Characterization of chlorhexidine-releasing, fast-setting, brushite bone cements

Acta Biomaterialia

Volumn 4, Issue 4, 2008, Pages 1081-1088

  Young, Anne M ^a   Ng, Poon Yun J ^a   Gbureck, Uwe ^b   Nazhat, Showan N ^c   Barralet, Jake E ^c   Hofmann, Michael P ^d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Brushite; Chlorhexidine; Drug cement interaction; Drug release; Setting kinetics

Indexed keywords

CONTROLLED DRUG DELIVERY; KINETICS; MAPPING; TARGETED DRUG DELIVERY; ULTRAVIOLET SPECTROSCOPY;

ANTIBACTERIALS; BRUSHITE; CHLORHEXIDINE; CHLORHEXIDINE DIACETATE; DRUG CEMENT INTERACTION; DRUG RELEASE; FAST SETTING; RAMAN MAPPING; SETTING KINETICS; TRI-CALCIUM PHOSPHATES;

FOURIER TRANSFORM INFRARED SPECTROSCOPY;

BONE CEMENT; CALCIUM PHOSPHATE; CALCIUM PHOSPHATE DIBASIC; CHLORHEXIDINE ACETATE; WATER;

ARTICLE; CONCENTRATION RESPONSE; DIFFUSION; DRUG RELEASE; FOURIER TRANSFORM MASS SPECTROMETRY; GRAVIMETRY; KINETICS; MONITORING; POWDER; PRIORITY JOURNAL; RAMAN SPECTROMETRY; TEMPERATURE;

EID: 44549083233     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2007.12.009     Document Type: Article

References (30)

