Acute generalized exanthematous pustulosis induced by hydroxychloroquine: Three cases and a review of the literature

Clinical Therapeutics

Volumn 30, Issue 5, 2008, Pages 930-940

  Paradisi, Andrea ^a   Bugatti, Leonardo ^b   Sisto, Teresa ^a   Filosa, Giorgio ^b   Amerio, Pier Luigi ^a   Capizzi, Rodolfo ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b 'A Murri Hospital   (Italy)

Author keywords

acute generalized exanthematous pustulosis; adverse drug reactions; hydroxychloroquine

Indexed keywords

DEFLAZACORT; HYDROXYCHLOROQUINE; METHOTREXATE; METHYLPREDNISOLONE; PANTOPRAZOLE; PREDNISOLONE; PREDNISONE; TELMISARTAN;

ACANTHOLYTIC DYSKERATOSIS; ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS; ADULT; AGED; ARTICLE; CASE REPORT; CORTICOSTEROID THERAPY; DISEASE DURATION; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; FEMALE; HUMAN; MALE; MEDICAL LITERATURE; PARAKERATOSIS; PSORIASIS; PUSTULOSIS; RASH; RHEUMATIC POLYMYALGIA; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME; SKIN EDEMA; SKIN EXFOLIATION; SKIN PRURITUS; TREATMENT DURATION; TREATMENT OUTCOME;

ACUTE DISEASE; ADULT; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; EXANTHEMA; FEMALE; HUMANS; HYDROXYCHLOROQUINE; MALE; SKIN DISEASES, VESICULOBULLOUS;

EID: 44849106776     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2008.05.014     Document Type: Article

References (48)

