Semiquantitative measurement of murine bleomycin-induced lung fibrosis in in vivo and postmortem conditions using microcomputed tomography: Correlation with pathologic scores - Initial results

Investigative Radiology

Volumn 43, Issue 6, 2008, Pages 453-460

  Lee, Hyun Ju ^a   Goo, Jin Mo ^a   Kim, Na Ra ^a   Kim, Min A ^a   Chung, Doo Hyun ^a   Son, Kyu Ri ^a   Kim, Hyo Cheol ^a   Lee, Chang Hyun ^a   Park, Chang Min ^a   Chun, Eun Ju ^a   Im, Jung Gi ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

Bleomycin; Fibrosis; Lung; Microcomputed tomography; Murine

Indexed keywords

BLEOMYCIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; C57BL 6 MOUSE; CADAVER; CONTROLLED STUDY; CORRELATION COEFFICIENT; FEMALE; FOLLOW UP; HISTOPATHOLOGY; IN VIVO STUDY; INFLAMMATION; LUNG FIBROSIS; LUNG PARENCHYMA; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANK SUM TEST; SCORING SYSTEM; STATISTICAL ANALYSIS;

EID: 44449174438     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/RLI.0b013e31816900ec     Document Type: Article

References (34)

1. Paulus MJ, Gleason SS, Kennel SJ, et al. High resolution X-ray computed tomography: an emerging tool for small animal cancer research. Neoplasia. 2000;2:62-70.
2. Paulus MJ, Gleason SS, Easterly ME, et al. A review of high-resolution X-ray computed tomography and other imaging modalities for small animal research. Lab Anim (NY). 2001;30:36-45.
3. Hoffman JM, Croft BY. Future directions in small animal imaging. Lab Anim (NY). 2001;30:32-35.
4. Coultas DB, Zumwalt RE, Black WC, et al. The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med. 1994;150:967-972.
5. Phan SH. New strategies for treatment of pulmonary fibrosis. Thorax. 1995;50:415-421.
6. Mason RJ, Schwarz MI, Hunninghake GW, et al. NHLBI workshop summary. pharmacological therapy for idiopathic pulmonary fibrosis. Past, present, and future. Am J Respir Crit Care Med. 1999;160:1771-1777.
7. Yaekashiwa M, Nakayama S, Ohnuma K, et al. Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study. Am J Respir Crit Care Med. 1997;156:1937-1944.
8. Gunther A, Lubke N, Ermert M, et al. Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits. Am J Respir Crit Care Med. 2003;168:1358-1365.
9. Daniels CE, Wilkes MC, Edens M, et al. Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J Clin Invest. 2004;114:1308-1316.
10. Kim JH, Kim HY, Kim S, et al. Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma. Am J Pathol. 2005;167:1231-1241.
11. Aono Y, Nishioka Y, Inayama M, et al. Imatinib as a novel antifibrotic agent in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med. 2005;171:1279-1285.
12. Keogh KA, Standing J, Kane GC, et al. Angiotensin II antagonism fails to ameliorate bleomycin-induced pulmonary fibrosis in mice. Eur Respir J. 2005;25:708-714.
13. Inayama M, Nishioka Y, Azuma M, et al. A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med. 2006;173:1016-1022.
14. Hutson PR, Crawford ME, Sorkness RL. Liquid chromatographic determination of hydroxyproline in tissue samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;791:427-430.
15. Izbicki G, Segel MJ, Christensen TG, et al. Time course of bleomycin-induced lung fibrosis. Int J Exp Pathol. 2002;83:111-119.
16. Plathow C, Li M, Gong P, et al. Computed tomography monitoring of radiation-induced lung fibrosis in mice. Invest Radiol. 2004;39:600-609.
17. Cavanaugh D, Travis EL, Price RE, et al. Quantification of bleomycin-induced murine lung damage in vivo with micro-computed tomography. Acad Radiol. 2006;13:1505-1512.
18. Kazerooni EA, Martinez FJ, Flint A, et al. Thin-section CT obtained at 10-mm increments versus limited three-level thin-section CT for idiopathic pulmonary fibrosis: correlation with pathologic scoring. AJR Am J Roentgenol. 1997;169:977-983.
19. Cherniack RM, Colby TV, Flint A, et al. Quantitative assessment of lung pathology in idiopathic pulmonary fibrosis. The BAL Cooperative Group Steering Committee. Am Rev Respir Dis. 1991;144:892-900.
20. Brennan P, Silman A. Statistical methods for assessing observer variability in clinical measures. BMJ. 1992;304:1491-1494.
21. Cavanaugh D, Johnson E, Price RE, et al. In vivo respiratory-gated micro-CT imaging in small-animal oncology models. Mol Imaging. 2004;3:55-62.
22. Doherty DE, Hirose N, Zagarella L, et al. Prolonged monocyte accumulation in the lung during bleomycin-induced pulmonary fibrosis. A noninvasive assessment of monocyte kinetics by scintigraphy. Lab Invest. 1992;66:231-242.
23. Shen AS, Haslett C, Feldsien DC, et al. The intensity of chronic lung inflammation and fibrosis after bleomycin is directly related to the severity of acute injury. Am Rev Respir Dis. 1988;137:564-571.
24. Rossi SE, Erasmus JJ, McAdams HP, et al. Pulmonary drug toxicity: radiologic and pathologic manifestations. Radiographics. 2000;20:1245-1259.
25. Padley SP, Adler B, Hansell DM, et al. High-resolution computed tomography of drug-induced lung disease. Clin Radiol. 1992;46:232-236.
26. Balazs G, Noma S, Khan A, et al. Bleomycin-induced fibrosis in pigs: evaluation with CT. Radiology. 1994;191:269-272.
27. Harrison JH Jr, Lazo JS. High dose continuous infusion of bleomycin in mice: a new model for drug-induced pulmonary fibrosis. J Pharmacol Exp Ther. 1987;243:1185-1194.
28. Snider GL, Hayes JA, Korthy AL. Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin: pathology and stereology. Am Rev Respir Dis. 1978;117:1099-1108.
29. Hesterberg TW, Gerriets JE, Reiser KM, et al. Bleomycin-induced pulmonary fibrosis: correlation of biochemical, physiological, and histological changes. Toxicol Appl Pharmacol. 1981;60:360-367.
30. Lindenschmidt RC, Tryka AF, Godfrey GA, et al. Intratracheal versus intravenous administration of bleomycin in mice: acute effects. Toxicol Appl Pharmacol. 1986;85:69-77.
31. Bartling SH, Stiller W, Grasruck M, et al. Retrospective motion gating in small animal CT of mice and rats. Invest Radiol. 2007;42:704-714.
32. Ley-Zaporozhan J, Ley S, Unterhinninghofen R, et al. Quantification of lung volume at different tidal volumes and positive end-expiratory pressures in a porcine model by using retrospective respiratory gated 4D-computed tomography. Invest Radiol. 2008;43:461-469.
33. Boss A, Schaefer S, Martirosian P, et al. Magnetic resonance imaging of lung tissue: influence of body positioning, breathing and oxygen inhalation on signal decay using multi-echo gradient-echo sequences. Invest Radiol. 2008;43:433-438.
34. Scadeng M, Rossiter HB, Dubowitz DJ, et al. High-resolution three-dimensional magnetic resonance imaging of mouse lung in situ. Invest Radiol. 2007;42:50-57.