In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia

Journal of Steroid Biochemistry and Molecular Biology

Volumn 110, Issue 1-2, 2008, Pages 163-169

  Bacallao, K ^a   Leon, L ^a   Gabler, F ^a   Soto, E ^a   Romero, C ^a   Valladares, L ^b   Vega, M ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

Endometrial hyperplasia; PCOS; Proliferative endometrium; Steroid metabolic enzyme

Indexed keywords

AROMATASE; ESTROGEN SULFOTRANSFERASE; STERYL SULFATASE; TESTOSTERONE 17BETA DEHYDROGENASE;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOMETRIUM HYPERPLASIA; ENZYME ACTIVITY; ESTROGEN METABOLISM; FEMALE; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

17-HYDROXYSTEROID DEHYDROGENASES; ADULT; AROMATASE; ENDOMETRIAL HYPERPLASIA; ENDOMETRIUM; ESTROGENS; FEMALE; HUMANS; MIDDLE AGED; POLYCYSTIC OVARY SYNDROME; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STERYL-SULFATASE; SULFOTRANSFERASES;

EID: 44649145178     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2008.03.031     Document Type: Article

References (40)

1. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 Consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil. Steril. 81 1 (2004) 19-25
2. Sagle M., Bishop K., Ridley N., Alexander F.-M., Michel M., Bonney R.-C., Beard R.-W., and Franks S. Recurrent early miscarriage and polycystic ovaries. BMJ 297 6655 (1998) 1027-1028
3. Tulppala M., Stenman U.-H., Cacciatore B., and Ylikorkala O. Polycystic ovaries and levels of gonadotrophins and androgen in recurrent miscarriage: prospective study in 50 women. Br. J. Obstet. Gynaecol. 100 4 (1993) 348-352
4. Giudice L.-C. Endometrium in PCOS: implantation and predisposition to endocrine CA. Best Pract. Res. Clin. Endocrinol. Metab. 20 2 (2006) 235-244 (Review)
5. Pillay O.-C., Te Fong L.-F., Crow J.C., Benjamin E., Mould T., Atiomo W., Menon P.A., Leonard A.J., and Hardiman P. The association between polycystic ovaries and endometrial cancer. Hum. Reprod. 21 4 (2006) 924-929
6. Hardiman P., Pillay O.-C., and Atiomo W. Polycystic ovary syndrome and endometrial carcinoma. Lancet 361 9371 (2003) 1810-1812 (Review. Erratum in: Lancet, 362 (9389) (2003) 1082)
7. Ehrmann D.-A., Barnes R.-B., Rosenfield R.-L., Cavaghan M.-K., and Imperial J. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 22 1 (1999) 141-146
8. American College of Obstetricians and Gynecologists, ACOG practice bulletin. Polycystic ovary syndrome. Number 41, December 2002, Int. J. Gynaecol. Obstet. 80(3) (2003) 335-48.
9. Villavicencio A., Bacallao K., Avellaira C., Gabler F., Fuentes A., and Vega M. Androgen and estrogen receptors and co-regulators levels in endometria from patients with polycystic ovarian syndrome with and without endometrial hyperplasia. Gynecol. Oncol. 103 1 (2006) 307-314
10. Villavicencio A., Bacallao K., Gabler F., Fuentes A., Albornoz J., Casals A., and Vega M. Deregulation of tissue homeostasis in endometria from patients with polycystic ovarian syndrome with and without endometrial hyperplasia. Gynecol. Oncol. 104 2 (2007) 290-295
11. Pasqualini J.-R., Chetrite G., Blacker C., Feinstein M.-C., Delalonde L., Talbi M., and Maloche C. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients. J. Clin. Endocrinol. Metab. 81 4 (1996) 1460-1464
12. Sasano H., Suzuki T., Takeyama J., Utsunomiya H., Ito K., Ariga N., and Moriya T. 17-Beta-hydroxysteroid dehydrogenase in human breast and endometrial carcinoma. A new development in intracrinology. Oncology 59 Suppl. 1 (2000) 5-12 (Review)
13. Sasano H., and Harada N. Intratumoral aromatase in human breast, endometrial, and ovarian malignancies. Endocr. Rev. 19 5 (1998) 593-607
14. Simpson E.-R., Mahendroo M.-S., Means G.-D., Kilgore M.-W., Hinshelwood M.-M., Graham-Lorence S., Amarneh B., Ito Y., Fisher C.-R., Michael M.-D., et al. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr. Rev. 15 3 (1994) 342-355 (Review)
15. Reed M.-J., Purohit A., Woo L.-W., Newman S.-P., and Potter B.-V. Steroid sulfatase: molecular biology, regulation, and inhibition. Endocr. Rev. 26 (2005) 171-202
16. Strott C.-A. Sulfonation and molecular action. Endocr. Rev. 23 (2002) 703-732
17. Leon L., Bacallao K., Gabler F., Romero C., Valladares L., and Vega M. Activities of steroid metabolic enzymes in secretory endometria from untreated women with polycystic ovary syndrome. Steroids 73 (2008) 88-95
