Air-coupled non-contact mechanical property determination of drug tablets

International Journal of Pharmaceutics

Volumn 359, Issue 1-2, 2008, Pages 25-34

  Akseli, Ilgaz ^a   Cetinkaya, Cetin ^a  

^a Clarkson University   (United States)

Author keywords

Acoustic process monitoring; Drug tablet characterization; Drug tablet mechanical properties; Non contact process pharmaceutical monitoring; Process Analytical Technology

Indexed keywords

DRUG;

ACOUSTIC IMPEDANCE; ARTICLE; LASER; METHODOLOGY; PHYSICAL CHEMISTRY; PHYSICAL PARAMETERS; PRIORITY JOURNAL; ULTRASOUND; VIBRATION;

ACOUSTICS; CHEMISTRY, PHARMACEUTICAL; FINITE ELEMENT ANALYSIS; INTERFEROMETRY; LASERS; PHARMACEUTICAL PREPARATIONS; TABLETS; TECHNOLOGY, PHARMACEUTICAL; ULTRASONICS; VIBRATION;

EID: 44749085534     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.03.020     Document Type: Article

References (31)

1. ABAQUS Theory Manual, 2007. Version 6.7, Dassault Systèmes SIMULIA Corporation, pp. 2.4.1-1-2.4.1-7.
2. Akseli I., and Cetinkaya C. Drug tablet thickness estimations using air-coupled acoustics. Int. J. Pharm. 351 (2008) 165-173
3. Bassam F., York P., Rowe R.C., and Roberts R.J. Young's modulus of powders used as pharmaceutical excipients. Int. J. Pharm. 64 (1990) 55-60
4. Berkovich E.S. Three-faceted diamond pyramid for micro-hardness testing. Ind. Diamond Rev. 11 (1951) 129-132
5. Blanco M., and Alcala M. Content uniformity and tablet hardness testing of intact pharmaceutical tablets by near infrared spectroscopy - a contribution to process analytical technologies. Anal. Chim. Acta 557 (2006) 353-359
6. Cetinkaya C., Akseli I., Mani G.N., Libordi C.F., and Varghese I. Non-contact mechanical characterization and testing of drug tablets. In: Kundu T. (Ed). Advanced Ultrasonic Methods for Material and Structure Inspection (2006), ISTE Science and Technical Publishing, UK pp. 319-369
7. Chen Y.X., Thosar S.S., Forbess R.A., Kemper M.S., Rubinovitz R.L., and Shukla A.J. Prediction of drug content and hardness of intact tablets using artificial neural network and near-infrared spectroscopy. Drug Dev. Ind. Pharm. 27 (2001) 623-631
8. Donoso M., Kildsig D.O., and Ghaly E.S. Prediction of tablet hardness and porosity using near-infrared diffuse reflectance spectroscopy as a nondestructive method. Pharm. Dev. Technol. 8 (2003) 357-366
9. Fell J.T., and Newton J.M. Tensile strength of lactose tablets. J. Pharm. Pharmacol. 20 (1968) 657-659
10. Felton L.A., Shah N.H., Zhang G., Infeld M.H., Malick A.W., and McGinity J.W. Physical-mechanical properties of film-coated soft gelatin capsules. Int. J. Pharm. 127 (1996) 203-211
11. Hakanen A., and Laine E. Acoustic emission during powder compaction and its frequency spectral analysis. Drug Dev. Ind. Pharm. 19 (1993) 2539-2560
12. Hakanen A., and Laine E. Acoustic characterization of a micro-crystalline cellulose powder during and after its compression. Drug Dev. Ind. Pharm. 21 (1995) 1573-1582
13. Hancock B.C., Colvin J.T., Mullarney M.P., and Zinchuk A.V. The relative densities of pharmaceutical powders, blends, dry granulations, and immediate-release tablets. Pharm. Technol. 27 (2003) 64-80
14. Hardy I.J., and Cook W.G. Predictive and correlative techniques for the design, optimization and manufacture of solid dosage forms. J. Pharm. Pharmacol. 55 (2003) 3-18
15. Hussain A.S., Watts C., Afnan A.M., and Wu H. Foreword. J. Process Anal. Technol. 1 (2004) 3-4
16. Inman S.J., Briscoe B.J., and Pitt K.G. Topographic characterization of cellulose bilayered tablets interfaces. Chem. Eng. Res. Des. 85 (2007) 1005-1012
17. Jetzer W., Leuenberger H., and Sucker H. The compressibility and compatibility of pharmaceutical powders. Pharm. Technol. 7 (1983) 33-39
18. Kirsch J.D., and Drennen J.K. Nondestructive tablet hardness testing by near-infrared spectroscopy: a new and robust spectral best-fit algorithm. J. Pharm. Biomed. Anal. 19 (1999) 351-362
19. Morisseau K.M., and Rhodes C.T. Near-infrared spectroscopy as a nondestructive alternative to conventional tablet hardness testing. Pharm. Res. 14 (1997) 108-111
20. Otsuka M., and Yamane I. Prediction of tablet hardness based on near infrared spectra of raw mixed powders by chemometrics. J. Pharm. Sci. 95 (2006) 1425-1433
21. Payne R.S., Roberts R.J., Rowe R.C., McPartlin M., and Bashall A. The mechanical properties of two forms of primidone predicted from their crystal structures. Int. J. Pharm. 145 (1996) 165-173
22. Podczeck F., Drake K.R., Newton J.M., and Haririan I. The strength of bilayered tablet. Eur. J. Pharm. Sci. 29 (2006) 361-366
23. Rigdway K., and Aulton M.E. The surface hardness of tablets. J. Pharm. Pharmacol. 22 (1970) 70-78
24. Roberts R.J., and Rowe R.C. The Young's modulus of pharmaceutical materials. Int. J. Pharm. 37 (1987) 15-18
25. Roberts R.J., and Rowe R.C. Relationships between the modulus of elasticity and tensile strength for pharmaceutical drugs and excipients. J. Pharm. Pharmacol. 51 (1999) 975-977
26. Roberts R.J., Payne R.S., and Rowe R.C. Mechanical property predictions for polymorphs of sulphathiazole and carbamazepine. Eur. J. Pharm. Sci. 9 (2000) 277-283
27. Serris E., Camby-Perier L., Thomas G., Desfontaines M., and Fantozzi G. Acoustic emission of pharmaceutical powders during compaction. Powder Technol. 128 (2002) 296-299
28. Stanley P., Rowe R.C., and Newton J.M. Theoretical considerations of the influence of polymer film coatings on the mechanical strength of tablets. J. Pharm. Pharmacol. 33 (1981) 557-560
29. Varghese I., and Cetinkaya C. Non-contact photo-acoustic defect detection in drug tablets. J. Pharm. Sci. 96 (2007) 2125-2133
30. Waring M.J., Rubinstein M.H., and Howard J.R. Acoustic emission of pharmaceutical materials during compression. Int. J. Pharm. 36 (1987) 29-36
31. Wong D.Y.T., Waring M.J., Wright P., and Aulton M.E. Elucidation of the compressive deformation behavior of α-lactose monohydrate and anhydrous α-lactose single crystals by mechanical strength and acoustic emission analyses. Int. J. Pharm. 72 (1991) 233-241