Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABAA receptors and increases behavioral sensitivity to gaboxadol

Neuroscience Letters

Volumn 439, Issue 2, 2008, Pages 182-186

  Volgin, Denys V ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Development; Ethanol; GABA; Hypothalamus; Motor activity; Sleep

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; GABOXADOL; PROTEIN SUBUNIT;

ALCOHOL CONSUMPTION; ARTICLE; BRAIN DEVELOPMENT; BRAIN REGION; CONTROLLED STUDY; HYPOTHALAMUS; IMMUNOBLOTTING; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SLEEP; UPREGULATION;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUG INTERACTIONS; ETHANOL; GABA AGONISTS; HYPOTHALAMUS; ISOXAZOLES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RNA, MESSENGER; UP-REGULATION;

EID: 44649143794     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.05.011     Document Type: Article

References (43)

1. Alam M., Kumar S., Bashir T., Suntsova N., Methippara M., Szymusiak R., and McGinty D. GABA-mediated control of hypocretin- but not melanin-concentrating hormone-immunoreactive neurons during sleep in rats. J. Physiol. 563 (2005) 569-582
2. Allan A., Wu H., Paxton L., and Savage D. Prenatal ethanol exposure alters the modulation of the gamma-aminobutyric acid A1 receptor-gated chloride ion channel in adult rat offspring. J. Pharmacol. Exp. Ther. 284 (1998) 250-257
3. Allen G.C., West J.R., Chen W.J.A., and Earnest D.J. Developmental alcohol exposure disrupts circadian regulation of BDNF in the rat suprachiasmatic nucleus. Neurotoxicol. Teratol. 26 (2004) 353-358
4. A receptor subunit protein expression in the adult guinea pig cerebral cortex. J. Neurosci. 21 (2001) 4381-4389
5. A receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol. Eur. J. Pharmacol. 541 (2006) 158-162
6. Borghese C., and Harris R. Studies of ethanol actions on recombinant delta-containing gamma-aminobutyric acid type A receptors yield contradictory results. Alcohol 41 (2007) 155-162
7. D'Angiulli A., Grunau P., Maggi S., and Herdman A. Electroencephalographic correlates of prenatal exposure to alcohol in infants and children: a review of findings and implications for neurocognitive development. Alcohol 40 (2006) 127-133
8. De A., Mukherjee S., Krueger J.M., and Simasko S.M. Prenatal ethanol exposure changes non rapid eye movement sleep in adult male rats. Sleep 28 (2005) A31-A131
9. Dobbing J., and Sands J. Comparative aspects of the brain growth spurt. Early Hum. Dev. 3 (1979) 79-83
10. Farnell Y.Z., West J.R., Chen W.J.A., Allen G.C., and Earnest D.J. Developmental alcohol exposure alters light-induced phase shifts of the circadian activity rhythm in rats. Alcohol Clin. Exp. Res. 28 (2004) 1020-1027
11. Flugge G., Wuttke W., and Fuchs E. Postnatal development of transmitter systems-sexual-differentiation of the GABAergic system and effects of muscimol. Int. J. Dev. Neurosci. 4 (1986) 319-326
12. Goodlett C., and Johnson T. Neonatal binge ethanol exposure using intubation: timing and dose effects on place learning. Neurotoxicol. Teratol. 19 (1997) 435-446
13. Havlicek V., Childiaeva R., and Chernick V. EEG frequency spectrum characteristics of sleep states in infants of alcoholic mothers. Neuropediatrics 8 (1977) 360-373
14. Hsiao S.H., Parrish A.R., Nahm S.S., Abbott L.C., McCool B.A., and Frye G.D. Effects of early postnatal ethanol intubation on GABAergic synaptic proteins. Dev. Brain Res. 138 (2002) 177-185
15. Ioffe S., and Chernick V. Prediction of subsequent motor and mental retardation in newborn infants exposed to alcohol in utero by computerized EEG analysis. Neuropediatrics 21 (1990) 11-17
16. Johnson T., and Goodlett C. Selective and enduring deficits in spatial learning after limited neonatal binge alcohol exposure in male rats. Alcohol Clin. Exp. Res. 26 (2002) 83-93
17. Karlsson K., Kreider J., and Blumberg M. Hypothalamic contribution to sleep-wake cycle development. Neuroscience 123 (2004) 575-582