1. Arroyo M., Heller P., and Pomeranz M. Generalized pustules in a healthy woman. J Drugs Dermatol 1 (2002) 63-65
2. Sidoroff A., Halevy S., Bavinck J., et al. Acute generalized exanthematous pustulosis (AGEP)- a clinical reaction pattern. J Cutan Pathol 28 (2001) 113-119
3. Gebhardt M., Lustig A., Bocker T., and Wollina U. Acute generalized exanthematous pustulosis (A Manifestation of drug allergy to propicillin. Contact Dermatitis 33 (1995) 204-205
4. Belgodère X., Olivier V., Basteri M., et al. Acute generalized exanthematic pustulosis following administration of ceftriaxone. Int J Dermatol 39 (2000) 558-559
5. Kapoor R., Flynn C., Heald P., and Kapoor J. Acute generalized exanthematous pustulosis induced by clindamycin. Arch Dermatol 142 (2006) 1080-1081
6. Corral de la Calle M., Martin Díaz M., Flores C., and Vidaurrazaga C. Acute localized exanthematous putulosis secondary to levofloxacin. Br J Dermatol 152 (2005) 1076-1077
7. Burrows N., and Russell Jones R. Pustular drug eruptions: A histopatho logical spectrum. Histopathology 22 (1993) 569-573
8. Mackenzie A. Pharmacologic actions of 4-am minoquin noline compounds. Am J Med 75 (1983) 5-10
9. Plaquenil (hydroxychloroquine sulfate) tablets [October 5,2000: Sanofi]. www.fda.gov/medwatch/safety/2000/oct00.htm
10. Baker H., and Ryan T. Generalized pustular psoriasis: A clinical and epidemiological study of 104 cases. Br J Dermatol 80 (1968) 771-793
11. Beylot C., Bioulac P., and Doutre M. Acute generalized exanthematic pustuloses: Four cases. Ann Dermatol Venereol 107 (1980) 37-48
12. Roujeau J., Bioulac-Sage P., Bourseau C., et al. Acute generalized exanthematous pustulosis: Analysis of 63 cases. Arch Dermatol 127 (1991) 1333-1338
13. Bernard P., Lizeaux-Parneix V., Miossec V., et al. HLA et prédisposition génétique dans les pustuloses exanthématiques (PPEAG) et les exanthémes maculo-papuleux (EMP). Ann Dermatol Venerol 122 (1995) S38-S39
14. Eeckhout I., Noens L., Ongenae K., et al. Acute generalized exanthematic pustulosis: A case with a lymphoma-like presentation. Dermatology 194 (1997) 408-410
15. Röckl H. Leukocytoclastic vasculitis due to drug allergy presenting as generalized pustular exanthema [in Germ man]. Hautarzt 32 (1981) 467-470
16. Strutton G., Weedon D., and Robertson I. Pustular vasculitis of the hands. J Am Acad Dermatol 32 (1995) 192-198
17. Girardi M., Duncan K., Tigelaar R., et al. Cross-comparison of patch test and lymphocyte proliferation responses in patients with a history of acute generalized exanth hemato ous pustulosis. Am J Dermatopathol 27 (2005) 343-346
18. Britschgi M., Steiner U., Schmid S., et al. T-ccell involvement in drug-induced acute generalized exanthematous pustulosis. J Clin Invest 1107 (2001) 1433-1441
19. Schmid S., Kuechler P., Britschgi M., et al. Acute generalized exanthematous pustulosis: Role of cytotoxic T cells in pustule formation. Am J Pathol 161 (2002) 2079-2086
20. Sidoroff A., Dunant A., Viboud C., et al. Risk factors for acute generalized exhanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR). Br J Dermatol 157 (2007) 989-996
21. Saissi E., Beau-Salinas F., Jonville-Béra A., et al., for the Centres Régionaux de Pharmacovigilance. Drugs associated with acute generalized exanthematic pustulosis [in French ]. Ann Dermatol Venereol 130 (2003) 612-618
22. Salmeron G., and Lipsky P. Immunosuppressive potential of antimalarials. Am J Med 75 (1983) 19-24
23. Ward P. The chemosuppression of chemotaxis. J Exp Med 124 (1966) 209-226
24. Hurst N., French J., Bell A., et al. Differential effects of mepacrine, chloroquine and hydroxychloroquine on superoxide anion generation, phospholipid methylation and arachidonic acid release by human blood monocytes. Biochem Pharmacol 35 (1986) 3083-3089
25. Gliman A., Beams F., Tefft M., and Mazumder A. The effect of hydroxychloroquine on alloreactivity and its potential use for graft-versus-host-disease. Bone Marrow Transp plant 17 (1996) 1069-1075
26. Sperber K., Quraishi H., Kalb T., et al. Selective regulation of cytokine secretion by hydroxychloroquine: Inhibition of interleukin-1-alpha (IIL-11- a) and IL-66 in human monocytes and T cells. J Rheumatol 20 (1993) 803-808
27. Goldman F., Gliman A., Hollenback C., et al. Hydroxychloroquine inhibits calcium signals in T cells: A new mechanism to explain its immunomodulatory properties. Blood 95 (2000) 3460-3466
28. Wallace D. The history of antimalarials. Lupus 55 Suppl 1 (1996) S2-S3
29. Fardet L., and Revuz J. Synthetic antimala aria als [in French]. Ann Dermatol Venereol 132 (2005) 665-674
30. Salido M., Joven B., D'Cruz D., et al. Increased cutaneous reactions to hydroxychloroquine (Plaquenil) possibly associated with formulation change: Comment on the letter by Alarcón. Arthritis Rheum 46 (2002) 3392-3396
31. Degos R., Touraine R., Civatte J., and Bela auic ch S. Erythroderma with appearance of pustular psoriasis during a case of Duhring's disease treated with hydroxychloroquine [in French ]. Bull Soc Fr Dermatol Syphiligr 70 (1963) 129-134
32. Friedman S. Pustular psoriasis associated with hydroxychloroquine. J Am Acad Dermatol 16 (1987) 1256-1257
33. Lotem M., Ingber A., Segal R., and Sandbank M. Generalized pustular drug rash in nduced by hydroxychloroquine. Acta Derm Venereol 70 (1990) 250-251
34. Assier H., Auffret N., Beltzer-Garelly E., et al. Acute generalized exanthematous pustulosis induced by hydroxychloroquine [in French]. Ann Dermatol Venereol 120 (1993) 848-850
35. Bonnetblanc J., Combeau A., and Dang P. Hydroxychloroquinepuvatherapy photoinduced acute generalized exanthematous pustulosis [in French ]. Ann Dermatol Venereol 122 (1995) 604-605
36. Assier-Bonnet H., Saada V., Bernier M., et al. Acute generalized exanthematous pustulosis induced by hydroxychloroquine. Dermatology 193 (1996) 70-71
37. Evans C., and Bergstresser P. Acute generalized exanthematous pustulosis precipitated by hydroxychloroquine. J Am Acad Dermatol 50 (2004) 650-651
38. Martins A., Lopes L., Paiva Lopes M., and Rodrigues J. Acute generalized exanthematous pustulosis induced by hydroxychloroquine. Eur J Dermatol 16 (2006) 317-318
39. Slagel G., and James W. Plaquenil-induced erythroderma. J Am Acad Dermatol 12 (1985) 857-862
40. Baker H. The influence of chloroquine and related drugs on psoriasis and keratoderma blenorrhagicum. Br J Dermatol 78 (1966) 161-166
41. Vine J., Hymes S., Warner N., and Cohen P. Pustular psoriasis induced by hydroxychloroquine: A case report and review of the literature. J Dermatol 23 (1996) 357-361
42. Wolf R., Lo Schiavo A., Lombardi M., et al. The in vitro effect of hydroxychloroquine on skin morphology and transglutaminase. Int J Dermatol 36 (1997) 704-707
43. Yamasaki R., Yamasaki M., Kawasaki Y., and Nagasako R. Generalized pustular dermatosis caused by isoniazid. Br J Dermatol 112 (1985) 504-506
44. Plantin P., Piette F., Le Roy J., et al. Toxidermies exanthématiques et pustuleuses: A propos de 6 cas, revue de la littérature. Rech Dermatol 1 (2004) 385-394
45. Lambert D., Dalac S., Beer F., et al. Acute generalized exanthematous pustular dermatitis induced by diltiazem. Br J Dermatol 118 (1988) 308-309
46. Sontheimer R. Desensitization to hydroxychloroquine: Alternative interpretations. J Rheumatol 34 (2007) 253-255
47. Clark P., Casas E., Tugwell P., et al. Hydroxychloroquine compared with placebo in rheumatoid arthritis. A randomized controlled trial. Ann Intern Med 119 (1993) 1067-1071
48. Furst D., Lindsley H., Baethge B., et al. Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: A randomized, double-blind, six-week trial with eighteen-week exten nsio on. Arth hrit tis Rheum 42 (1999) 357-365