W.J., JOHNSON, H.G., KAPLAN, M.L. & GOLDHABER, P. (1984) Nonsteroidal antiinflammatory drug treatment of periodontitis in beagles. Journal of Periodontal Research, 19, 633.
100. WONG, P.Y.K., ROSS, J.R. & STICHT, F.D. (1980) Metabolism of arachidonic acid in inflamed human gingiva: Function of 6-keto-prostaglandin F1alpha. Journal of Dental Research, 59, 670.
101. YATES, R., JENKINS, S., NEWCOMBE, R.G., WADE, W.G., MORAN, J. & ADDY, M. (1993) A 6-month home usage trial of a 1% chlorhexidine toothpaste. 1. Effects on plaque, gingivitis, calculus and tooth staining. Journal of Clinical Periodontology, 20, 130.