How should we manage pain in ventilated neonates?

Neonatology

Volumn 93, Issue 4, 2008, Pages 316-323

  Menon, Gopi ^a   McIntosh, Neil ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Analgesia; Artificial respiration; Benzodiazepines; Muscle relaxant; Newborn infant; Opiate alkaloid; Pain; Stress

Indexed keywords

ANESTHETIC AGENT; BENZODIAZEPINE; FENTANYL; KETAMINE; LIDOCAINE; MIDAZOLAM; MORPHINE; MUSCLE RELAXANT AGENT; OPIATE; PANCURONIUM; PLACEBO; PRILOCAINE; SUCROSE; TETRACAINE;

ARTIFICIAL VENTILATION; CANNULATION; CLINICAL PRACTICE; CLINICAL TRIAL; CONFERENCE PAPER; DISEASE SEVERITY; DISTRESS SYNDROME; GENERAL ANESTHESIA; HUMAN; INTUBATION; LOCAL ANESTHESIA; MORBIDITY; NECROTIZING ENTEROCOLITIS; NEWBORN CARE; NURSING CARE; PAIN; PARALYSIS; PHLEBOTOMY; POSTOPERATIVE PAIN; PREMATURITY; PRIORITY JOURNAL; RETINOPATHY; SEDATION; UNSPECIFIED SIDE EFFECT;

ANALGESIA; ANALGESICS, OPIOID; BENZODIAZEPINES; CONSCIOUS SEDATION; HUMANS; HYPNOTICS AND SEDATIVES; INFANT, NEWBORN; INFANT, PREMATURE; INTENSIVE CARE, NEONATAL; PAIN; RESPIRATION, ARTIFICIAL; STRESS, PSYCHOLOGICAL;

EID: 44849085847     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000121458     Document Type: Conference Paper

References (63)