18. Light K., Kane C., Pierce D., Jenkins D., Ge Y., Brown G., Yang H., and Nyamweya N. Intragastric intubation: important aspects of the model for administration of ethanol to rat pups during the postnatal period. Alcohol Clin. Exp. Res. 22 (1998) 1600-1606
19. Lu J., Greco M., Shiromani P., and Saper C. Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep. J. Neurosci. 20 (2000) 3830-3842
20. J. Lu, C. Scnchez, C. Saper, V. Vogel, Gaboxadol activates endogenous sleep control mechanism, Program No. 617.1, Washington, DC, 2003 Abstract Viewer/Itinerary Planner, Soc. Neurosci.
21. O'Leary-Moore S., McMechan A., Mathison S., Berman R., and Hannigan J. Reversal learning after prenatal or early postnatal alcohol exposure in juvenile and adult rats. Alcohol 38 (2006) 99-110
22. Ohno K., and Sakurai T. Orexin neuronal circuitry: role in the regulation of sleep and wakefulness. Front. Neuroendocrinol. 29 (2008) 70-87
23. Owens D.F., and Kriegstein A.R. Is there more to GABA than synaptic inhibition?. Nat. Rev. Neurosci. 3 (2002) 715-727
24. A receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101 (2000) 815-850
25. Riley E., and McGee C. Fetal alcohol spectrum disorders: an overview with emphasis on changes in brain and behavior. Exp. Biol. Med. 230 (2005) 357-365
26. A receptors. J. Neurochem. 105 (2008) 338-350
27. Sallanon M., Denoyer M., Kitahama K., Aubert C., Gay N., and Jouvet M. Long-lasting insomnia induced by preoptic neuron lesions and its transient reversal by muscimol injection into the posterior hypothalamus in the cat. Neuroscience 32 (1989) 669-683
28. Schwartz M., Sipols A., Grubin C., and Baskin D. Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase. Brain Res. Bull. 31 (1993) 361-367
29. A and glycine receptor-mediated synaptic currents in brain stem motoneurons. J. Neurophysiol. 90 (2003) 870-875
30. A receptor subtypes. Adv. Pharmacol. 54 (2006) 231-263
31. Spear L.P., Penson J., and Linville D.G. GABA and behavioral inhibition in the neonatal rat pup. Psychopharmacology (Berlin) 90 (1986) 106-111
32. Steininger T., Gong H., McGinty D., and Szymusiak R. Subregional organization of preoptic area/anterior hypothalamic projections to arousal-related monoaminergic cell groups. J. Comp. Neurol. 429 (2001) 638-653
33. Stone W., Altman H., Hall J., Arankowsky-Sandoval G., Parekh P., and Gold P. Prenatal exposure to alcohol in adult rats: relationships between sleep and memory deficits, and effects of glucose administration on memory. Brain Res. 742 (1996) 98-106
34. A receptors are a target for alcohol. Nat. Neurosci. 5 (2002) 721-722
35. Sylvester L., Kapron C., and Smith C. In utero ethanol exposure decreases rapid eye movement sleep in female Sprague-Dawley rat offspring. Neurosci. Lett. 289 (2000) 13-16
36. Szymusiak R., Alam N., Steininger T.L., and McGinty D. Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats. Brain Res. 803 (1998) 178-188
37. A receptor subunit mRNAs are differentially regulated in the hypothalamic perifornical region in association with sleep loss and circadian time. Sleep 26 Suppl. (2003) A38-A39
38. A receptor mRNA in vitro. Biochem. Biophys. Res. Commun. 353 (2007) 726-732
39. Wagner A., and Hunt P. Impaired trace fear conditioning following neonatal ethanol: reversal by choline. Behav. Neurosci. 120 (2006) 482-487
40. Wallner M., Hanchar H., and Olsen R. Ethanol enhances α4β3δ and α6β3δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 15218-15223
41. A δ-subunit-containing receptors. Eur. J. Neurosci. 25 (2007) 1893-1899
42. Worst T., and Vrana K. Alcohol and gene expression in the central nervous system. Alcohol Alcoholism 40 (2005) 63-75
43. Zeder-Lutz G., Cherouati N., Reinhart C., Pattus F., and Wagner R. Dot-blot immunodetection as a versatile and high-throughput assay to evaluate recombinant GPCRs produced in the yeast Pichia pastoris. Protein Expr. Purif. 50 (2006) 118-127