C3435T polymorphism of the MDR1 gene is not associated with P-glycoprotein function of leukemic blasts and clinical outcome in patients with acute myeloid leukemia

Leukemia Research

Volumn 32, Issue 10, 2008, Pages 1601-1604

  Hur, Eun Hye ^a   Lee, Je Hwan ^a   Lee, Michael Jinpyo ^a   Choi, Seong Jun ^a   Lee, Jung Hee ^a   Kang, Mun Jung ^a   Seol, Miee ^a   Jang, Yae Eun ^a   Lee, Hee Jung ^a   Kang, Ip Sol ^a   Shim, Soo Kyung ^a   Ryu, Seong Gil ^a   Kang, Young Ah ^a   Lee, Young Shin ^a   Park, Chan Jeoung ^a   Chi, Hyun Sook ^a   Lee, Kyoo Hyung ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

AML; MDR1; P glycoprotein; Polymorphism

Indexed keywords

GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; BLAST CELL; CANCER SURVIVAL; DISEASE FREE SURVIVAL; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; SURVIVAL RATE;

ADULT; FEMALE; GENES, MDR; GENOTYPE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; P-GLYCOPROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 44749085788     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2007.12.013     Document Type: Article

References (6)

1. Ambudkar S.V., Dey S., Hrycyna C.A., Ramachandra M., Pastan I., and Gottesman M.M. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39 (1999) 361-398
2. Hoffmeyer S., Burk O., von Richter O., Arnold H.P., Brockmoller J., Johne A., et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 97 (2000) 3473-3478
3. Kim D.H., Park J.Y., Sohn S.K., Lee N.Y., Baek J.H., Jeon S.B., et al. Multidrug resistance-1 gene polymorphisms associated with treatment outcomes in de novo acute myeloid leukemia. Int J Cancer 118 (2006) 2195-2201
4. Illmer T., Schuler U.S., Thiede C., Schwarz U.I., Kim R.B., Gotthard S., et al. MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients. Cancer Res 62 (2002) 4955-4962
5. Jamroziak K., Balcerczak E., Cebula B., Janus A., Mirowski M., and Robak T. No influence of 3435C > T ABCB1 (MDR1) gene polymorphism on risk of adult acute myeloid leukemia and P-glycoprotein expression in blast cells. Ther Drug Monit 28 (2006) 707-711
6. van der Holt B., Van den Heuvel-Eibrink M.M., Van Schaik R.H., van der Heiden I.P., Wiemer E.A., Vossebeld P.J., et al. ABCB1 gene polymorphisms are not associated with treatment outcome in elderly acute myeloid leukemia patients. Clin Pharmacol Ther 80 (2006) 427-439