The l-amino acid carrier inhibitor 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) reduces l-dopa-elicited responses in dopaminergic neurons of the substantia nigra pars compacta

Experimental Neurology

Volumn 212, Issue 1, 2008, Pages 230-233

  Sebastianelli, Luca ^a,b   Ledonne, Ada ^b   Marrone, Maria Cristina ^b   Bernardi, Giorgio ^a,b   Mercuri, Nicola B ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

BCH; Dopamine; Electrophysiology; l dopa; l type amino acid transporters; Parkinson's disease; System L

Indexed keywords

2 AMINOBICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; LEVODOPA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; ELECTROPHYSIOLOGY; FEMALE; HYPERPOLARIZATION; MALE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; VOLTAGE CLAMP;

AMINO ACID TRANSPORT SYSTEM L; AMINO ACIDS; AMINO ACIDS, CYCLIC; ANIMALS; CARRIER PROTEINS; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; LEVODOPA; MALE; MEMBRANE POTENTIALS; NEURAL INHIBITION; NEURONS; RATS; RATS, WISTAR; SUBSTANTIA NIGRA;

EID: 44649170305     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2008.04.005     Document Type: Article

References (36)

1. Babu E., Kanai Y., Chairoungdua A., Kim D.K., Iribe Y., Tangtrongsup S., Jutabha P., Li Y., Ahmed N., Sakamoto S., Anzai N., Nagamori S., and Endou H. Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J. Biol. Chem. 278 44 (2003) 43838-43845 Oct 31
2. Boado R.J., Li J.Y., Nagaya M., Zhang C., and Pardridge W.M. Selective expression of the large neutral amino acid transporter at the blood-brain barrier. Proc. Natl. Acad. Sci. U.S.A. 12;96 21 (1999) 12079-12084
3. Bodoy S., Martin L., Zorzano A., Palacin M., Estevez R., and Bertran J. Identification of LAT4, a novel amino acid transporter with system L activity. J. Biol. Chem. 280 12 (2005) 12002-12011 Mar 25
4. Broer S., Broer A., and Hamprecht B. The 4F2hc surface antigen is necessary for expression of system L-like neutral amino acid-transport activity in C6-BU-1 rat glioma cells: evidence from expression studies in Xenopus laevis oocytes. Biochem. J. 312 Pt 3 (1995) 863-870 Dec 15
5. Brooks D.J., Ibanez V., Sawle G.V., Quinn N., Lees A.J., Mathias C.J., Bannister R., Marsden C.D., and Frackowiak R.S. Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Ann. Neurol. 28 4 (1990) 547-555 Oct
6. Christensen H.N., Handlogten M.E., Lam I., Tager H.S., and Zand R. A bicyclic amino acid to improve discriminations among transport systems. J. Biol. Chem. 244 6 (1969) 1510-1520 Mar 25
7. Duelli R., Enerson B.E., Gerhart D.Z., and Drewes L.R. Expression of large amino acid transporter LAT1 in rat brain endothelium. J. Cereb. Blood Flow Metab. 20 11 (2000) 1557-1562 Nov
8. Federici M., Sebastianelli L., Natoli S., Bernardi G., and Mercuri N.B. Electrophysiologic Changes in Ventral Midbrain Dopaminergic Neurons Resulting from (+/-)-3,4-Methylenedioxymethamphetamine (MDMA-"Ecstasy"). Biol. Psychiatry 62 6 (2007) 680-686 Sep 15
9. Fraga S., Serrao M.P., and Soares-da-Silva P. The l-3,4-dihydroxyphenylalanine transporter in human and rat epithelial intestinal cells is a type 2 hetero amino acid exchanger. Eur. J. Pharmacol. 441 3 (2002) 127-135 Apr 26
10. Gonon F.G., and Buda M.J. Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum. Neuroscience 14 3 (1985) 765-774 Mar
11. Grace A.A., and Bunney B.S. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons -1 Identification and characterization. Neuroscience 10 2 (1983) 301-315
12. Grace A.A., and Onn S.P. Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro. J. Neurosci. 9 10 (1989) 3463-3481 Oct
13. Grillner P., and Mercuri N.B. Intrinsic membrane properties and synaptic inputs regulating the firing activity of the dopamine neurons. Behav. Brain Res. 130 1-2 (2002) 149-169
14. Hawkins R.A., Mokashi A., and Simpson I.A. An active transport system in the blood-brain barrier may reduce levodopa availability. Exp. Neurol. 195 1 (2005) 267-271 Sep
