Occurrence and cellular localization of PrPd in kidneys of scrapie-affected sheep in the absence of inflammation

Journal of Pathology

Volumn 215, Issue 2, 2008, Pages 126-134

  Siso S ^a   Jeffrey, M ^a   Steele, P ^b   McGovern, G ^a   Martin, S ^a   Finlayson, J ^b   Chianini, F ^b   Gonzalez L ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

^b MOREDUN RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Kidney; Prion; Renal pathogenesis; Scrapie; Sheep

Indexed keywords

AMINO ACID; CELL MARKER; COLLAGEN; PRION PROTEIN; PROTEIN ANTIBODY; R145 ANTIBODY;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BLOOD; CADAVER; CELL MEMBRANE; CELLULAR DISTRIBUTION; EXTRAVASATION; FIBROBLAST; GLOMERULUS FILTRATION; HENLE LOOP; HISTOLOGY; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; KIDNEY; KIDNEY INTERSTITIUM; KIDNEY PAPILLA; LYSOSOME; NEPHRITIS; NONHUMAN; PATHOGENESIS; POLLUTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; RETICULOENDOTHELIAL SYSTEM; SCRAPIE; SHEEP; ULTRASTRUCTURE; URINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL MEMBRANE; CYTOPLASM; EXTRACELLULAR MATRIX; GENOTYPE; IMMUNOHISTOCHEMISTRY; KIDNEY; MICROSCOPY, ELECTRON; PRPSC PROTEINS; SCRAPIE; SHEEP;

EID: 44649133884     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2336     Document Type: Article

References (34)