18. Dooley T.-P., Haldeman-Cahill R., Joiner J., and Wilborn T.-W. Expression profiling of human sulfotransferase and sulfatase gene superfamilies in epithelial tissues and cultured cells. Biochem. Biophys. Res. Commun. 277 1 (2000) 236-245
19. Sasano H., Suzuki T., Nakata T., and Moriya T. New development in intracrinology of breast carcinoma. Breast Cancer 13 2 (2006) 129-136 (Review)
20. Yamamoto T., Kitawaki J., Urabe M., Honjo H., Tamura T., Noguchi T., Okada H., Sasaki H., Tada A., Terashima Y., et al. Estrogen productivity of endometrium and endometrial cancer tissue; influence of aromatase on proliferation of endometrial cancer cells. J. Steroid Biochem. Mol. Biol. 44 4-6 (1993) 463-468
21. Mindnich R., Moller G., and Adamski J. The role of 17 beta-hydroxysteroid dehydrogenases. Mol. Cell. Endocrinol. 218 1-2 (2004) 7-20 (Review)
22. Luu-The V. Analysis and characteristics of multiple types of human 17β-hydroxysteroid dehydrogenase. J. Steroid Biochem. Mol. Biol. 76 1-5 (2001) 143-151
23. Kurman R.-J., Kaminski P.-F., and Norris H.-J. The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients. Cancer 56 2 (1985) 403-412
24. Noyes R.-W., Hertig A.-T., and Rock J. Dating the endometrial biopsy. Am. J. Obstet. Gynecol. 122 2 (1975) 262-263
25. Utsunomiya H., Ito K., Suzuki T., Kitamura T., Kaneko C., Nakata T., Niikura H., Okamura K., Yaegashi N., and Sasano H. Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma. Clin. Cancer Res. 10 17 (2004) 5850-5856
26. Miki Y., Nakata T., Suzuki T., Darnel A.-D., Moriya T., Kaneko C., Hidaka K., Shiotsu Y., Kusaka H., and Sasano H. Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues. J. Clin. Endocrinol. Metab. 87 12 (2002) 5760-5768
27. Yang S., Yang J., Liu J.-B., Wang H.-Y., Yang Q., Gao M., Liang Y.-H., Lin G.-S., Lin D., Hu X.-L., Fan L., and Zhang X.-J. The genetic epidemiology of alopecia areata in China. Br. J. Dermatol. 151 1 (2004) 16-23
28. Calle E.-E., and Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 4 8 (2004) 579-591 (Review)
29. Dheenadayalu K., Mak I., Gordts S., Campo R., Higham J., Puttemans P., White J., Christian M., Fusi L., and Brosens J. Aromatase P450 messenger RNA expression in eutopic endometrium is not a specific marker for pelvic endometriosis. Fertil. Steril. 78 4 (2002) 825-829
30. Johnson M.-C., Pinto C., Alves A., Palomino A., Fuentes A., Boric M.-A., and Vega M. P450Arom and estrogenic microenvironment of eutopic endometria in endometriosis. Rev. Med. Chil. 132 12 (2004) 1475-1482 (Spanish)
31. Noble L.-S., Simpson E.-R., Johns A., and Bulun S.-E. Aromatase expression in endometriosis. J. Clin. Endocrinol. Metab. 81 1 (1996) 174-179
32. Kitawaki J., Noguchi T., Amatsu T., Maeda K., Tsukamoto K., Yamamoto T., Fushiki S., Osawa Y., and Honjo H. Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium. Biol. Reprod. 57 3 (1997) 514-519
33. Watanabe K., Sasano H., Harada N., Ozaki M., Niikura H., Sato S., and Yajima A. Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in-situ hybridization, and biochemical studies. Am. J. Pathol. 146 2 (1995) 491-500
34. Ma X.-X., Zhang S.-L., Gao S., Lu J.-M., and Dong F. Expressions of aromatase protein and sex hormone receptor in endometrial lesions. Zhonghua Fu Chan Ke Za Zhi 41 6 (2006) 395-398
35. Van Landeghem A.-A., Poortman J., Nabuurs M., and Thijssen J.-H. Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res. 45 6 (1985) 2900-2906
36. Nakata T., Takashima S., Shiotsu Y., Murakata C., Ishida H., Akinaga S., Li P.-K., Sasano H., Suzuki T., and Saeki T. Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients. J. Steroid Biochem. Mol. Biol. 86 3-5 (2003) 455-460
37. Ruder H.J., Loriaux L., and Lipsett M.-B. Estrone sulfate: production rate and metabolism in man. J. Clin. Invest. 51 4 (1972) 1020-1033
38. Otsuka A.-Y., Andrade P.-M., Villanova F.-E., Borra R.-C., and Silva I.-D. Human endometrium mRNA profile assessed by oligonucleotide three-dimensional microarray. Gynecol. Endocrinol. August 20 (2007) 1-8
39. Ito K., Utsunomiya H., Suzuki T., Saitou S., Akahira J., Okamura K., Yaegashi N., and Sasano H. 17Beta-hydroxysteroid dehydrogenases in human endometrium and its disorders. Mol. Cell. Endocrinol. 248 1-2 (2006) 136-140 (Review)
40. Mustonen M.-V.-J., Isomaa V.-V., Vaskivuo T., Tapanainen J., Pautanen M.-H., Stenback F., Vieko R.-K., and Vihko P.-T. Human 17-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle. J. Clin. Endocrinol. Metab. 83 (1998) 1319-1324