1. Forfar JO, Campbell A: Medicine and the media. BMJ 1987;295:659-660.
2. Anand KJ: Neonatal stress responses to anesthesia and surgery. Clin Perinatol 1990;17:207-214.
3. Grunau RV, Whitfield MF, Petrie JH: Pain sensitivity and temperament in extremely low-birth-weight premature toddlers and preterm and full-term controls. Pain 1994;58:341-346.
4. Grunau RV, Whitfield MF, Petrie JH, Fryer EL: Early pain experience, child and family factors, as precursors of somatization: a prospective study of extremely premature and fullterm children. Pain 1994;56:353-359.
5. Granja C, Lopes A, Moreira S, Dias C, Costa-Pereira A: Patients' recollections of experiences in the intensive care unit may affect their quality of life. Crit Care 2005;9:R96-R109.
6. Hughes D, Murphy JF, Dyas J, Robinson JA, Riad-Fahmy D, Hughes IA: Blood spot glucocorticoid concentrations in ill preterm infants. Arch Dis Child 1987;62:1014-1018.
7. Evans DJ, MacGregor RJ, Dean HG, Levene MI: Neonatal catecholamine levels and neurodevelopmental outcome: a cohort study. Arch Dis Child Fetal Neonatal Ed 2001;84:F49-F52.
8. Barker DP, Rutter N: Stress, severity of illness, and outcome in ventilated preterm infants. Arch Dis Child 1996;75:187-190.
9. Aretz S, Licht C, Roth B: Endogenous distress in ventilated full-term newborns with acute respiratory failure. Biol Neonate 2004;85:243-248.
10. Quinn MW, de Boer RC, Ansari N, Baumer JH: Stress response and mode of ventilation in preterm infants. Arch Dis Child Fetal Neonatal Ed 1998;78:F195-F198.
11. Johnston CC, Collinge JM, Henderson SJ, Anand KJ: A cross-sectional survey of pain and pharmacological analgesia in Canadian neonatal intensive care units. Clin J Pain 1997;13:308-312.
12. Wilson A, Gardner MN, Armstrong MA, Folck BF, Escobar GJ: Neonatal assisted ventilation: predictors, frequency, and duration in a mature managed care organization. Pediatrics 2000;105:822-830.
13. St John EB, Carlo WA: Respiratory distress syndrome in VLBW infants: changes in management and outcomes observed by the NICHD Neonatal Research Network. Semin Perinatol 2003;27:288-292.
14. Simons SH, van Dijk M, Anand KS, Roofthooft D, van Lingen RA, Tibboel D: Do we still hurt newborn babies? A prospective study of procedural pain and analgesia in neonates. Arch Pediatr Adolesc Med 2003;157:1058-1064.
15. Anand KJ, Hickey PR: Halothane-morphine compared with high-dose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery. N Engl J Med 1992;326:1-9.
16. Pokela ML: Pain relief can reduce hypoxaemia in distressed neonates during routine treatment procedures. Pediatrics 1994;93:379-383.
17. Goldstein RF, Brazy JE: Narcotic sedation stabilizes arterial blood pressure fluctuations in sick premature infants. J Perinatol 1991;11:365-371.
18. Orsini AJ, Leef KH, Costarino A, Dettore MD, Stefano JL: Routine use of fentanyl infusions for pain and stress reduction in infants with respiratory distress syndrome. J Pediatr 1996;129:140-145.
19. Dyke MP, Kohan R, Evans S: Morphine increases synchronous ventilation in preterm infants. J Paediatr Child Health 1995;31:176-179.
20. Quinn MW, Wild J, Dean HG, Hartley R, Puntis JW, Levene MI: Randomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated pre-term babies. Lancet 1993;342:324-327.
21. Saarenmaa E, Huttunen P, Leppaluoto J, Meretoja O, Fellman V: Advantages of fentanyl over morphine in analgesia for ventilated newborn infants after birth: a randomized trial. J Pediatr 1999;134:144-150.
22. Lago P, Benini F, Agosto C, Zacchello F: Randomised controlled trial of low dose fentanyl infusion in preterm infants with hyaline membrane disease. Arch Dis Child Fetal Neonatal Ed 1998;79:F194-F197.
23. Anand KJS, McIntosh N, Lagerkrantz H: Analgesia and sedation in ventilated preterm neonates: results from the pilot N.O.P.A.I.N. trial. Arch Pediatr Adolesc Med 1999;153:331-338.
24. Anand KJ, Hall RW, Desai N, Shephard B, Bergqvist LL, Young TE, Boyle EM, Carbajal R, Bhutani VK, Moore MB, Kronsberg SS, Barton BA: Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. Lancet 2004;363:1673-1682.
25. Simons SH, van Dijk M, Van Lingen RA, Roofthooft D, Duivenvoorden HJ, Jongeneel N, Bunkers C, Smink E, Anand KJ, van den Anker JN, Tibboel D: Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. JAMA 2003;290:2419-2427.
26. MacGregor R, Evans D, Sugden D, Gaussen T, Levene M: Outcome at 5-6 years of prematurely born children who received morphine as neonates. Arch Dis Child Fetal Neonatal Ed 1998;79:F40-F43.
27. Bolivar JM, Gerhardt T, Gonzalez A, Hummler H, Claure N, Everett R, Bancalari E: Mechanisms for episodes of hypoxemia in preterm infants undergoing mechanical ventilation. J Pediatr 1995;127:767-773.
28. Cools F, Offringa M: Neuromuscular paralysis for newborn infants receiving mechanical ventilation. Cochrane Database Syst Rev 2005:CD002773.
29. Jacqz-Aigrain E, Daoud P, Burtin P, Desplanqueles L, Beaufils F: Placebo-controlled trial of midazolam sedation in mechanically ventilated newborn babies. Lancet 1994;344:646-650.
30. Arya V, Ramji S: Midazolam sedation in mechanically ventilated newborns: a double blind randomized placebo controlled trial. Ind Pediatr 2001;38:967-972.
31. Quinn MW, Otoo F, Rushforth JA: Effect of morphine and pancuronium on the stress response in ventilated preterm infants. Early Hum Dev 1992;30:241-248.
32. Bellieni CV, Buonocore G, Nenci A, Franci N, Cordelli DM, Bagnoli F: Sensorial saturation: an effective analgesic tool for heel-prick in preterm infants. A prospective randomised trial. Biol Neonate 2001;80:15-18.
