Anti-inflammatory and analgesic activities of newly synthesized chiral peptide derivatives using (3-benzoyl-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethylester as starting material

Archiv der Pharmazie

Volumn 341, Issue 3, 2008, Pages 174-180

  Fakhr, Issa M ^a   Amr, Abdel Galil E ^a   Sabry, Nermien M ^a   Abdalah, Mohamed M ^b  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b Hi Care Pharmaceutical Co   (Egypt)

Author keywords

Amino acids; Analgesic agents; Anti inflammatory; Pyrrolidine 2,3 dione

Indexed keywords

(3 BENZOYL 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL)ACETIC ACID; (3 BENZOYL 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL)ACETIC ACID ETHYL ESTER; (3 BENZOYL 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL)ACETIC ACID HYDRAZIDE; 2 (3 BENZOYL 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL) N [6 [2 (3 BENZOYL 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL)ACETYLAMINO] 1,3,5,7 TETRAOXO 3,5,6,7 TETRAHYDRO 1H PYRROLO[3,4 F]ISOINDOL 2 YL]ACETAMIDE; 2 [2 (3 BENZOYL 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL)ACETYAMINO] 4 METHYL PENTANOIC ACID METHYL ESTER; 2 [2 (3 BENZOYL 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL)ACETYAMINO] 4 METHYLPENTANOIC ACID HYDRAZIDE; 2 [2 [2,3 DIOXO 5 PHENYL 4 [PHENYL (4,5,6,7 TETRACHLORO 1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YLIMINO)METHYL]PYRROLIDIN 1 YL]ACETYLAMINO] 4 METHYLPENTANOIC ACID (4,5,6,7 TETRACHLORO 1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YL)AMIDE; 2 [2,3 DIOXO 5 PHENYL 4 [PHENYL (4,5,6,7 TETRACHLORO 1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YLIMINO)METHYL]PYRROLIDIN 1 YL] N (4,5,6,7 TETRACHLORO 1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YL)ACETAMIDE; 3 (ETHYLTHIOSEMIHYDRAZINOPHENYLMETHYL 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL)ACETIC ACID N' THIOPROPIONYLHYDRAZIDE; [3 (HYDRAZINOPHENYLMETHYL) 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL]ACETIC ACID HYDRAZIDE; [3 [[(4 FLUOROBENZYLIDENE)HYDRAZONO]PHENYLMETHYL] 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL]ACETIC ACID (4 FLUOROBENZYLIDINE)HYDRAZIDE; [3 [[(4 METHYLBENZYLIDENE)HYDRAZONO]PHENYLMETHYL] 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL]ACETIC ACID (4 METHYLBENZYLIDINE)HYDRAZIDE; ACETIC ACID ETHYL ESTER; DICLOFENAC; HETEROCYCLIC COMPOUND; HYDRAZIDE DERIVATIVE; HYDRAZINE; N (1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YL) 2 [3 [(1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YLIMINO)PHENYLMETHYL] 4,5 DIOXO 2 PHENYLPYRROLIDIN 1 YL]ACETAMIDE; PEPTIDE DERIVATIVE; SODIUM HYDROXIDE; UNCLASSIFIED DRUG; VALDECOXIB; (3 BENZOYL 4,5 DIOXO 2 PHENYL PYRROLIDIN 1 YL)ACETIC ACID ETHYL ESTER; (3-BENZOYL-4,5-DIOXO-2-PHENYL-PYRROLIDIN-1-YL)ACETIC ACID ETHYL ESTER; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ISOXAZOLE DERIVATIVE; PYRROLIDINE DERIVATIVE; SULFONAMIDE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL REACTION; CHIRALITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HOT PLATE TEST; LD 50; MALE; MOUSE; NONHUMAN; PAW EDEMA; POLYMERIZATION; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; ANIMAL; COMPARATIVE STUDY; DOSE RESPONSE; SYNTHESIS; TOXICITY TESTING;

ACUTE TOXICITY TESTS; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; ISOXAZOLES; LETHAL DOSE 50; MALE; MICE; PYRROLIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 44649189800     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200700158     Document Type: Article

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