1. Jeffrey M, González L, Espenes A, Press CM, Martin S, Chaplin M, et al. Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep. J Pathol 2006;209:4-14.
2. Van Keulen LJM, Schreuder BEC, Vromans MEW, Langeveld JPM, Smits MA, van Keulen LJM, et al. Pathogenesis of natural scrapie in sheep. In Prion Diseases and Pathogenesis, Kretzschmar H (ed). Springer-Verlag: Vienna, 2000; 57-71.
3. Hunter N, Foster J, Chong A, McCutcheon S, Parnham D, Eaton S, et al. Transmission of prion diseases by blood transfusion. J Gen Virol 2002;83:2897-2905.
4. Sisó S, González L, Houston F, Hunter N, Martin S, Jeffrey M. The neuropathologic phenotype of experimental ovine BSE is not altered after blood transfusion. Blood 2006;108:745-748.
5. Jeffrey M, Martin S, Thomson JR, Dingwall WS, Begara-McGorum I, Gonzalez L. Onset and distribution of tissue PrP accumulation in scrapie-affected Suffolk sheep as demonstrated by sequential necropsies and tonsillar biopsies. J Comp Pathol 2001;125:48-57.
6. Andréoletti O, Lacroux C, Chabert A, Monnereau L, Tabouret G, Lantier F, et al. PrP(Sc) accumulation in placentas of ewes exposed to natural scrapie: influence of foetal prp genotype and effect on ewe-to-lamb transmission. J Gen Virol 2002;83:2607-2616.
7. Andréoletti O, Simon S, Lacroux C, Morel N, Tabouret G, Chabert A, et al. PrPsc accumulation in myocytes from sheep incubating natural scrapie. Nature Med 2004;10:591-593.
8. Vascellari M, Nonno R, Mutinelli F, Bigolaro M, Di Bari MA, Melchiotti E, et al. PrPsc in salivary glands of scrapie-affected sheep. J Virol 2007;81:4872-4876.
9. Ligios C, Sigurdson CJ, Santucciu C, Carcassola G, Manco G, Basagni M, et al. PrPsc in mammary glands of sheep affected by scrapie and mastitis. Nature Med 2005;11:1137-1138.
10. Sisó S, González L, Jeffrey M, Martin S, Chianini F, Steele P. Prion protein in kidneys of scrapie-infected sheep (Letter). Vet Rec 2006;159:327-328.
11. Ligios C, Cancedda GM, Margalith I, Santucciu C, Madau L, Maestrale C, et al. Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep. PLoS ONE 2007;DOI:10.1371/journal.pone.0000859.
12. Race R, Jenny A, Sutton D. Scrapie infectivity and proteinase K-resistant prion protein in sheep placenta, brain, spleen, and lymph node: implications for transmission and antemortem diagnosis. J Infect Dis 1998;178:949-953.
13. Piccardo P, Manson JC, King D, Ghetti B, Barron RM. Accumulation of prion protein in the brain that is not associated with transmissible disease. PNAS 2007;104:4712-4717.
14. Hadlow WJ, Kennedy RC, Race RE. Natural infection of Suffolk sheep with scrapie virus. J Infect Dis 1982;146:657-664.
15. Hourrigan JL. Epidemiology of scrapie in the United States. Proc Annu Meet U S Anim Health Assoc 1988;92:386-401.
16. Ryder S, Dexter G, Bellworthy S, Tongue S. Demonstration of lateral transmission of scrapie between sheep kept under natural conditions using lymphoid tissue biopsy. Res Vet Sci 2004;76:211-217.
17. McGovern G, Brown KL, Bruce ME, Jeffrey M. Murine scrapie infection causes an abnormal germinal centre reaction in the spleen. J Comp Pathol 2004;130:181-194.
18. González L, Martin S, Begara-McGorum I, Hunter N, Houston F, Simmons M, et al. Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie. J Comp Pathol 2002;126:17-29.
19. González L, Martin S, Houston FE, Hunter N, Reid HW, Bellworthy SJ, et al. Phenotype of disease-associated PrP accumulation in the brain of bovine spongiform encephalopathy experimentally infected sheep. J Gen Virol 2005;86:827-838.
20. Martin S, González L, Chong A, Houston FE, Hunter N, Jeffrey M. Immunohistochemical characteristics of disease-associated prp are not altered by host genotype or route of infection following infection of sheep with bovine spongiform encephalopathy. J Gen Virol 2005;86:839-848.
21. Jeffrey M, González L, Chong A, Foster J, Goldmann W, Hunter N, et al. Ovine infection with the agents of scrapie (CH1641 isolate) and bovine spongiform encephalopathy: immunochemical similarities can be resolved by immunohistochemistry. J Comp Pathol 2006;134:17-29.
22. Jeffrey M, Martin S, González L. Cell-associated variants of disease-specific prion protein immunolabelling are found in different sources of sheep transmissible spongiform encephalopathy. J Gen Virol 2003;84:1033-1045.
23. Jeffrey M, Martin S, González L, Foster J, Langeveld JP, van Zijderveld FG, et al. Immunohistochemical features of PrP(d) accumulation in natural and experimental goat transmissible spongiform encephalopathies. J Comp Pathol 2006;134:171-181.
24. O'Rourke KI, Zhuang D, Lyda A, Gomez G, Williams ES, Tuo W, et al. Abundant prp(CWD) in tonsil from mule deer with preclinical chronic wasting disease. J Vet Diagn Invest 2003;15:320-323.
25. Brun A, Castilla J, Ramirez MA, Prager K, Parra B, Salguero FJ, et al. Proteinase K enhanced immunoreactivity of the prion protein-specific monoclonal antibody 2A11. Neurosci Res 2004;48:75-83.
26. Hopkins J, Dutia BM, McConnell I. Monoclonal antibodies to sheep lymphocytes. I. Identification of MHC class II molecules on lymphoid tissue and changes in the level of class II expression on lymph-borne cells following antigen stimulation in vivo. Immunology 1986;59:433-438.
27. Lezmi S, Bencsik A, Monks E, Petit T, Baron T. First case of feline spongiform encephalopathy in a captive cheetah born in France: prp(sc) analysis in various tissues revealed unexpected targeting of kidney and adrenal gland. Histochem Cell Biol 2003;119:415-422.
28. Ryder SJ, Wells GA, Bradshaw JM, Pearson GR. Inconsistent detection of prp in extraneural tissues of cats with feline spongiform encephalopathy. Vet Rec 2001;148:437-441.
29. Vorberg I, Raines A, Story B, Priola SA. Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents. J Infect Dis 2004;189:431-439.
30. Heikenwalder M, Zeller N, Seeger H, Prinz M, Klohn PC, Schwarz P, et al. Chronic lymphocytic inflammation specifies the organ tropism of prions. Science 2005;307:1107-1110.
31. Hope J, Morton LJ, Farquhar CF, Multhaup G, Beyreuther K, Kimberlin RH. The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (prp). EMBO J 1986;5:2591-2597.
32. Murayama Y, Yoshioka M, Okada H, Takata M, Yokoyama T, Mohri S. Urinary excretion and blood level of prions in scrapie-infected hamsters. J Gen Virol 2007;88:2890-2898.
33. Amselgruber WM, Steffl M, Didier A, Märtlbauer E, Pfaff E, Büttner M. Prion protein expression in bovine podocytes and extraglomerular mesangial cells. Cell Tissue Res 2006;324:497-505.
34. Apetri AC, Surewicz WK. Atypical effect of salts on the thermodynamic stability of human prion protein. J Biol Chem 2003;278:22187- 22192.