33. Als H, Gilkerson L, Duffy FH, McAnulty GB, Buehler DM, Vandenberg K, Sweet N, Sell E, Parad RB, Ringer SA, Butler SC, Blickman JG, Jones KJ: A three-center, randomized, controlled trial of individualized developmental care for very low birth weight preterm infants: medical, neurodevelopmental, parenting, and caregiving effects. J Dev Behav Pediatr 2003;24:399-408.
34. Anand KJS: Clinical importance of pain and stress in preterm neonates. Biol Neonate 1998;73:1-9.
35. Anand KJ, Johnston CC, Oberlander TF, Taddio A, Lehr VT, Walco GA: Analgesia and local anesthesia during invasive procedures in the neonate. Clin Ther 2005;27:844-876.
36. Carbajal R, Lenclen R, Jugie M, Paupe A, Barton BA, Anand KJ: Morphine does not provide adequate analgesia for acute procedural pain among preterm neonates. Pediatrics 2005;115:1494-1500.
37. Saarenmaa E, Huttunen P, Leppaluoto J, Fellman V: Alfentanil as procedural pain relief in newborn infants. Arch Dis Child Fetal Neonatal Ed 1996;75:F103-F107.
38. Carbajal R, Eble B, Anand KJ: Premedication for tracheal intubation in neonates: confusion or controversy? Semin Perinatol 2007;31:309-317.
39. Louon A, Lithander J, Reddy VG, Gupta A: Sedation with nasal ketamine and midazolam for cryotherapy in retinopathy of prematurity. Br J Ophthalmol 1993;77:529-530.
40. Kirwan C, O'Keefe M, Prendergast M, Twomey A, Murphy J: Morphine analgesia as an alternative to general anaesthesia during laser treatment of retinopathy of prematurity. Acta Ophthalmol Scand 2007;85:644-647.
41. Larsson BA, Tannfeldt G, Lagerkrantz H, Ohlsson GL: Alleviation of the pain of venepuncture in neonates. Acta Paediatr 1998;87:774-779.
42. Jain A, Rutter N: Does topical amethocaine gel reduce the pain of venepuncture in newborn infants? A randomised double blind controlled trial. Arch Dis Child Fetal Neonatal Ed 2000;83:F207-F210.
43. Long CP, McCafferty DF, Sittlington NM, Halliday HL, Woolfson AD, Jones DS: Randomized trial of novel tetracaine patch to provide local anaesthesia in neonates undergoing venepuncture. Br J Anaesth 2003;91:514-518.
44. Larsson BA, Norman M, Bjerring P, Egekvist H, Lagerkrantz H, Ohlsson GL: Regional variations in skin perfusion and skin thickness may contribute to varying efficacy of topical, local anaesthetics in neonates. Paediatr Anaesth 1996;6:107-110.
45. Ballantyne M, McNair C, Ung E, Gibbons S, Stevens B: A randomized controlled trial evaluating the efficacy of tetracaine gel for pain relief from peripherally inserted central catheters in infants. Adv Neonatal Care 2003;3:297-307.
46. McIntosh N, van Veen L, Bramayer H: Alleviation of the pain of heel prick in preterm infant s. Arch Dis Child Fetal Neonatal Ed 1994;70:F177-F181.
47. Stevens B, Yamada J, Ohlsson A: Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev 2004;3:CD001069.
48. Yaster M, Nichols DG, Deshpande JK, Wetzel RC: Midazolam-fentanyl intravenous sedation in children: case report of respiratory arrest. Pediatrics 1990;86:463-467.
49. Hall RW, Kronsberg SS, Barton BA, Kaiser JR, Anand KJ: Morphine, hypotension, and adverse outcomes among preterm neonates: who's to blame? Secondary results from the NEOPAIN trial. Pediatrics 2005;115:1351-1359.
50. Menon G, Boyle EM, McIntosh N, Barton BA, Anand KJ: Morphine analgesia and gastrointestinal morbidity in preterm infants: secondary results from the NEOPAIN Trial. Arch Dis Child Fetal Neonatal Ed 2007;Epub ahead of print.
51. Fahnenstich H, Steffan J, Kau N, Bartmann P: Fentanyl-induced chest wall rigidity and laryngospasm in preterm and term infants. Crit Care Med 2000;28:836-839.
52. Suresh S, Anand KJ: Opioid tolerance in neonates: a state-of-the-art review. Paediatr Anaesth 2001;11:511-521.
53. Chang AP, Dixon WR: Role of plasma catecholamines in eliciting cardiovascular changes seen during naloxone-precipitated withdrawal in conscious, unrestrained morphine-dependent rats. J Pharmacol Exp Ther 1990;254:857-863.
54. Johnson C, Mayer P, Grosz D: Pulmonary edema following naloxone administration in a healthy orthopedic patient. J Clin Anesth 1995;7:356-357.
55. Moe V: Foster-placed and adopted children exposed in utero to opiates and other substances: prediction and outcome at four and a half years. J Dev Behav Pediatr 2002;23:330-339.
56. Lesage J, Bernet F, Montel V, Dupouy JP: Effects of prenatal morphine on hypothalamic metabolism of neurotransmitters and gonadal and adrenal activities, during the early postnatal period in the rat. Neurochem Res 1996;21:723-732.
57. Johnston CC, Filion F, Snider L, Majnemer A, Limperopoulos C, Walker CD, Veilleux A, Pelausa E, Cake H, Stone S, Sherrard A, Boyer K: Routine sucrose analgesia during the first week of life in neonates younger than 31 weeks' postconceptional age. Pediatrics 2002;110:523-528.
58. Symington A, Pinelli J: Developmental care for promoting development and preventing morbidity in preterm infants. Cochrane Database Syst Rev 2006;2:CD001814.
59. Kennedy KA, Tyson JE: Narcotic analgesia for ventilated newborns: are placebo-controlled trials ethical and necessary? J Pediatr 1999;134:127-129.
60. Orzalesi M, Cuttini M: Ethical considerations in neonatal respiratory care. Neonatology 2005;87:345-353.
61. Hickey PR, Hansen DD, Wessel DL, Lang P, Jonas RA, Elixson EM: Blunting of stress responses in the pulmonary circulation of infants by fentanyl. Anesth Analg 1985;64:1137-1142.
62. Abad F, Diaz NM, Domenech E, Robayna M, Rico J: Oral sweet solution reduces pain-related behaviour in preterm infants. Acta Paediatr 1996;85:854-858.
63. Boyle EM, Freer Y, Khan-Orakzai Z, Watkinson M, Wright E, Ainsworth JR, McIntosh N: Sucrose and non-nutritive sucking for the relief of pain in screening for retinopathy of prematurity: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 2006;91:F166-F168.