Sedation and analgesia in the PICU: Many questions remain

Intensive Care Medicine

Volumn 32, Issue 8, 2006, Pages 1103-1105

  Prins, Sandra ^a   Van Dijk, Monique ^a   Tibboel, Dick ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; MORPHINE; NALOXONE; PROPOFOL;

ANALGESIA; ANXIETY DISORDER; ARTIFICIAL VENTILATION; BISPECTRAL INDEX; CAREGIVER; CHILD; CRITICAL ILLNESS; DISTRESS SYNDROME; EDITORIAL; HUMAN; INTENSIVE CARE; NONHUMAN; PAIN ASSESSMENT; PROPOFOL INFUSION SYNDROME; SEDATION; SIDE EFFECT; SOMNOLENCE;

ANALGESIA; CHILD; CONSCIOUS SEDATION; CRITICAL ILLNESS; HUMANS; INTENSIVE CARE UNITS, PEDIATRIC; RANDOMIZED CONTROLLED TRIALS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 33747194655     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-006-0191-9     Document Type: Editorial

References (16)

1. Playfor S, Jenkins I, Boyles C, Choonara I, Davies G, Haywood T, Hinson G, Mayer H, Morton NS, Ralph T, Wolf A (2006) Consensus guidelines on sedation and analgesia in critically ill children. Intensive Care Med DOI 10.1007/s00134-0190-x
2. Carcillo JA, Doughty L, Kofos D, Frye RF, Kaplan SS, Sasser H, Burckart GJ (2003) Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive Care Med 29:980-984
3. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE (2003) Developmental pharmacology: drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157-1167
4. van Dijk M, Bouwmeester J, Koot HM, Boer de JB, Passchier J, Tibboel D (2002) Efficacy of continuous versus intermittent morphine administration after major surgery in 0 to 3-year old infants: a double-blind randomised controlled trial. Pain 98:298-306
5. Prins SA, Peeters MYM, Houmes RJ, van Dijk M, Knibbe CAJ, Danhof M, Tibboel D (2005) Propofol 6% as sedative in children under 2 years of age following major craniofacial surgery. Br J Anaesth 94:630-635
6. Symington A, Pinelli J (2003) Developmental care for promoting development and preventing morbidity in preterm infants. Cochrane Database Syst Rev CD001814
7. Arenas-Lopez S, Riphagen S, Tibby SM, Durward A, Tomlin S, Davies G, Murdoch IA (2004) Use of oral clonidine for sedation in ventilated paediatric intensive care patients. Intensive Care Med 30:1625-1629
8. Courtman SP, Wardurgh A, Petros AJ (2003) Comparison of the bispectral index monitor with the Comfort score in assessing level of sedation of critically ill children. Intensive Care Med 29:2239-2246
9. Benini F, Trapanotto M, Sartori S, Capretta A, Gobber D, Boniver C, Zacchello F (2005) Analysis of the bispectral index during natural sleep in children. Anesth Analg 101:641-644
10. Anand KJ, Arnold JH (1994) Opioid tolerance and dependence in infants and children. Crit Care Med 22:334-342
11. Ducharme C, Carnevale FA, Clermont M-S, Shea S (2005) A prospective study of adverse reactions to the weaning of opioids and benzodiazepines among critically ill children. Intensive Crit Care Nursing 21:179-186
12. Bray RJ (1998) Propofol infusion syndrome in children. Paediatr Anaesth 8:491-499
13. Olney JW, Young C, Wozniak DF, Ikonomidou C, Jevtovic-Todorovic V (2004) Anesthesia-induced developmental neuroapoptosis. Does it happen in humans? Anesthesiology 101:273-275
14. Young C, Jevtovic-Todorovic V, Qin YQ, Tenkova T, Wang H, Labruyere J, Olney JW (2005) Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain. Br J Pharmacol 4:4
15. Evans WE, Relling MV (2004) Moving towards individualized medicine with pharmacogenomics. Nature 429:464-468
16. Wilson JT (1999) An update on the therapeutic orphan. Pediatrics 104:585-590