15. Kageyama T., Imura T., Matsuo A., Minato N., and Shimohama S. Distribution of the 4F2 light chain, LAT1, in the mouse brain. NeuroReport 11 17 (2000) 3663-3666 Nov 27
16. Kanai Y., Segawa H., Miyamoto K., Uchino H., Takeda E., and Endou H. Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem. 273 37 (1998) 23629-23632 Sep 11
17. Kannari K., Tanaka H., Maeda T., Tomiyama M., Suda T., and Matsunaga M. Reserpine pretreatment prevents increases in extracellular striatal dopamine following l-DOPA administration in rats with nigrostriatal denervation. J. Neurochem. 74 1 (2000) 26326-26329 Jan
18. Katz I.R. Inhibition of 3,4-dihydroxy-l-phenylalanine decarboxylase in rat striatal synaptosomes by amino acids interacting with substrate transport. Biochim. Biophys. Acta. 600 1 (1980) 195-204 Jul 16
19. Keller Jr. R.W., Kuhr W.G., Wightman R.M., and Zigmond M.J. The effect of l-dopa on in vivo dopamine release from nigrostriatal bundle neurons. Brain Res. 447 1 (1988) 191-194
20. Lacey M.G., Mercuri N.B., and North R.A. Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta. J. Physiol. 392 (1987) 397-416
21. Mastroberardino L., Spindler B., Pfeiffer R., Skelly P.J., Loffing J., Shoemaker C.B., and Verrey F. Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature 395 6699 (1998) 288-291 Sep 17
22. Matsuo H., Tsukada S., Nakata T., Chairoungdua A., Kim D.K., Cha S.H., Inatomi J., Yorifuji H., Fukuda J., Endou H., and Kanai Y. Expression of a system L neutral amino acid transporter at the blood-brain barrier. NeuroReport 11 16 (2000) 3507-3511 Nov
23. McCormack A.L., and Di Monte D.A. Effects of l-dopa and other amino acids against paraquat-induced nigrostriatal degeneration. J. Neurochem. 85 1 (2003) 82-86 Apr
24. Mercuri N.B., and Bernardi G. The 'magic' of l-dopa: why is it the gold standard Parkinson's disease therapy?. Trends Pharmacol. Sci. 26 7 (2005) 341-344 Jul
25. Mercuri N.B., Calabresi P., and Bernardi G. Responses of rat substantia nigra compacta neurones to l-DOPA. Br J Pharmacol. Jun; 100 2 (1990) 257-260
26. Mercuri N.B., Bonci A., Calabresi P., Stefani A., and Bernardi G. Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons. Eur. J. Neurosci. 7 3 (1995) 462-469
27. Oxender D.L., and Christensen H.N. Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell. J. Biol. Chem. 238 (1963) 3686-3699 Nov
28. Pineda M., Fernandez E., Torrents D., Estevez R., Lopez C., Camps M., Lloberas J., Zorzano A., and Palacin M. Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an l-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J. Biol. Chem. 274 28 (1999) 19738-19744 Jul 9
29. Segawa H., Fukasawa Y., Miyamoto K., Takeda E., Endou H., and Kanai Y. Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity. J. Biol. Chem. 274 28 (1999) 19745-19751 Jul 9
30. Silva N.L., and Bunney B.S. Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine. Eur. J. Pharmacol. 149 3 (1988) 307-315
31. Sloan J.L., and Mager S. Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+). J. Biol. Chem. 274 34 (1999) 23740-23745 Aug 20
32. Smith Q.R., Nagura H., Takada Y., and Duncan M.W. Facilitated transport of the neurotoxin, beta-N-methylamino-l-alanine, across the blood-brain barrier. J. Neurochem. 58 4 (1992) 1330-1337 Apr
33. Soares-Da-Silva P., and Serrão M.P. Molecular modulation of inward and outward apical transporters of l-dopa in LLC-PK(1) cells. Am. J. Physiol., Renal. Physiol. 279 4 (2000) F736-F746
34. Wade L.A., and Katzman R. Synthetic amino acids and the nature of l-DOPA transport at the blood-brain barrier. J. Neurochem. 25 6 (1975) 837-842 Dec
35. Weissbach L., Handlogten M.E., Christensen H.N., and Kilberg M.S. Evidence for two Na+-independent neutral amino acid transport systems in primary cultures of rat hepatocytes. Time-dependent changes in activity. J. Biol. Chem. 257 20 (1982) 12006-12011 Oct 25
36. Yee R.E., Huang S.C., Togasaki D.M., Langston J.W., Satyamurthy N., and Barrio J.R. Imaging and therapeutics: the role of neuronal transport in the regional specificity of l-DOPA accumulation in brain. Mol. Imaging Biol. 4 3 (2002) 208-218 May