Identification of Naturally Processed Helper T-Cell Epitopes from Prostate-Specific Membrane Antigen Using Peptide-Based in Vitro Stimulation

Clinical Cancer Research

Volumn 9, Issue 14, 2003, Pages 5386-5393

  Kobayashi, Hiroya ^a,b   Omiya, Ryusuke ^a   Sodey, Benjamin ^a   Yanai, Mitsuru ^b   Oikawa, Kensuke ^b   Sato, Keisuke ^b   Kimura, Shoji ^b   Senju, Satoru ^b,c   Nishimura, Yasuharu ^c   Tateno, Masatoshi ^b   Celis, Esteban ^a,d  

^a MAYO GRADUATE SCHOOL   (United States)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; PROSTATE SPECIFIC MEMBRANE ANTIGEN; TUMOR ANTIGEN; VACCINE;

ALGORITHM; ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL LYSATE; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOTHERAPY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROSTATE CANCER; VACCINATION;

ANIMALS; ANTIGENS, SURFACE; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; GLUTAMATE CARBOXYPEPTIDASE II; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; MALE; MICE; PEPTIDE FRAGMENTS; PROSTATIC NEOPLASMS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 10744224291     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. American Cancer Society, Inc. Cancer Facts & Figures 2002. Atlanta, GA: American Cancer Society, Inc., 2002.
2. Edwards, B. K., Howe, H. L., Ries, L. A. G., Thun, M. J., Rosenberg, H. M., Yancik, R., Wingo, P. A., Jemal, A., and Feigal, E. G. Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U. S. cancer burden. Cancer (Phila.), 94: 2766-2792, 2002.
3. Israeli, R. S., Powell, C. T., Corr, J. G., Fair, W. R., and Heston, W. D. W. Expression of the prostate-specific membrane antigen. Cancer Res., 54: 1807-1811, 1994.
4. Israeli, R. S., Powell, C. T., Fair, W. R., and Heston, W. D. W. Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res., 53: 227-230, 1993.
5. Lu, J., and Celis, E. Recognition of prostate tumor cells by cytotoxic T lymphocytes specific for prostate-specific membrane antigen. Cancer Res., 62: 5807-5812, 2002.
6. Horiguchi, Y., Nukaya, I., Okazawa, K., Kawashima, I., Fikes, J., Sette, A., Tachibana, M., Takesako, K., and Murai, M. Screening of HLA-A24-restricted epitope peptides from prostate-specific membrane antigen that induce specific antitumor cytotoxic T lymphocytes. Clin. Cancer Res., 8: 3885-3892, 2002.
7. Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., and Schoenberger, S. P. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature (Lond.), 421: 852-856, 2003.
8. Bourgeois, C., Rocha, B., and Tanchot, C. A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science (Wash. DC), 297: 2060-2063, 2002.
9. Sun, J. C., and Bevan, M. J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science (Wash. DC), 300: 339-342, 2003.
10. Shedlock, D. J., and Shen, H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science (Wash. DC), 300: 337-339, 2003.
11. Buteau, C., Markovic, S. N., and Celis, E. Challenges in the development of effective peptide vaccines for cancer. Mayo Clin. Proc., 77: 339-349, 2002.
12. Pardoll, D. M., and Topalian, S. L. The role of CD4+ T cell responses in antitumor immunity. Curr. Opin. Immunol., 10: 588-594, 1998.
13. Giuntoli, R. L. 2nd, Lu, J., Kobayashi, H., Kennedy, R., and Celis, E. Direct costimulation of tumor-reactive CTL by helper T cells potentiate their proliferation, survival, and effector function. Clin. Cancer Res., 8: 922-931, 2002.
14. Southwood, S., Sidney, J., Kondo, A., del Guercio, M. F., Appella, E., Hoffman, S., Kubo, R. T., Chesnut, R. W., Grey, H. M., and Sette, A. Several common HLA-DR types share largely overlapping peptide binding repertoires. J. Immunol., 160: 3363-3373, 1998.
15. Kobayashi, H., Omiya, R., Ruiz, M., Huarte, E., Sarobe, P., Lasarte, J. J., Herraiz, M., Sangro, B., Prieto, J., Borras-Cuesta, F., and Celis, E. Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen. Clin. Cancer Res., 8: 3219-3225, 2002.
16. Kobayashi, H., Lu, J., and Celis, E. Identification of helper T-cell epitopes that encompass or lie proximal to cytotoxic T-cell epitopes in the gp100 melanoma tumor antigen. Cancer Res., 61: 7577-7584, 2001.
17. Kobayashi, H., Song, Y., Hoon, D. S., Appella, E., and Celis, E. Tumor-reactive T helper lymphocytes recognize a promiscuous MAGE-A3 epitope presented by various major histocompatibility complex class II alleles. Cancer Res., 61: 4773-4778, 2001.
18. Lampson, L. A., and Levy, R. Two populations of Ia-like molecules on a human B cell line. J. Immunol., 125: 293-299, 1980.
19. Omiya, R., Buteau, C., Kobayashi, H., Paya, C. V., and Celis, E. Inhibition of EBV-induced lymphoproliferation by CD4(+) T cells specific for an MHC class II promiscuous epitope. J. Immunol., 169: 2172-2179, 2002.
20. Kobayashi, H., Wood, M., Song, Y., Appella, E., and Celis, E. Defining promiscuous MHC class II helper T-cell epitopes for the HER2/neu tumor antigen. Cancer Res., 60: 5228-5236, 2000.
21. Hural, J. A., Friedman, R. S., McNabb, A., Steen, S. S., Henderson, R. A., and Kalos, M. Identification of naturally processed CD4 T cell epitopes from the prostate-specific antigen kallikrein 4 using peptide-based in vitro stimulation. J. Immunol., 169: 557-565, 2002.
22. Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R., and Melief, C. J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions Nature (Lond.), 393: 480-483, 1998.
23. Bennett, S. R., Carbone, F. R., Karamalis, F., Flavell, R. A., Miller, J. F., and Heath, W. R. Help for cytotoxic-T-cell responses is mediated by CD40 signalling Nature (Lond.), 393: 478-480, 1998.
24. Ridge, J. P., Di Rosa, F., and Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell Nature (Lond.), 393: 474-478, 1998.