1. Bohner M. Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements. Injury 31 (2000) 37-47
2. Bohner M., Gbureck U., and Barralet J.E. Technological issues for the development of more efficient calcium phosphate bone cements: a critical assessment. Biomaterials 26 (2005) 6423-6429
3. Mirtchi A.A., Lemaitre J., and Terao N. Calcium phosphate cements: study of the beta-tricalcium phosphate-monocalcium phosphate system. Biomaterials 10 (1989) 475-480
4. Bohner M., Merkle H.P., van Landuyt P., Trophardy G., and Lemaitre J. Effect of several additives and their admixtures on the physico-chemical properties of calcium phosphate cement. J Mater Sci: Mater Med 11 (2000) 111-116
5. 7 system. J Am Ceram Soc 88 (2005) 3096-3103
6. Grover L.M., Gbureck U., Young A.M., Wright A.J., and Barralet J.E. Temperature dependent setting kinetics and mechanical properties of beta-TCP-pyrophosphoric acid bone cement. J Mater Chem 15 (2005) 4955-4962
7. Barralet J.E., Grover L.M., and Gbureck U. Ionic modification of calcium phosphate cement viscosity Part II: hypodermic injection and strength improvement of brushite cement. Biomaterials 25 (2004) 2197-2203
8. Lilley K.J., Gbureck U., Wright A.J., Knowles J.C., Farrar D.F., and Barralet J.E. Brushite cements from polyphosphoric acid, calcium phosphate systems. J Am Ceram Soc 90 (2007) 1892-1898
9. Ginebra M.P., Traykova T., and Planell J.A. Calcium phosphate cements: Competitive drug carriers for the musculoskeletal system?. Biomaterials 27 (2006) 2171-2177
10. Ginebra M.P., Traykova T., and Planell J.A. Calcium phosphate cements as bone drug delivery systems: a review. J Control Release 113 (2006) 102-110
11. Schnieders J., Gbureck U., Thull R., and Kissel T. Controlled release of gentamicin from calcium phosphate-poly(lactic acid-co-glycolic acid) composite bone cement. Biomaterials 27 (2006) 4239-4249
12. Bohner M., Lemaitre J., Merkle H.P., and Gander B. Control of gentamicin release from a calcium phosphate cement by admixed poly(acrylic acid). J Pharm Sci 89 (2000) 1262-1270
13. Bohner M., Lemaitre J., van Landuyt P., Zambelli P.Y., Merkle H.P., and Gander B. Gentamicin-loaded calcium phosphate bone cement as antibiotic delivery system. J Pharm Sci 86 (1997) 565-572
14. Tzafriri A.R. Mathematical modeling of diffusion-mediated release from bulk degrading matrices. J Control Release 63 (2000) 69-79
15. TM) in periodontal maintenance patients. J Clin Periodontol 28 (2001) 90-95
16. Leung D., Spratt D.A., Pratten J., Gulabivala K., Mordan N.J., and Young A.M. Chlorhexidine-releasing methacrylate dental composite materials. Biomaterials 26 (2005) 7145-7153
17. Anusavice K.J., Zhang N.Z., and Shen C. Controlled release of chlorhexidine from UDMA-TEGDMA resin. J Dent Res 85 (2006) 950-954
18. Young AM, Leung D, Ho SM, Sheung YT, Pratten J, Spratt DA. New injectable antibacterial composites for bone and tooth repair. In: Medical polymers 2004. Shawbury, Shropshire: Rapra Technology Ltd; 2004. p. 147-58.
19. Hofmann M.P., Young A.M., Gbureck U., Nazhat S.N., and Barralet J.E. FTIR-monitoring of a fast setting brushite bone cement: effect of intermediate phases. J Mater Chem 16 (2006) 3199-3206
20. Bohner M., Lemaitre J., and Ring T.A. Effects of sulfate, pyrophosphate, and citrate ions on the physicochemical properties of cements made of beta-tricalcium phosphate-phosphoric acid-water mixtures. J Am Ceram Soc 79 (1996) 1427-1434
21. Gbureck U., Grolms O., Barralet J.E., Grover L.M., and Thull R. Mechanical activation of β-TCP. Biomaterials 24 (2003) 4123-4131
22. Hofmann M.P., Nazhat S.N., Gbureck U., and Barralet J.E. Real-time monitoring of the setting reaction of brushite-forming cement using isothermal differential scanning calorimetry. J Biomed Mater Res Part B: Appl Biomater 79 (2006) 360-364
23. Crank J. Mathematics of diffusion. 2nd ed. (1957), Oxford University Press, New York
24. Noiri Y., Okami Y., Narimatsu M., Takahashi Y., Kawahara T., and Ebisu S. Effects of chlorhexidine, minocycline, and metronidazole on porphyromonas gingivalis strain 381 in biofilms. J Periodontol 74 (2003) 1647-1651
25. (TM) in the gingival crevicular fluid, plasma and urine. J Clin Periodontol 25 (1998) 1017-1021
26. Schwach-Abdellaoui K., Vivien-Castioni N., and Gurny R. Local delivery of antimicrobial agents for the treatment of periodontal diseases. Eur J Pharm Biopharm 50 (2000) 83-99
27. Wilson M., Patel H., and Fletcher J. Susceptibility of biofilms of Streptococcus sanguis to chlorhexidine gluconate and cetylpyridinium chloride. Oral Microbiol Immun 11 (1996) 188-192
28. Daneshmand N., Jorgensen M.G., Nowzari H., Morrison J.L., and Slots J. Initial effect of controlled release chlorhexidine on subgingival microorganisms. J Periodont Res 37 (2002) 375-379
29. Salvi G.E., Mombelli A., Mayfield L., Rutar A., Suvan J., Garrett S., et al. Local antimicrobial therapy after initial periodontal treatment-a randomized clinical trial comparing three biodegradable sustained release polymers. J Clin Periodont 29 (2002) 540-550
30. Jones D.S., Brown A.F., Woolfson D., Dennis A.C., Matchett L.J., and Bell S.E.J. Examination of the physical state of chlorhexidine within viscoelastic, bioadhesive semisolids using Raman spectroscopy. J Pharm Sci 89 (2000) 563-571